{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:10:44Z","timestamp":1790539844660,"version":"4.1.0"},"reference-count":30,"publisher":"Charles University in Prague, Karolinum Press","issue":"2","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":1806,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"tdm","delay-in-days":1806,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fol. Biol."],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide. Current studies have shown that the Th17\/Treg immune balance may be involved in the occurrence of IgAN, but the exact mechanism is still unclear. Indoleamine 2,3-dioxygenase (IDO) is an enzyme that catalyses degradation of tryptophan (Trp) through the kynurenine (Kyn) pathway; it can control inflammation and immune response by inducing Trp starvation. IDO may be a key molecule in regulating the Th17\/Treg immune balance. However, it is not clear whether IDO is involved in the IgAN disease occurrence by regulating the Th17\/Treg immune balance. In this study, an IgAN mouse model was established. The mice were intraperitoneally inoculated with IDO inhibitor 1-MT or agonist ISS-ODN to observe whether the IDO signalling pathway participates in the occurrence and development of IgAN by regulating the Th17\/Treg immune balance. The results showed that IDO inhibitor 1-MT significantly increased renal injury and glomerular IgA accumulation and up-regulated Th17\/Treg and Th17-related cytokine expression in IgAN mice, while ISS-ODN significantly decreased renal injury and glomerular IgA accumulation, down-regulated Th17\/Treg expression and inhibited Th17-related cytokine expression in IgAN mice. In conclusion, IDO was involved in the occurrence and progress of IgAN by regulating the Th17\/ Treg balance.<\/jats:p>","DOI":"10.14712\/fb2019065020101","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T14:37:32Z","timestamp":1702391852000},"page":"101-108","source":"Crossref","is-referenced-by-count":21,"title":["Indoleamine 2,3-Dioxygenase (IDO) Regulates Th17\/Treg Immunity in Experimental IgA Nephropathy"],"prefix":"10.14712","volume":"65","author":[{"given":"Y.","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"fb2019065020101_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.12688\/wellcomeopenres.14644.1","volume":"3","author":"Alexander","year":"2018","journal-title":"Wellcome Open Res."},{"key":"fb2019065020101_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/clin.1997.4357","volume":"84","author":"Amore","year":"1997","journal-title":"Clin. 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