{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:27:07Z","timestamp":1762432027360},"reference-count":0,"publisher":"CMB Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol (Noisy-le-grand)"],"abstract":"<jats:p>The antidepressant activity of Spathodea campanulata flowers was evaluated in mice and in silico. When tested at doses of 200 and 400 mg\/kg, the methanol extract of S. campanulata (MESC) showed dose-dependent antidepressant activity in the force swim test (FST), tail suspension test (TST), lithium chloride-induced twitches test and the open field test. In FST and TST, animals treated with MESC demonstrated a significant decrease in the immobility period compared to the control group. The lithium chloride-induced head twitches were significantly reduced following administration of MESC. The latter, at the dose of 400 mg\/kg, also significantly reduced locomotor activity. Following administration of MESC, changes in the levels of serum corticosterone, and of norepinephrine, dopamine, serotonin, 4-hydroxy-3-methoxyphenylglycol (MHPG), 4-dihydroxyphenylacetic acid (DOPAC), and 5-hydroxyindoleacetic acid (5-HIAA) were measured in different brain regions using HPLC. The presence of spatheoside A (m\/z 541) and spatheoside B (m\/z 559) in MESC was detected using HPLC\/ESI-MS. These two iridoids demonstrated a high predictive binding affinity for the active site of the type A monoamine oxidase (MAO-A) enzyme with scores of 99.40 and 93.54, respectively.\u00a0 These data suggest that S. campanulata flowers warrants further investigation as a source of novel templates for antidepressive drugs.<\/jats:p>","DOI":"10.14715\/cmb\/2021.67.1.1","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T17:48:38Z","timestamp":1624816118000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Antidepressant activity of Spathodea campanulata in mice and predictive affinity of spatheosides towards type A monoamine oxidase"],"prefix":"10.14715","volume":"67","author":[{"given":"Jitendra","family":"Bajaj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya","family":"Dwivedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram","family":"Sahu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Dave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanika","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushil","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhawana","family":"Sati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swapnil","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronique","family":"Seidel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay Prakash","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5752","published-online":{"date-parts":[[2021,1,31]]},"container-title":["Cellular and Molecular Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/3932\/1761","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/3932\/1761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T11:31:07Z","timestamp":1642764667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/3932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,31]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,3,8]]}},"URL":"https:\/\/doi.org\/10.14715\/cmb\/2021.67.1.1","relation":{},"ISSN":["1165-158X","0145-5680"],"issn-type":[{"value":"1165-158X","type":"electronic"},{"value":"0145-5680","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1,31]]}}}