{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:07:04Z","timestamp":1779962824105,"version":"3.53.1"},"reference-count":45,"publisher":"Charles University in Prague, Karolinum Press","issue":"1","license":[{"start":{"date-parts":[[2016,3,20]],"date-time":"2016-03-20T00:00:00Z","timestamp":1458432000000},"content-version":"vor","delay-in-days":79,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,3,20]],"date-time":"2016-03-20T00:00:00Z","timestamp":1458432000000},"content-version":"tdm","delay-in-days":79,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prague Med. Rep."],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>\n                    The link between vitamin D and type 2 diabetes mellitus (T2DM) is intensively studied. This study aims to define the serum concentration of 25-hydroxyvitamin D (25-OH D) and to investigate the relationship between 25-OH D status, glycated hemoglobin (HbA1c) and body composition in postmenopausal women with T2DM and in non-diabetic controls. In this cross-sectional study, 75 women with T2DM and 32 control subjects were selected. Serum 25-OH D, intact parathyroid hormone (PTH), calcium, fasting glucose and HbA1c, were measured. The mean 25-OH D level was 21.4 \u00b1 11.4 ng\/ml (range 4.1\u201350.7 ng\/ml) in diabetic women and 30.3 \u00b1 9.4 ng\/ml (range 10.8\u201354.2 ng\/ml) in control group (p&lt;0.001). The prevalence of hypovitaminosis D (&lt; 30 ng\/ml) was higher in vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    non-supplemented T2DM women (89% vs. 63% controls); the difference diminished in vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    (500\u20131000 IU per day) supplemented subgroups (45% diabetics vs. 42% controls). In T2DM women, 25-OH D levels were not associated to HbA1c, duration of diabetes, fasting glucose and PTH levels, however, 25-OH D levels negatively associated with body mass index (p=0.011), total body fat mass (p=0.005) and total body lean mass (p=0.004). The prevalence of hypovitaminosis D is higher in non-supplemented postmenopausal women with T2DM than in non-diabetic controls (89% vs. 63%). Obesity is a risk factor for vitamin D insufficiency in T2DM postmenopausal women. Further studies evaluating relationships between fat, muscle, bone and vitamin D metabolism in T2DM patients are warranted.\n                  <\/jats:p>","DOI":"10.14712\/23362936.2016.1","type":"journal-article","created":{"date-parts":[[2016,3,20]],"date-time":"2016-03-20T18:03:18Z","timestamp":1458496998000},"page":"5-17","source":"Crossref","is-referenced-by-count":14,"title":["High Prevalence of Hypovitaminosis D in Postmenopausal Women with Type 2 Diabetes Mellitus"],"prefix":"10.14712","volume":"117","author":[{"suffix":"Jr.","given":"Ivan","family":"Ra\u0161ka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ria","family":"Ra\u0161kov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edt","family":"Zik\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"\u0160krha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2016,3,20]]},"reference":[{"key":"23362936.2016.1_1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/ageing\/afp109","volume":"38","author":"Avenell","year":"2009","journal-title":"Age Ageing"},{"key":"23362936.2016.1_2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2147\/DMSO.S60569","volume":"7","author":"Badawi","year":"2014","journal-title":"Diabetes Metab. 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