{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:05:23Z","timestamp":1779962723483,"version":"3.53.1"},"reference-count":19,"publisher":"Charles University in Prague, Karolinum Press","issue":"3","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":281,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"tdm","delay-in-days":281,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prague Med. Rep."],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>Galectin-3 (gal-3) is lectin which is presumed to interact with extracellular matrix proteins and cell surface glycoproteins in normal and pathophysiological conditions. The expression of gal-3 at the fetal-maternal interface partially overlaps that of gal-1, suggesting that an interplay between them might be important for hypertensive disorders in pregnancy like preeclampsia. The aim of our study was to test the hypothesis whether galectin-3 could be used as a predictive marker for early-onset preeclampsia development. 32 patients with early-onset preeclampsia were examined, mean age 28.8 \u00b1 5.5; and 22 age matched normal pregnancies mean age 28.5 \u00b1 6.0. The enzyme-linked immunosorbent assay (ELISA) was used for measuring serum galectin-3 levels. There were no significant differences between serum levels of galectin-3 in sera of preeclampsia patients compared to normal pregnant women \u2013 14.1 \u00b1 4.77 vs. 15.7 \u00b1 5.95 ng\/ml (p&gt;0.05). Serum galectin-3 levels correlated with maternal age (r=0.33; p=0.03) and BMI (body mass index) (r=0.52; p=0.01). Our data suggest that determination of serum galectin-3 levels may not be a useful method for prediction of early-onset preeclampsia. Studies should be aimed to other categories of biomarkers.<\/jats:p>","DOI":"10.14712\/23362936.2020.16","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T05:28:19Z","timestamp":1602134899000},"page":"172-180","source":"Crossref","is-referenced-by-count":6,"title":["Serum Galectin-3 Levels Are Unlikely to Be a Useful Predictive Marker for Early-onset Preeclampsia Development"],"prefix":"10.14712","volume":"121","author":[{"given":"Asparuh","family":"Nikolov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Popovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Blazhev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"23362936.2020.16_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.imbio.2009.08.001","volume":"215","author":"Alves","year":"2010","journal-title":"Immunobiology"},{"key":"23362936.2020.16_2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jri.2013.05.005","volume":"102","author":"Blois","year":"2014","journal-title":"J. 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