{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:05:06Z","timestamp":1779962706600,"version":"3.53.1"},"reference-count":49,"publisher":"Charles University in Prague, Karolinum Press","issue":"5","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":5759,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"tdm","delay-in-days":5759,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fol. Biol."],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>\n                    Mesenchymal stromal cells (MSCs) represent a unique cell type with anti-proliferative effects on activated T and B cells. Based on our observation of differences between rheumatoid arthritis and osteoarthritis bone marrow B cells we hypothesized that rheumatoid arthritis bone marrow MSCs may enhance B-cell survival. We aimed to compare the effect of rheumatoid arthritis and osteoarthritis bone marrow-derived MSCs (rheumatoid arthritis MSCs, osteoarthritis MSCs) on the survival of healthy donor purified B cells. Rheumatoid arthritis and osteoarthritis MSCs were isolated from patients undergoing hip replacement surgery, and cultured in vitro for 2\u20135 passages. Washed cells were co-cultured with CD20\n                    <jats:sup>+<\/jats:sup>\n                    B cells for 30-90 hours. Cell survival was analysed using 7-amino-actinomycin D labelling by flow cytometry. Expression of mRNA and protein was determined by RT-PCR and flow cytomery. Co-culture with both rheumatoid arthritis MSCs and osteoarthritis MSCs significantly enhanced B-cell survival, the effect being more prominent in rheumatoid arthritis MSCs. Both types of MSCs displayed expression of B cell-activating factor mRNA and protein. Blocking B cell-activating factor signalling from MSCs by specific anti-B cell-activating factor and anti-B cell-activating factor receptor antibodies weakly reversed the effect of MSCs on B-cell survival mainly in rheumatoid arthritis MSCs. MSC interaction with B cells provides stimuli for B-cell survival and therefore may contribute to the pathogenesis of rheumatoid arthritis. MSC-derived factors other than B cell-activating factor are likely to contribute to this effect. This feature is more prominent in rheumatoid arthritis MSCs, possibly due to the B cell-activating factor.\n                  <\/jats:p>","DOI":"10.14712\/fb2009055050166","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T12:59:44Z","timestamp":1728392384000},"page":"166-176","source":"Crossref","is-referenced-by-count":7,"title":["BAFF from Bone Marrow-Derived Mesenchymal Stromal Cells of Rheumatoid Arthritis Patients Improves Their B-Cell Viability-Supporting Properties"],"prefix":"10.14712","volume":"55","author":[{"given":"Tom\u00e1\u0161","family":"Dallos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Krivo\u0161\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Chor\u0105zy-Massalska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Warnawin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Z\u00e1\u0148ov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Rudnicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Radzikowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Ma\u015bli\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"fb2009055050166_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum."},{"key":"fb2009055050166_2","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1634\/stemcells.2007-0068","volume":"25","author":"Benvenuto","year":"2007","journal-title":"Stem Cells"},{"key":"fb2009055050166_3","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1002\/art.20356","volume":"50","author":"Braun","year":"2004","journal-title":"Arthritis Rheum."},{"key":"fb2009055050166_4","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/1529-0131(200106)44:6<1313::AID-ART223>3.0.CO;2-S","volume":"44","author":"Cheema","year":"2001","journal-title":"Arthritis Rheum."},{"key":"fb2009055050166_5","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1532\/IJH97.A30409","volume":"80","author":"Chung","year":"2004","journal-title":"Int. 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