{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:08:55Z","timestamp":1779962935426,"version":"3.53.1"},"reference-count":152,"publisher":"Charles University in Prague, Karolinum Press","issue":"6","license":[{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"vor","delay-in-days":5371,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"tdm","delay-in-days":5371,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fol. Biol."],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>\n                    For over 30 years empirical studies have repeatedly demonstrated that the biosynthesis of morphine by diverse animal and human tissues occurs. Recently, the blue mussel\u2019s neural tissues and human white blood cells were used to demonstrate the\n                    <jats:italic>de novo<\/jats:italic>\n                    biosynthesis of morphine for small precursor molecules derived from the aromatic amino acid L-tyrosine. Because catecholamine precursors, i.e., L-3,4-dihydroxyphenylalanine (L-DOPA), were also found to be utilized as morphine precursors, a novel reciprocally interactive mechanism is apparent that links catecholamine and opioid pathways in the activation and inhibition of diverse tissue responses. Additionally, these observations provide new insights into morphinergic signalling that transcend analgesia and addiction. We have also linked the biological effects of nitric oxide into a common effect in endogenous morphine signalling. Given the singular importance of dopamine and morphine\u2019s interaction in the CNS, the presence and association of this signalling with nitric oxide all promises to provide novel answers for mental health phenomena, which have been lacking because of the inability in accepting the empirical endogenous morphine studies.\n                  <\/jats:p>","DOI":"10.14712\/fb2010056060231","type":"journal-article","created":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T16:19:43Z","timestamp":1726417183000},"page":"231-241","source":"Crossref","is-referenced-by-count":9,"title":["Psychiatric Implications of Endogenous Morphine: Up-To-Date Review"],"prefix":"10.14712","volume":"56","author":[{"given":"R. M.","family":"Kream","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George B.","family":"Stefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Pt\u00e1\u010dek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2024,9,15]]},"reference":[{"key":"fb2010056060231_1","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/S0024-3205(00)00782-7","volume":"67","author":"Abreu","year":"2000","journal-title":"Life Sci."},{"key":"fb2010056060231_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0006-8993(98)00983-4","volume":"812","author":"Arai","year":"1998","journal-title":"Brain Res."},{"key":"fb2010056060231_3","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s007020050192","volume":"106","author":"Berg","year":"1999","journal-title":"J. Neural Transm."},{"key":"fb2010056060231_4","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s007020170022","volume":"108","author":"Berg","year":"2001","journal-title":"J. Neural Transm."},{"key":"fb2010056060231_5","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/0006-8993(93)90323-F","volume":"627","author":"Bianchi","year":"1993","journal-title":"Brain Res."},{"key":"fb2010056060231_6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0960-5428(05)80003-8","volume":"4","author":"Bianchi","year":"1994","journal-title":"Adv. Neuroimmunol."},{"key":"fb2010056060231_7","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0003-4975(97)00167-7","volume":"63","author":"Bilfinger","year":"1997","journal-title":"Ann. Thorac. Surg."},{"key":"fb2010056060231_8","doi-asserted-by":"crossref","first-page":"8495","DOI":"10.1073\/pnas.0503244102","volume":"102","author":"Boettcher","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"fb2010056060231_9","first-page":"321","volume":"90","author":"Britton","year":"1982","journal-title":"Prog. Clin. Biol. Res."},{"key":"fb2010056060231_10","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1034\/j.1399-6576.2000.441004.x","volume":"44","author":"Brix-Christensen","year":"2000","journal-title":"Acta Anaesthesiol. Scand."},{"key":"fb2010056060231_11","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.4049\/jimmunol.170.10.5118","volume":"170","author":"Cadet","year":"2003","journal-title":"J. Immunol."},{"key":"fb2010056060231_12","first-page":"485","volume":"12","author":"Cadet","year":"2003","journal-title":"Int. J. Mol. Med."},{"key":"fb2010056060231_13","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.2741\/1471","volume":"9","author":"Cadet","year":"2004","journal-title":"Front. Biosci."},{"key":"fb2010056060231_14","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.4049\/jimmunol.179.9.5839","volume":"179","author":"Cadet","year":"2007","journal-title":"J. Immunol."