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Biol."],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Microcystins are cyclic peptide toxins. Chronic intoxication with well-known members of the microcystin family \u2013 microcystins-LR \u2013 induces liver tumour formation, injury of kidney and heart. Despite worldwide distribution in the environment, the effects of microcystins-YR have not been studied extensively. The aim of the study was to evaluate whether microcystins-YR, in relatively low doses, have a toxic effect on cardiomyocytes of chronically treated rats. Male adult Wistar rats were treated every second day for 8 months with microcystins-YR (10 \u00b5g\/kg i.p., N = 5). Control groups were treated either with vehicle (ethanol and methanol 4 : 1 v\/v; N = 5) or with physiologic saline (N = 4). The heart sections of microcystin-YR-treated rats revealed decreased volume density of cardiac muscle tissue (microcystins-YR = 0.485 mm3\/mm3 \u00b1 0.003; vehicle = 0.493 mm3\/mm3 \u00b1 0.002; saline = 0.492 mm3\/mm3 \u00b1 0.002) due to fibrous proliferation. A few lymphocyte infiltrates were observed. Most of cardiomyocytes were enlarged (microcystins-YR = 20.19 \u03bcm \u00b1 1.34, vehicle = 17.45 \u03bcm \u00b1 0.52, saline = 16.00 \u03bcm \u00b1 1.43), with enlarged and often bizarre-shaped nuclei and decreased myofibril volume fraction (microcystinsYR = 0.416 mm3\/mm3 \u00b1 0.009; vehicle = 0.472 mm3\/mm3 \u00b1 0.009; saline = 0.479 mm3\/mm3 \u00b1 0.010). No TUNEL-positive cells were found in the heart sections of rats in all groups. The results allow the conclusion that chronic exposure to low doses of microcystins-YR may cause atrophy and fibrosis of the heart muscle.<\/jats:p>","DOI":"10.14712\/fb2010056010014","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T04:02:03Z","timestamp":1727496123000},"page":"14-18","source":"Crossref","is-referenced-by-count":13,"title":["Cardiotoxic Injury Caused by Chronic Administration of Microcystin-YR"],"prefix":"10.14712","volume":"56","author":[{"given":"D.","family":"\u0160uput","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Zorc-Pleskovi\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Petrovi\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Milutinovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2024,9,28]]},"reference":[{"key":"fb2010056010014_1","doi-asserted-by":"crossref","unstructured":"Carmichael, W. 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