{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:08:49Z","timestamp":1779962929907,"version":"3.53.1"},"reference-count":16,"publisher":"Charles University in Prague, Karolinum Press","issue":"2-3","license":[{"start":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T00:00:00Z","timestamp":1505692800000},"content-version":"vor","delay-in-days":260,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T00:00:00Z","timestamp":1505692800000},"content-version":"tdm","delay-in-days":260,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prague Med. Rep."],"published-print":{"date-parts":[[2017]]},"abstract":"\n Recurrent aphthous stomatitis (RAS) is the most common oral ulcerative inflammatory disease with unknown etiology.\n IL-2<\/jats:italic>\n and\n IFN-\u03b3<\/jats:italic>\n are secreted by Th1 cells and the elevated levels of them have been reported in RAS. Single nucleotide polymorphisms (SNPs) of\n IL-2<\/jats:italic>\n and\n IFN-\u03b3<\/jats:italic>\n genes could alter the cytokine production. The aim of this study was to investigate frequencies of\n IL-2<\/jats:italic>\n and\n IFN-\u03b3<\/jats:italic>\n alleles and genotypes in a group of patients with minor-RAS (MiRAS). PCR-SSP method used to type genomic DNA of 64 Iranian patients with MiRAS for\n IL-2<\/jats:italic>\n gene (G \u2013330 T) and (G +166 T) and\n IFN-\u03b3<\/jats:italic>\n gene at position UTR5644 (A\/T). Frequency of each allele and genotype was compared with control group.\n IL-2<\/jats:italic>\n +166 G allele was significantly lower among patients which was reflected in significantly decreased of GG genotype at this position, while\n IL-2<\/jats:italic>\n +166 T allele was significantly higher among patients,\n IL-2<\/jats:italic>\n GT genotype was also significantly higher in RAS patients. No significant differences were found regarding\n IL-2<\/jats:italic>\n \u2013330 G\/T allele frequencies, while\n IL-2<\/jats:italic>\n GT genotype at this position was significantly higher among patients and\n IL-2<\/jats:italic>\n \u2013330 TT genotype was significantly lower among RAS patients. Although no significant differences were found in\n IFN-\u03b3<\/jats:italic>\n allele frequencies at UTR5644 (A\/T), AT genotype at this position was significantly overrepresented among patients compared with controls. Results of this study suggest that certain SNPs of\n IL-2<\/jats:italic>\n and\n IFN-\u03b3<\/jats:italic>\n genes have association with predisposition of individuals to RAS. More studies in different ethnic groups are needed to confirm results of this study.\n <\/jats:p>","DOI":"10.14712\/23362936.2017.7","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T04:45:38Z","timestamp":1505709938000},"page":"81-86","source":"Crossref","is-referenced-by-count":8,"title":["Interleukin-2, Interferon-gamma Gene Polymorphisms in Recurrent Aphthous Stomatitis"],"prefix":"10.14712","volume":"118","author":[{"given":"Shamsolmoulouk","family":"Najafi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hila","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Mohammadzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza Zare","family":"Bidoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Farhadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2017,9,18]]},"reference":[{"key":"23362936.2017.7_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cden.2004.08.001","volume":"49","author":"Akintoye","year":"2005","journal-title":"Dent. 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Cytokine Netw."},{"key":"23362936.2017.7_4","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/sj.gene.6363882","volume":"3","author":"Bazrafshani","year":"2002","journal-title":"Genes Immun."},{"key":"23362936.2017.7_5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1034\/j.1601-0825.2002.02853.x","volume":"8","author":"Bazrafshani","year":"2002","journal-title":"Oral Dis."},{"key":"23362936.2017.7_6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1034\/j.1601-0825.2003.00965.x","volume":"9","author":"Bazrafshani","year":"2003","journal-title":"Oral Dis."},{"key":"23362936.2017.7_7","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.0904-2512.2004.00089.x","volume":"33","author":"Borra","year":"2004","journal-title":"J. Oral Pathol. Med."},{"key":"23362936.2017.7_8","first-page":"827","volume":"134","author":"Buno","year":"1998","journal-title":"Arch. Dermatol."},{"key":"23362936.2017.7_9","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1600-0714.2012.01134.x","volume":"41","author":"Chavan","year":"2012","journal-title":"J. Oral Pathol. Med."},{"key":"23362936.2017.7_10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.imlet.2005.01.002","volume":"99","author":"Lewkowicz","year":"2005","journal-title":"Immunol. Lett."},{"key":"23362936.2017.7_11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00005-011-0134-1","volume":"59","author":"Lewkowicz","year":"2011","journal-title":"Arch. Immunol. Ther. Exp. (Warsz.)"},{"key":"23362936.2017.7_12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3109\/08820139.2014.880119","volume":"43","author":"Najafi","year":"2014","journal-title":"Immunol. Invest."},{"key":"23362936.2017.7_13","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/iji.12228","volume":"42","author":"Najafi","year":"2015","journal-title":"Int. J. Immunogenet."},{"key":"23362936.2017.7_14","doi-asserted-by":"crossref","first-page":"252","DOI":"10.4103\/0973-029X.86669","volume":"15","author":"Preeti","year":"2011","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"23362936.2017.7_15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","volume":"75","author":"Schroder","year":"2004","journal-title":"J. Lekoc. Biol."},{"key":"23362936.2017.7_16","first-page":"95","volume":"31","author":"Ship","year":"2000","journal-title":"Quintessence Int."}],"container-title":["Prague Medical Report"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pmr.lf1.cuni.cz\/media\/pdf\/pmr_2017118020081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pmr.lf1.cuni.cz\/media\/pdf\/pmr_2017118020081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:37:16Z","timestamp":1779961036000},"score":1,"resource":{"primary":{"URL":"https:\/\/pmr.lf1.cuni.cz\/118\/2\/0081\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":16,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2017]]}},"alternative-id":["pmr_2017118020081"],"URL":"https:\/\/doi.org\/10.14712\/23362936.2017.7","relation":{},"ISSN":["1214-6994","2336-2936"],"issn-type":[{"value":"1214-6994","type":"print"},{"value":"2336-2936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}