},{"key":"fb2010056060231_15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0024-3205(87)90347-X","volume":"40","author":"Cardinale","year":"1987","journal-title":"Life Sci."},{"key":"fb2010056060231_16","first-page":"89","volume":"26","author":"Casares","year":"2005","journal-title":"Neuro Endocrinol. Lett."},{"key":"fb2010056060231_17","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0028-3908(83)90181-8","volume":"22","author":"Clow","year":"1983","journal-title":"Neuropharmacol."},{"key":"fb2010056060231_18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00004714-198107000-00007","volume":"1","author":"Cohen","year":"1981","journal-title":"J. Clin. Psychopharmacol."},{"key":"fb2010056060231_19","first-page":"53","volume":"5","author":"Collins","year":"1979","journal-title":"Curr. Alcohol."},{"key":"fb2010056060231_20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0161-813X(03)00145-1","volume":"25","author":"Collins","year":"2004","journal-title":"Neurotoxicology"},{"key":"fb2010056060231_21","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/S0140-6736(77)90623-7","volume":"2","author":"Comfort","year":"1977","journal-title":"Lancet"},{"key":"fb2010056060231_22","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/269617a0","volume":"269","author":"Coscia","year":"1977","journal-title":"Nature"},{"key":"fb2010056060231_23","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1126\/science.167.3920.1005","volume":"167","author":"Davis","year":"1970","journal-title":"Science"},{"key":"fb2010056060231_24","first-page":"401","volume":"174","author":"Davis","year":"1970","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"fb2010056060231_25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-4757-0632-1_6","volume":"59","author":"Davis","year":"1975","journal-title":"Adv. Exp. Med. Biol."},{"key":"fb2010056060231_26","unstructured":"DiChiara, G., Acquas, E., Carboni, E. (1990) Dopamine and drug-induced motivation. In: Dopamine and Mental Depression, eds. Gessa G. L., Serra G, pp. 27-38, Pergamon Press, Oxford."},{"key":"fb2010056060231_27","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1073\/pnas.83.12.4566","volume":"83","author":"Donnerer","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"fb2010056060231_28","first-page":"583","volume":"242","author":"Donnerer","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"fb2010056060231_29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0741-8329(91)91314-R","volume":"8","author":"Duncan","year":"1991","journal-title":"Alcohol"},{"key":"fb2010056060231_30","first-page":"CR1-10","volume":"12","author":"Dusek","year":"2006","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_31","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1345\/aph.1G499","volume":"40","author":"Elchaar","year":"2006","journal-title":"Ann. Pharmacother."},{"key":"fb2010056060231_32","doi-asserted-by":"crossref","first-page":"PL117","DOI":"10.1016\/0024-3205(93)90175-3","volume":"52","author":"Epple","year":"1993","journal-title":"Life Sci."},{"key":"fb2010056060231_33","first-page":"175","volume":"26","author":"Esch","year":"2005","journal-title":"Neuro Endocrinol. Lett."},{"key":"fb2010056060231_34","first-page":"21","volume":"27","author":"Esch","year":"2006","journal-title":"Neuro Endocrinol. Lett."},{"key":"fb2010056060231_35","first-page":"29","volume":"17","author":"Extein","year":"1981","journal-title":"Psychopharmacol. Bull."},{"key":"fb2010056060231_36","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0960-5428(05)80006-3","volume":"4","author":"Fricchione","year":"1994","journal-title":"Adv. Neuroimmunol."},{"key":"fb2010056060231_37","first-page":"MS54","volume":"11","author":"Fricchione","year":"2005","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_38","first-page":"CS45","volume":"14","author":"Fricchione","year":"2008","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_39","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1016\/0006-2952(82)90558-5","volume":"31","author":"Galloway","year":"1982","journal-title":"Biochem. Pharmacol."},{"key":"fb2010056060231_40","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1073\/pnas.73.6.2132","volume":"73","author":"Gintzler","year":"1976","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"fb2010056060231_41","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1126\/science.339350","volume":"199","author":"Gintzler","year":"1978","journal-title":"Science"},{"key":"fb2010056060231_42","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1749-6632.1982.tb39488.x","volume":"398","author":"Gold","year":"1982","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"fb2010056060231_43","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1073\/pnas.82.15.5203","volume":"82","author":"Goldstein","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"fb2010056060231_44","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0304-3940(98)00663-6","volume":"254","author":"Gonzalez","year":"1998","journal-title":"Neurosci. Lett."