{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:58:52Z","timestamp":1791205132616,"version":"4.1.0"},"reference-count":24,"publisher":"Charles University in Prague, Karolinum Press","issue":"3","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":277,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":277,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prague Med. Rep."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Metabolic dysfunction-associated steatohepatitis (MASH) represents a significant global health burden, affecting 3\u20135% of the population and projected to become a leading cause of liver transplantation by 2030. This review examines Resmetirom, the first FDA-approved drug for non-cirrhotic MASH with moderate to severe hepatic fibrosis. As a selective thyroid hormone receptor beta (THR-\u03b2) agonist, Resmetirom enhances hepatic lipid metabolism through increased mitochondrial \u03b2-oxidation and improved lipoprotein profiles. Multiple clinical trials have demonstrated its efficacy in reducing hepatic fat content, improving liver histology, and resolving MASH without worsening fibrosis. While generally well-tolerated, gastrointestinal side effects including diarrhea and nausea were more common with Resmetirom than placebo. This breakthrough therapy offers a promising option for MASH management, though long-term studies and broader geographic representation in trials remain necessary to fully establish its role in clinical practice.<\/jats:p>","DOI":"10.14712\/23362936.2026.21","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:50:31Z","timestamp":1791204631000},"page":"145-150","source":"Crossref","is-referenced-by-count":0,"title":["Resmetirom: A New FDA-approved Drug as a Targeted Therapeutic Strategy in Metabolic Dysfunction Associated Steatohepatitis: Translational Evidence from Current Clinical Trials"],"prefix":"10.14712","volume":"127","author":[{"given":"Ghulam Hassam-u-din","family":"Tarrar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Shafaat","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2735-9852","authenticated-orcid":false,"given":"Muhammad Raza","family":"Sarfraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malka A.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar Kanti","family":"Bhadra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"23362936.2026.21_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1515\/jbcpp-2024-0140","volume":"36","author":"Ayesh","year":"2025","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"23362936.2026.21_2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/hep.29797","volume":"68","author":"Caussy","year":"2018","journal-title":"Hepatology"},{"key":"23362936.2026.21_3","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1053\/j.gastro.2022.07.085","volume":"163","author":"DeBosch","year":"2022","journal-title":"Gastroenterology"},{"key":"23362936.2026.21_4","first-page":"1169","volume":"29","author":"Fahim","year":"2023","journal-title":"J. Manag. Care Spec. Pharm."},{"key":"23362936.2026.21_5","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1530\/EC-20-0490","volume":"10","author":"Gariani","year":"2021","journal-title":"Endocr. Connect."},{"key":"23362936.2026.21_6","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1016\/S0140-6736(19)32517-6","volume":"394","author":"Harrison","year":"2019","journal-title":"Lancet"},{"key":"23362936.2026.21_7","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/hep4.1657","volume":"5","author":"Harrison","year":"2021","journal-title":"Hepatol. Commun."},{"key":"23362936.2026.21_8","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41591-023-02242-6","volume":"29","author":"Harrison","year":"2023","journal-title":"Nat. Med."},{"key":"23362936.2026.21_9","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1038\/s41591-023-02603-1","volume":"29","author":"Harrison","year":"2023","journal-title":"Nat. Med."},{"key":"23362936.2026.21_10","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2309000","volume":"390","author":"Harrison","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"23362936.2026.21_11","doi-asserted-by":"crossref","first-page":"e70025","DOI":"10.1002\/jgh3.70025","volume":"8","author":"Hashim","year":"2024","journal-title":"JGH Open"},{"key":"23362936.2026.21_12","doi-asserted-by":"crossref","first-page":"155835","DOI":"10.1016\/j.metabol.2024.155835","volume":"154","author":"Kokkorakis","year":"2024","journal-title":"Metabolism"},{"key":"23362936.2026.21_13","doi-asserted-by":"crossref","first-page":"100220","DOI":"10.1016\/j.lansea.2023.100220","volume":"15","author":"Niriella","year":"2023","journal-title":"Lancet Reg. Health Southeast Asia"},{"key":"23362936.2026.21_14","first-page":"697","volume":"19","author":"Rinella","year":"2023","journal-title":"Gastroenterol. Hepatol. (N. Y.)"},{"key":"23362936.2026.21_15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S2468-1253(19)30342-5","volume":"5","author":"Sarin","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"23362936.2026.21_16","first-page":"193","volume":"31","author":"Shah","year":"2018","journal-title":"Pak. J. Pharm. Sci."},{"key":"23362936.2026.21_17","doi-asserted-by":"crossref","first-page":"128","DOI":"10.2174\/1389557523666230314113543","volume":"24","author":"Singha","year":"2024","journal-title":"Mini Rev. Med. Chem."},{"key":"23362936.2026.21_18","doi-asserted-by":"crossref","first-page":"19790","DOI":"10.1038\/s41598-024-70242-8","volume":"14","author":"Suvarna","year":"2024","journal-title":"Sci. Rep."},{"key":"23362936.2026.21_19","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S2468-1253(23)00159-0","volume":"8","author":"Tilg","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"23362936.2026.21_20","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/s41401-022-00874-x","volume":"43","author":"Tong","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"23362936.2026.21_21","unstructured":"US Food and Drug Administration (2024) FDA approves first treatment for patients with liver scarring due to fatty liver disease. Available at: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-treatment-patients-liver-scarring-due-fatty-liver-disease"},{"key":"23362936.2026.21_22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41392-022-01119-3","volume":"7","author":"Xu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"23362936.2026.21_23","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1053\/j.gastro.2016.03.005","volume":"150","author":"Younossi","year":"2016","journal-title":"Gastroenterology"},{"key":"23362936.2026.21_24","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.cgh.2021.07.039","volume":"20","author":"Younossi","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."}],"container-title":["Prague Medical Report"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pmr.lf1.cuni.cz\/media\/pdf\/pmr_2026127030145.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:50:35Z","timestamp":1791204635000},"score":1,"resource":{"primary":{"URL":"https:\/\/pmr.lf1.cuni.cz\/127\/3\/0145\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026]]}},"alternative-id":["pmr_2026127030145"],"URL":"https:\/\/doi.org\/10.14712\/23362936.2026.21","relation":{},"ISSN":["1214-6994","2336-2936"],"issn-type":[{"value":"1214-6994","type":"print"},{"value":"2336-2936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}