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Biol."],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>The intent of the study was to evaluate immune system changes during 12 weeks of abstinence in heroin users. We recruited men (N = 65) aged 18\u201345 years and collected demographic and heroin use pattern data. Serum blood levels of total interleukin 2 (IL-2), interferon \u03b3 (IFN-\u03b3), immunoglobulin (Ig) A, IgG, and IgM were assessed at five time points. The IL-2 level was increased on day 84 as compared to that in healthy controls. The IFN-\u03b3 level was higher in heroin users than in healthy controls between days 0 and 28, and was decreased on day 84. IgG and IgM levels in heroin users were higher than those in healthy controls in our 12-week study, and were in positive correlation with the way of using the drug, duration of heroin dependence, and daily heroin intake. 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