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Biol."],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>\n                    The SHR and the PD\/Cub are two established rodent models of human metabolic syndrome. Introgression of a ca 30 cM region of rat chromosome 8 from PD\/Cub onto the genetic background of SHR was previously shown to influence several of the metabolic syndrome-related traits along with causing the PLS in the SHR-\n                    <jats:italic>Lx<\/jats:italic>\n                    congenic strain. In the process of identification of the causative alleles, we have produced several congenic sublines. The differential segment of SHR-\n                    <jats:italic>Lx<\/jats:italic>\n                    PD5 congenic substrain [SHR.PD(\n                    <jats:italic>D8Rat42-D8Arb23<\/jats:italic>\n                    )\/Cub] spans approximately 1.4 Mb encompassing only 14 genes. When comparing the metabolic, morphometric and gene expression profiles of the SHR-\n                    <jats:italic>Lx<\/jats:italic>\n                    PD5 vs. SHR, the polydactyly and several distinct metabolic features observed in the original SHR-\n                    <jats:italic>Lx<\/jats:italic>\n                    congenic were still manifested, suggesting that the responsible genes were \u201ctrapped\u201d within the relatively short differential segment of PD\/Cub origin in SHR-\n                    <jats:italic>Lx<\/jats:italic>\n                    PD5. Particularly, the SHR-Lx PD5 displayed substantial reduction of insulin sensitivity confined to skeletal muscle. Among the candidate genes, the promyelocytic leukaemia zinc-finger\n                    <jats:italic>Plzf<\/jats:italic>\n                    (\n                    <jats:italic>Zbtb16<\/jats:italic>\n                    ) transcription repressor is most likely responsible for the\n                    <jats:italic>Lx<\/jats:italic>\n                    mutation resulting in PLS and could also be involved in the alteration of metabolic pathways. The sequence analysis of the\n                    <jats:italic>Plzf<\/jats:italic>\n                    gene revealed a SNP leading to a threonine to serine substitution in SHR at aminoacid position 208 (T208S). In summary, we have isolated a 1.4 Mb genomic region syntenic to human chromosome 11q23, which, apart from causing polydactyly-luxate syndrome (PLS), affects total body weight, adiposity, lipid profile, insulin sensitivity of skeletal muscle and related gene expression as shown in the SHR-\n                    <jats:italic>Lx<\/jats:italic>\n                    PD5 congenic substrain.\n                  <\/jats:p>","DOI":"10.14712\/fb2005051030053","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T11:38:33Z","timestamp":1739878713000},"page":"53-61","source":"Crossref","is-referenced-by-count":10,"title":["A 14-gene Region of Rat Chromosome 8 in SHR-Derived Polydactylous Congenic Substrain Affects Muscle-Specific Insulin Resistance, Dyslipidaemia and Visceral Adiposity"],"prefix":"10.14712","volume":"51","author":[{"given":"O.","family":"\u0160eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Li\u0161ka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"\u0160edov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Kazdov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"K\u0159enov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladim\u00edr","family":"K\u0159en","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"fb2005051030053_1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/76014","volume":"25","author":"Barna","year":"2000","journal-title":"Nat. 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