{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:56:17Z","timestamp":1766087777751},"reference-count":0,"publisher":"CMB Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol (Noisy-le-grand)"],"abstract":"<jats:p>The inflammatory reaction is one of the complications in patients with coronary atherosclerosis. This study aimed to determine the diagnostic value of platelet-activating factor (PAF) compared with high sensitivity C reactive protein (hs-CRP) in coronary atherosclerotic patients. Fifty patients with coronary atherosclerosis and 30 subjects with normal angiography were considered as the control group attending Cardiac Center-Surgical Specialty Hospital - in Erbil city \/ Iraq. The levels of PAF and hs-CRP were estimated quantitatively using a sandwich enzyme-linked immunosorbent assay and a particle-enhanced immune turbid metric assay, respectively. Lipid profiles and some hematological indexes were also used in this study. The levels of the inflammatory biomarkers of PAF and hs-CRP increased significantly in the patients group compared with controls (p&lt;0.05). Although the patients group showed the highest level of low-density lipoprotein (LDL), the difference was not significant (p&gt;0.05) compared with the healthy control. However, the incidence of risk factors such as smoking and obesity showed a significant difference (p&lt;0.05) in the patients group. Additionally, the PAF level correlated positively and significantly with hs-CRP (p&lt;0.05), and negatively with high-density lipoprotein (HDL) (p&gt;0.05). Although hs-CRP was a valuable diagnostic marker for coronary atherosclerosis, the PAF level showed to be a better prognostic indicator than hs-CRP in coronary atherosclerosis patients.<\/jats:p>","DOI":"10.14715\/cmb\/2021.67.3.1","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T06:28:44Z","timestamp":1637908124000},"page":"1-4","source":"Crossref","is-referenced-by-count":6,"title":["Investigating platelet-activating factor as a potent proinflammatory mediator in coronary atherosclerotic patients"],"prefix":"10.14715","volume":"67","author":[{"given":"Shler Ghafoor","family":"Raheem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5752","published-online":{"date-parts":[[2021,11,25]]},"container-title":["Cellular and Molecular Biology"],"original-title":[],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T06:28:44Z","timestamp":1637908124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/3995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,25]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,11,25]]}},"URL":"https:\/\/doi.org\/10.14715\/cmb\/2021.67.3.1","relation":{},"ISSN":["1165-158X","0145-5680"],"issn-type":[{"value":"1165-158X","type":"electronic"},{"value":"0145-5680","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11,25]]}}}