},{"key":"fb2010056060231_45","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0169-328X(00)00056-5","volume":"77","author":"Goumon","year":"2000","journal-title":"Mol. Brain. Res."},{"key":"fb2010056060231_46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0304-3940(00)01507-X","volume":"293","author":"Goumon","year":"2000","journal-title":"Neurosci. Lett."},{"key":"fb2010056060231_47","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4049\/jimmunol.165.1.339","volume":"165","author":"Goumon","year":"2000","journal-title":"J. Immunol."},{"key":"fb2010056060231_48","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0169-328X(00)00141-8","volume":"81","author":"Goumon","year":"2000","journal-title":"Mol. Brain. Res."},{"key":"fb2010056060231_49","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0169-328X(00)00132-7","volume":"86","author":"Goumon","year":"2001","journal-title":"Mol. Brain. Res."},{"key":"fb2010056060231_50","first-page":"MS31","volume":"11","author":"Goumon","year":"2005","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_51","first-page":"119","volume":"184","author":"Greenberg","year":"1973","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"fb2010056060231_52","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1471-4159.1998.70010147.x","volume":"70","author":"Guarna","year":"1998","journal-title":"J. Neurochem."},{"key":"fb2010056060231_53","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.0022-3042.2001.00708.x","volume":"80","author":"Guarna","year":"2002","journal-title":"J. Neurochem."},{"key":"fb2010056060231_54","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1017\/S1461145704004341","volume":"7","author":"Guarna","year":"2004","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"fb2010056060231_55","first-page":"RA190","volume":"11","author":"Guarna","year":"2005","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_56","doi-asserted-by":"crossref","first-page":"33711","DOI":"10.1074\/jbc.M205146200","volume":"277","author":"Guengerich","year":"2002","journal-title":"J. Biol. Chem."},{"key":"fb2010056060231_57","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1126\/science.169.3950.1104","volume":"169","author":"Halushka","year":"1970","journal-title":"Science"},{"key":"fb2010056060231_58","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1124\/mol.61.1.194","volume":"61","author":"Hara","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"fb2010056060231_59","first-page":"250","volume":"179","author":"Heikkila","year":"1971","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"fb2010056060231_60","first-page":"172","volume":"12","author":"Herman","year":"1986","journal-title":"Soc. Neurosci."},{"key":"fb2010056060231_61","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1006\/bbrc.1998.9232","volume":"249","author":"Hiroi","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"fb2010056060231_62","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-4347(99)00090-0","volume":"727","author":"Hofmann","year":"1999","journal-title":"J. Chromatogr. B. Biomed. Sci. Appl."},{"key":"fb2010056060231_63","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/S0140-6736(71)91629-1","volume":"1","author":"Johnston","year":"1971","journal-title":"Lancet"},{"key":"fb2010056060231_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-3223(92)90137-O","volume":"32","author":"Kapur","year":"1992","journal-title":"Biol. Psych."},{"key":"fb2010056060231_65","first-page":"217","volume":"13","author":"Katz","year":"1976","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"fb2010056060231_66","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0024-3205(81)90165-X","volume":"28","author":"Killian","year":"1981","journal-title":"Life Sci."},{"key":"fb2010056060231_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2005.04.105","volume":"386","author":"Kim","year":"2005","journal-title":"Neurosci. Lett."},{"key":"fb2010056060231_68","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1073\/pnas.85.4.1267","volume":"85","author":"Kodaira","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"fb2010056060231_69","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1073\/pnas.86.2.716","volume":"86","author":"Kodaira","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"fb2010056060231_70","doi-asserted-by":"crossref","first-page":"9218","DOI":"10.1016\/S0021-9258(19)70549-3","volume":"255","author":"Kream","year":"1980","journal-title":"J. Biol. Chem."