{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:23:57Z","timestamp":1773685437609,"version":"3.50.1"},"reference-count":0,"publisher":"CMB Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol (Noisy-le-grand)"],"abstract":"<jats:p>Type 1 diabetes mellitus, also called insulin-dependent diabetes is associated with elevated blood glucose concentration arising from the inability of the pancreas to produce insulin. Diabetic cardiomyopathy is a major cause of death in diabetic patients. CircRNAs have been reported to participate in various human diseases, including diabetic cardiomyopathy. In this study, the regulation network of circRNA in type 1 diabetes mellitus was investigated. Streptozotocin treatment was implemented to induce type 1 diabetes mellitus in the mouse model, and echocardiography was implemented to detect the heart function of the type 1 diabetes mellitus mouse. Also, the qRT-PCR assay was used to identify the circRNA expression in type 1 diabetes mellitus mouse myocardial tissue. Findings showed that heart function of type 1 diabetes mellitus mouse was significantly damaged than control group mouse and cardiac hypertrophy in type 1 diabetes mellitus mouse, circRNAs were aberrantly regulated in type 1 diabetes mellitus mouse myocardial tissue. The following circRNAs were mmu_circ_0001560, mmu_circ_0001800, mmu_circ_0001801, mmu_circ_0002281 and mmu_circ_0000614 were expressed low in type 1 diabetes mellitus mouse myocardial tissue. In conclusion, type 1 diabetes mellitus caused alterations in the regulation network of circRNAs.<\/jats:p>","DOI":"10.14715\/cmb\/2021.67.3.32","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T06:27:31Z","timestamp":1637908051000},"page":"201-203","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of circRNA regulatory network in myocardial tissue of type 1 diabetic mice"],"prefix":"10.14715","volume":"67","author":[{"given":"Jianjun","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5752","published-online":{"date-parts":[[2021,11,25]]},"container-title":["Cellular and Molecular Biology"],"original-title":[],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T06:27:31Z","timestamp":1637908051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,25]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,11,25]]}},"URL":"https:\/\/doi.org\/10.14715\/cmb\/2021.67.3.32","relation":{},"ISSN":["1165-158X","0145-5680"],"issn-type":[{"value":"1165-158X","type":"electronic"},{"value":"0145-5680","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11,25]]}}}