{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:24:46Z","timestamp":1790900686024,"version":"4.1.0"},"reference-count":29,"publisher":"Charles University in Prague, Karolinum Press","issue":"3","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":6166,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"tdm","delay-in-days":6166,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004755","name":"Veterin\u00e1rn\u00ed a Farmaceutick\u00e1 Univerzita Brno","doi-asserted-by":"publisher","award":["28\/2006\/FaF"],"award-info":[{"award-number":["28\/2006\/FaF"]}],"id":[{"id":"10.13039\/501100004755","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NR 9342-3\/2007"],"award-info":[{"award-number":["NR 9342-3\/2007"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fol. Biol."],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>\n                    Involvement of genetic factors in the aetiology of inflammatory bowel disease (IBD) has been known for a long time. Our aim was to investigate the prevalence of polymorphisms in\n                    <jats:italic>NOD2<\/jats:italic>\n                    ,\n                    <jats:italic>ICAM-1<\/jats:italic>\n                    and\n                    <jats:italic>CCR5<\/jats:italic>\n                    genes in Czech and Slovak patients with IBD in comparison with healthy controls. The frequency of well-known mutations (R702W, G908W and 1007fs in the\n                    <jats:italic>NOD2<\/jats:italic>\n                    gene; K469E in the\n                    <jats:italic>ICAM-1<\/jats:italic>\n                    gene, and \u039432 in the\n                    <jats:italic>CCR5<\/jats:italic>\n                    gene) involved in IBD was tested in 45 patients with CD and 22 patients with UC. The allele frequency of these mutations was determined and genotype-phenotype correlation was specified. Isolated DNA was genotyped, and allele frequency was counted and statistically verified. Significant differences between the healthy control group and CD patients were observed in mutation 1007fs of the\n                    <jats:italic>NOD2<\/jats:italic>\n                    gene (P = 0.0203). We also associated allele E469 of the\n                    <jats:italic>ICAM-1<\/jats:italic>\n                    gene with CD (P = 0.0024). No significant association between other alleles and CD was found, and no gene variation was linked to UC. The number of mutations and mutated genes was higher among patients with CD than among patients with UC. Our results support previous findings about participation of mutations of\n                    <jats:italic>NOD2<\/jats:italic>\n                    and\n                    <jats:italic>ICAM-1<\/jats:italic>\n                    genes in IBD. We confirmed that both CD and UC are polygenic diseases with a gene-dosage effect. This observation strengthens the opinion that genetic factors play a more important role in CD than in UC.\n                  <\/jats:p>","DOI":"10.14712\/fb2008054030088","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T05:58:56Z","timestamp":1731909536000},"page":"88-96","source":"Crossref","is-referenced-by-count":3,"title":["Frequency of Representative Single Nucleotide Polymorphisms Associated with Inflammatory Bowel Disease in the Czech Republic and Slovak Republic"],"prefix":"10.14712","volume":"54","author":[{"given":"J.","family":"Ho\u0161ek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladislava","family":"Barto\u0161ov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gregor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kolorz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"D\u00edt\u011b","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"B\u00e1tovsk\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Barto\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"fb2008054030088_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/01.sla.0000186173.14696.ea","volume":"242","author":"Alvarez-Lobos","year":"2005","journal-title":"Ann. Surg."},{"key":"fb2008054030088_2","doi-asserted-by":"crossref","first-page":"895","DOI":"10.7326\/0003-4819-143-12-200512200-00007","volume":"143","author":"Bamias","year":"2005","journal-title":"Ann. Intern. Med."},{"key":"fb2008054030088_3","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1053\/gast.2003.50045","volume":"124","author":"Bonen","year":"2003","journal-title":"Gastroenterology"},{"key":"fb2008054030088_4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00109-005-0685-x","volume":"83","author":"Braat","year":"2005","journal-title":"J. Mol. Med."},{"key":"fb2008054030088_5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1006\/clim.2001.5118","volume":"101","author":"Braun","year":"2001","journal-title":"Clin. Immunol."},{"key":"fb2008054030088_6","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.3748\/wjg.v12.i23.3668","volume":"23","author":"Halme","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"fb2008054030088_7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0165-2478(01)00199-7","volume":"77","author":"Herfarth","year":"2001","journal-title":"Immunol. Lett."},{"key":"fb2008054030088_8","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/379821a0","volume":"379","author":"Hugot","year":"1996","journal-title":"Nature"},{"key":"fb2008054030088_9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","volume":"411","author":"Hugot","year":"2001","journal-title":"Nature"},{"key":"fb2008054030088_10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1365-2036.2005.02629.x","volume":"22","author":"Laghi","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"key":"fb2008054030088_11","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1086\/339432","volume":"70","author":"Lesage","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"fb2008054030088_12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00054725-200405000-00001","volume":"10","author":"Low","year":"2004","journal-title":"Inflamm. Bowel Dis."},{"key":"fb2008054030088_13","unstructured":"Luk\u00e1\u0161, M. (2003) Granulomatous colitis and ulcerous colitis. In: Medical Repetitorium, ed. Houdek, L., pp. 294-296, Gal\u00e9n, Praha. (in Czech)"},{"key":"fb2008054030088_14","doi-asserted-by":"crossref","first-page":"R161","DOI":"10.1093\/hmg\/ddh079","volume":"13","author":"Mathew","year":"2004","journal-title":"Hum. Mol. 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