},{"key":"fb2010056060231_71","first-page":"RA207","volume":"12","author":"Kream","year":"2006","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_72","first-page":"SC5","volume":"13","author":"Kream","year":"2007","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_73","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1600-0447.1978.tb06883.x","volume":"57","author":"Lindstrom","year":"1978","journal-title":"Acta Psychiatr. Scand."},{"key":"fb2010056060231_74","doi-asserted-by":"crossref","unstructured":"Lipska, B. K., Weinberger, D. R. (1993) Cortical regulation of the mesolimbic dopamine system: Implications for schizophrenia. In: Limbic Motor Circuits and Neuropsychiatry, eds. Kalivas P. W., Barnes C. D. pp 329-349, CRC Press, Boca Raton, FL.","DOI":"10.1201\/9780429274411-11"},{"key":"fb2010056060231_75","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0006-8993(96)00204-1","volume":"722","author":"Liu","year":"1996","journal-title":"Brain Res."},{"key":"fb2010056060231_76","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1369-1600.2007.00072.x","volume":"13","author":"Mantione","year":"2008","journal-title":"Addict. Biol."},{"key":"fb2010056060231_77","first-page":"974","volume":"260","author":"Matsubara","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"fb2010056060231_78","doi-asserted-by":"crossref","first-page":"14215","DOI":"10.1021\/bi0110037","volume":"40","author":"Miller","year":"2001","journal-title":"Biochemistry"},{"key":"fb2010056060231_79","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1126\/science.1095943","volume":"304","author":"Moles","year":"2004","journal-title":"Science"},{"key":"fb2010056060231_80","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0024-3205(95)00285-E","volume":"57","author":"Munjal","year":"1996","journal-title":"Life Sci."},{"key":"fb2010056060231_81","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0741-8329(90)90031-7","volume":"7","author":"Myers","year":"1990","journal-title":"Alcohol"},{"key":"fb2010056060231_82","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0741-8329(99)00008-7","volume":"18","author":"Myers","year":"1999","journal-title":"Alcohol"},{"key":"fb2010056060231_83","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-3-7091-6499-0_14","volume":"52","author":"Naoi","year":"1998","journal-title":"J. Neural Transm. Suppl."},{"key":"fb2010056060231_84","first-page":"MS1","volume":"10","author":"Neri","year":"2004","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_85","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1111\/j.1471-4159.2008.05572.x","volume":"106","author":"Neri","year":"2008","journal-title":"J. Neurochem."},{"key":"fb2010056060231_86","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/sj.npp.1300658","volume":"30","author":"Nikulina","year":"2005","journal-title":"Neuropsychopharmacol."},{"key":"fb2010056060231_87","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/jnr.490100207","volume":"10","author":"Nimit","year":"1983","journal-title":"J. Neurosci. Res."},{"key":"fb2010056060231_88","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0378-4347(92)80231-E","volume":"578","author":"Niwa","year":"1992","journal-title":"J. Chromatogr."},{"key":"fb2010056060231_89","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.molbrainres.2004.06.030","volume":"129","author":"Niwa","year":"2004","journal-title":"Brain. Res. Mol. Brain. Res."},{"key":"fb2010056060231_90","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0168-0102(97)00121-1","volume":"30","author":"Okada","year":"1998","journal-title":"Neurosci. Res."},{"key":"fb2010056060231_91","doi-asserted-by":"crossref","unstructured":"Pasternak, G. W. (1988) The Opiate Receptors. Humana Press, Clifton, NJ.","DOI":"10.1007\/978-1-60761-990-1"},{"key":"fb2010056060231_92","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1001\/archpsyc.1982.04290030047009","volume":"39","author":"Pickar","year":"1982","journal-title":"Arch. Gen. Psychiatry"},{"key":"fb2010056060231_93","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1517\/14712598.5.7.893","volume":"5","author":"Pryor","year":"2005","journal-title":"Expert Opin. Biol. Ther."},{"key":"fb2010056060231_94","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/0166-2236(93)90194-Q","volume":"16","author":"Reisine","year":"1993","journal-title":"Trends Neurosci."},{"key":"fb2010056060231_95","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0028-3908(95)00025-2","volume":"34","author":"Reisine","year":"1995","journal-title":"Neuropharmacol."},{"key":"fb2010056060231_96","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0165-1781(84)90008-8","volume":"11","author":"Robertson","year":"1984","journal-title":"Psychiatry Res."},{"key":"fb2010056060231_97","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0741-8329(98)00080-9","volume":"18","author":"Sallstrom","year":"1999","journal-title":"Alcohol"},{"key":"fb2010056060231_98","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/241439a0","volume":"241","author":"Sandler","year":"1973","journal-title":"Nature"},{"key":"fb2010056060231_99","first-page":"215","volume":"90","author":"Sandler","year":"1982","journal-title":"Prog. Clin. Biol. Res."