{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:08:53Z","timestamp":1781885333326,"version":"3.54.5"},"update-to":[{"DOI":"10.14712\/fb2026.0014","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000}},{"DOI":"10.14712\/fb2026.0014","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000}}],"reference-count":34,"publisher":"Charles University in Prague, Karolinum Press","issue":"3","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":155,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"tdm","delay-in-days":155,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["foliabiologica.lf1.cuni.cz"],"crossmark-restriction":true},"short-container-title":["Fol. Biol."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune condition that causes patients pain and seriously affects their quality of life. Therefore, finding a diagnostic marker is of great significance for the prediction and early diagnosis of RA. This study included 105 patients with RA and 90 healthy volunteers. miR-383-5p was quantified by RT-qPCR. The diagnostic potential of miR-383-5p for RA was evaluated by the ROC curve. Chi-square analysis was performed to evaluate correlations between clinicopathological parameters and the miR-383-5p level in RA. Fibroblast-like synoviocytes (FLS) were isolated from synovial tissue. miR-383-5p was over-expressed or inhibited by transfection in FLS. ELISA was used to detect inflammatory factor expression. Pearson correlation analysis was utilized to detect the correlations. miR-383-5p was decreased in RA and may have a diagnostic value in RA. In patients with RA, miR-383-5p was closely related to erythrocyte sedimentation rate, C-reactive protein, anti-cyclic citrullinated peptide antibody positivity and rheumatoid factor. In addition, miR-383-5p was negatively correlated with inflammatory factors in RA. In FLS of RA, the over-expression of miR-383-5p decreased the inflammatory factors, while the inhibition of miR-383-5p increased the inflammatory factors. miR-383-5p may be associated with RA by involvement in the inflammatory response in FLS. Thus, miR-383-5p may show diagnostic potential in RA.<\/jats:p>","DOI":"10.14712\/fb2026.0014","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:58:57Z","timestamp":1780649937000},"page":"136-143","update-policy":"https:\/\/doi.org\/10.14712\/crossmark-policy-fb","source":"Crossref","is-referenced-by-count":0,"title":["Research on the Diagnostic Potential of miR-383-5p in Rheumatoid Arthritis"],"prefix":"10.14712","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7548-0709","authenticated-orcid":false,"given":"Baohui","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5569-8285","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2445-819X","authenticated-orcid":false,"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"fb2026.0014_1","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"key":"fb2026.0014_2","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.7150\/jca.89733","volume":"15","author":"Bi","year":"2024","journal-title":"J. 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