{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:11:34Z","timestamp":1779963094201,"version":"3.53.1"},"reference-count":20,"publisher":"Charles University in Prague, Karolinum Press","issue":"2-3","license":[{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"vor","delay-in-days":269,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"tdm","delay-in-days":269,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prague Med. Rep."],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Malignant melanoma is a malignancy located predominantly in the skin and the incidence of melanoma increases. We compared the markers of bone metabolism \u2013 osteocalcin (OC), beta-carboxyterminal cross-linked telopeptide of type I collagen (\u03b2-CrossLaps, \u03b2-CTx) and tumour marker \u2013 human epididymis protein 4 (HE4) in the serum with finding during the entry examination and the check-up of whole-body bone scintigraphy of the patient with a malignant melanoma. Serum concentrations of OC, \u03b2-CTx, HE4 were determined in 1 patient (female, age 64 years) with malignant melanoma and correlated with the presence of equivocal bone metastases detected by whole-body bone scintigraphy (the entry examination and check-up after 6 months). Concentrations of bone metabolism markers decreased during six months and we observed progress in bone metastases. The change of the markers levels during the entry examination and the check-up of the whole-body bone scintigraphy with equivocal finding of bone metastases could be a sign of a possible initiating progression of malignant melanoma despite a clinically negative finding that does not prove the progression of the disease.<\/jats:p>","DOI":"10.14712\/23362936.2016.14","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T13:54:21Z","timestamp":1474898061000},"page":"129-134","source":"Crossref","is-referenced-by-count":0,"title":["Bone Metabolism of the Patient with a Malignant Melanoma during the Entry Examination and the Check-up of Whole-body Bone Scintigraphy"],"prefix":"10.14712","volume":"117","author":[{"given":"Jaroslav","family":"Weissensteiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Babu\u0161\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"23362936.2016.14_1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/MED.0b013e3283591492","volume":"19","author":"Biver","year":"2012","journal-title":"Curr. 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