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The urologist suspected a urethral caruncle: the patient was discharged with vaginal oestrogen cream to relieve symptoms and a follow-up was suggested. After two months the patient returned to the Emergency Department since the mass was increasing in volume and complaining of dysuria and haematuria. Ultrasound, contrast-enhanced computed tomography, and contrast-enhanced magnetic resonance revealed a mass arising from the mucosa and involving the vulva and the urethra, suspicious of malignancy. We present a challenging diagnosis of an infiltrative and rapidly progressive primary vulval amelanotic melanoma with a complete imaging evaluation and a confirmed histological diagnosis.<\/jats:p>","DOI":"10.14712\/23362936.2024.23","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T06:20:16Z","timestamp":1724307616000},"page":"256-263","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Primary Vulval Amelanotic Melanoma Involving the Urethra"],"prefix":"10.14712","volume":"125","author":[{"given":"Manuela","family":"Montatore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Eusebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Masino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia Mariagrazia","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willy","family":"Giannubilo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferioli","family":"Elena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucilla","family":"Diamanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Guglielmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"23362936.2024.23_1","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1097\/DAD.0b013e3182a18f8c","volume":"37","author":"Filippetti","year":"2015","journal-title":"Am. 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