{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:05:44Z","timestamp":1787022344479,"version":"build-2736575974"},"update-to":[{"DOI":"10.14712\/fb2026.0012","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000}},{"DOI":"10.14712\/fb2026.0012","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000}}],"reference-count":34,"publisher":"Charles University in Prague, Karolinum Press","issue":"3","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":152,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":152,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["foliabiologica.lf1.cuni.cz"],"crossmark-restriction":true},"short-container-title":["Fol. Biol."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Post-stroke cognitive impairment (PSCI) is a common sequela that occurs after ischaemic stroke (IS). This study aimed to investigate whether miR-409-3p is related to PSCI. Patients with IS were divided into two subgroups: PSCI and post-stroke cognitive normality (PSCN). The plasma level of miR-409-3p was determined by RT-qPCR. The association between PSCI and miR-409-3p was evaluated through binary logistic regression and by analysing the correlation between miR-409-3p and the MoCA score. In mice with middle cerebral artery occlusion (MCAO), the effects of miR-409-3p on cognitive function were explored through mNSS score and Morris water maze. In OGD\/R-induced SH-SY5Y cells, the effects of miR-409-3p on cell viability, apoptosis and neuronal inflammation were evaluated using CCK-8, flow cytometry and ELISA. The content of miR-409-3p in patients with IS and those with PSCI was both increased, and its content showed a significant negative correlation with the MoCA score. The binary logistic regression analysis showed that a high risk of PSCI was associated with miR-409-3p. In MCAO mice, inhibition of miR-409-3p can significantly reduce the mNSS score and shorten the escape latency in the Morris water maze. Further\u00admore, in neurons induced by OGD\/R, down-regulation of miR-409-3p can exert a significant protective effect on neurons, manifested by enhanced cell viability, reduced apoptosis rate and inhibition of the synthesis of inflammatory factors. We conclude that miR-409-3p is a risk factor associated with PSCI. In MCAO mice and neurons induced by OGD\/R, inhibition of miR-409-3p significantly alleviated neurological deficits and suppres\u00adsed neuronal apoptosis and neuronal inflammation.<\/jats:p>","DOI":"10.14712\/fb2026.0012","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:27:17Z","timestamp":1780388837000},"page":"118-127","update-policy":"https:\/\/doi.org\/10.14712\/crossmark-policy-fb","source":"Crossref","is-referenced-by-count":1,"title":["Mechanism Study and Analysis of Correlation between miR-409-3p and Post-Stroke Cognitive Impairment"],"prefix":"10.14712","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4661-5831","authenticated-orcid":false,"given":"Shuzhen","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8110-8421","authenticated-orcid":false,"given":"Ning","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengquan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6669-9292","authenticated-orcid":false,"given":"Xiulan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1593-1573","authenticated-orcid":false,"given":"Chunfang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"fb2026.0012_1","doi-asserted-by":"crossref","first-page":"116899","DOI":"10.1016\/j.biopha.2024.116899","volume":"177","author":"Alkhazaali-Ali","year":"2024","journal-title":"Biomed. 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