},{"key":"fb2010056060231_100","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/0006-3223(85)90179-9","volume":"20","author":"Schmauss","year":"1985","journal-title":"Biol. Psychiatry"},{"key":"fb2010056060231_101","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.freeradbiomed.2004.02.011","volume":"36","author":"Shin","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"fb2010056060231_102","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mrrev.2003.06.023","volume":"544","author":"Soh","year":"2003","journal-title":"Mutat. Res."},{"key":"fb2010056060231_103","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0006-8993(01)02837-2","volume":"915","author":"Spector","year":"2001","journal-title":"Brain Res."},{"key":"fb2010056060231_104","doi-asserted-by":"crossref","first-page":"11099","DOI":"10.1073\/pnas.90.23.11099","volume":"90","author":"Stefano","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"fb2010056060231_105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0960-5428(05)80001-4","volume":"4","author":"Stefano","year":"1994","journal-title":"Adv. Neuroimmunol."},{"key":"fb2010056060231_106","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0301-0082(94)90048-5","volume":"42","author":"Stefano","year":"1994","journal-title":"Prog. Neurobiol."},{"key":"fb2010056060231_107","doi-asserted-by":"crossref","first-page":"30290","DOI":"10.1074\/jbc.270.51.30290","volume":"270","author":"Stefano","year":"1995","journal-title":"J. Biol. Chem."},{"key":"fb2010056060231_108","first-page":"51","volume":"49","author":"Stefano","year":"1995","journal-title":"Med. Hypotheses"},{"key":"fb2010056060231_109","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0306-9877(95)90255-4","volume":"44","author":"Stefano","year":"1995","journal-title":"Med. Hypotheses"},{"key":"fb2010056060231_110","first-page":"369","volume":"113C","author":"Stefano","year":"1996","journal-title":"Comp. Biochem. Physiol."},{"key":"fb2010056060231_111","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0960-5428(96)00022-8","volume":"6","author":"Stefano","year":"1996","journal-title":"Adv. Neuroimmunol."},{"key":"fb2010056060231_112","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1615\/CritRevImmunol.v16.i2.10","volume":"16","author":"Stefano","year":"1996","journal-title":"Crit. Rev. Immunol."},{"key":"fb2010056060231_113","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0301-0082(99)00038-6","volume":"60","author":"Stefano","year":"2000","journal-title":"Progr. Neurobiol."},{"key":"fb2010056060231_114","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0166-2236(00)01611-8","volume":"9","author":"Stefano","year":"2000","journal-title":"Trends. Neurosci."},{"key":"fb2010056060231_115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0173(00)00047-3","volume":"35","author":"Stefano","year":"2001","journal-title":"Brain Res. Brain Res. Rev."},{"key":"fb2010056060231_116","first-page":"21","volume":"23","author":"Stefano","year":"2002","journal-title":"Neuro Endocrinol. Lett."},{"key":"fb2010056060231_117","unstructured":"Stefano, G. B., Cadet, P., Rialas, C. M., Mantione, K., Casares, F., Goumon, Y., Zhu, W. (2003) Invertebrate opiate immune and neural signaling. In: Immune Mechanisms of Pain and Analgesia, eds. Machelska H., Stein C., pp. 126-147. Plenum Publ., New York, NY."},{"key":"fb2010056060231_118","first-page":"279","volume":"55","author":"Stefano","year":"2004","journal-title":"J. Physiol. Pharmacol."},{"key":"fb2010056060231_119","first-page":"MS18","volume":"10","author":"Stefano","year":"2004","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_120","first-page":"MS47","volume":"11","author":"Stefano","year":"2005","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_121","first-page":"HY21","volume":"12","author":"Stefano","year":"2006","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_122","first-page":"837","volume":"20","author":"Stefano","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"fb2010056060231_123","first-page":"RA91","volume":"13","author":"Stefano","year":"2007","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_124","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.semcancer.2007.12.001","volume":"18","author":"Stefano","year":"2008","journal-title":"Semin. Cancer. Biol."},{"key":"fb2010056060231_125","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/BF00973651","volume":"15","author":"Suzuki","year":"1990","journal-title":"Neurochem. Res."},{"key":"fb2010056060231_126","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1016\/0024-3205(74)90106-4","volume":"14","author":"Turner","year":"1974","journal-title":"Life Sci."},{"key":"fb2010056060231_127","first-page":"388","volume":"174","author":"Walsh","year":"1970","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"fb2010056060231_128","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1176\/ajp.149.7.890","volume":"149","author":"Weinberger","year":"1992","journal-title":"Am. J. Psychiatry"},{"key":"fb2010056060231_129","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1530-0277.1978.tb04712.x","volume":"2","author":"Weiner","year":"1978","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"fb2010056060231_130","first-page":"2082","volume":"40","author":"Weiner","year":"1981","journal-title":"Fed. Proc."},{"key":"fb2010056060231_131","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/330674a0","volume":"330","author":"Weitz","year":"1987","journal-title":"Nature"},{"key":"fb2010056060231_132","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/2271143a0","volume":"227","author":"Yamanaka","year":"1970","journal-title":"Nature"},{"key":"fb2010056060231_133","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0169-328X(01)00048-1","volume":"88","author":"Zhu","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"key":"fb2010056060231_134","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1255\/ejms.384","volume":"7","author":"Zhu","year":"2001","journal-title":"Eur. J. Mass Spectrom."},{"key":"fb2010056060231_135","first-page":"419","volume":"7","author":"Zhu","year":"2001","journal-title":"Int. J. Mol. Med."},{"key":"fb2010056060231_136","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1179\/000349802125000808","volume":"96","author":"Zhu","year":"2002","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"fb2010056060231_137","first-page":"329","volume":"23","author":"Zhu","year":"2002","journal-title":"Neuro Endocrinol. Lett."},{"key":"fb2010056060231_138","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0169-328X(03)00323-1","volume":"117","author":"Zhu","year":"2003","journal-title":"Mol. Brain. Res."},{"key":"fb2010056060231_139","first-page":"323","volume":"25","author":"Zhu","year":"2004","journal-title":"Neuro Endocrinol. Lett."},{"key":"fb2010056060231_140","first-page":"BR433","volume":"10","author":"Zhu","year":"2004","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_141","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1645\/GE-3208","volume":"90","author":"Zhu","year":"2004","journal-title":"J. Parasitol."},{"key":"fb2010056060231_142","doi-asserted-by":"crossref","first-page":"7357","DOI":"10.4049\/jimmunol.175.11.7357","volume":"175","author":"Zhu","year":"2005","journal-title":"J. Immunol."},{"key":"fb2010056060231_143","first-page":"BR397","volume":"11","author":"Zhu","year":"2005","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_144","first-page":"MS1","volume":"11","author":"Zhu","year":"2005","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_145","doi-asserted-by":"crossref","first-page":"5704","DOI":"10.4049\/jimmunol.176.10.5704","volume":"176","author":"Zhu","year":"2006","journal-title":"J. Immunol."},{"key":"fb2010056060231_146","first-page":"BR350","volume":"12","author":"Zhu","year":"2006","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_147","first-page":"BR155","volume":"12","author":"Zhu","year":"2006","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_148","first-page":"BR295","volume":"12","author":"Zhu","year":"2006","journal-title":"Med. Sci. Monit."},{"key":"fb2010056060231_149","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s10571-006-9021-4","volume":"26","author":"Zhu","year":"2006","journal-title":"Cell Mol. Neurobiol."},{"key":"fb2010056060231_150","first-page":"63","volume":"29","author":"Zhu","year":"2008","journal-title":"Neuro Endocrinol. Lett."},{"key":"fb2010056060231_151","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0278-5846(83)90026-X","volume":"7","author":"Zis","year":"1983","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"fb2010056060231_152","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1365-2265.1989.tb00441.x","volume":"30","author":"Zis","year":"1989","journal-title":"Clin. Endocrinol. (Oxf)"}],"container-title":["Folia Biologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/foliabiologica.lf1.cuni.cz\/media\/pdf\/fb_2010056060231.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliabiologica.lf1.cuni.cz\/media\/pdf\/fb_2010056060231.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:37:39Z","timestamp":1779961059000},"score":1,"resource":{"primary":{"URL":"https:\/\/foliabiologica.lf1.cuni.cz\/56\/6\/0231\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":152,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010]]}},"alternative-id":["fb_2010056060231"],"URL":"https:\/\/doi.org\/10.14712\/fb2010056060231","relation":{},"ISSN":["0015-5500","2533-7602"],"issn-type":[{"value":"0015-5500","type":"print"},{"value":"2533-7602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}