{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:50:59Z","timestamp":1788292259512,"version":"build-2803163510"},"reference-count":0,"publisher":"CMB Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol (Noisy-le-grand)"],"abstract":"<jats:p>Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus, often leading to heart failure, arrhythmias and sudden death. Long-stranded non-coding RNA (LncRNA), an endogenous non-coding long-stranded RNA, is associated with diabetic cardiomyopathy. However, the mechanism of LncRNA regulation of cellular scorching in diabetic cardiomyopathy remains unclear. This study aimed to elucidate whether MALAT 1 affects cardiomyocyte scorching in DCM patients. Methods: Streptozotocin (STZ) at 35 mg\/Kg was used to induce diabetes in rats. H9C2 cardiomyocytes and primary cardiomyocytes (PCM) were cultured at 5.5 and 50 mmol\/L glucose, respectively. The expression levels of MALAT 1 and scorch death-related genes were detected by RT-PCR using plasmids to suppress or overexpress the related genes, respectively. Immunofluorescence, RT-PCR and Western blot were used to detect the extent of cell scorch death. RESULTS: MALAT 1 expression was elevated in diabetic and high glucose-induced cardiomyocytes and myocardial tissue from diabetic mice (p&lt;0.001). Silencing of MALAT 1 alleviated cardiomyocyte scorch death by targeting NLRP3. Furthermore, silencing MALAT 1 reduced cell death and improved cardiac function and morphology. CONCLUSIONS: MALAT 1 is overexpressed in DCM and silencing MALAT 1 inhibits cell scorch death by affecting NLRP3 expression. We clarify for the first time that MALAT 1 may be a new therapeutic target for DCM.<\/jats:p>","DOI":"10.14715\/cmb\/2021.67.6.28","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T13:58:11Z","timestamp":1646056691000},"page":"213-219","source":"Crossref","is-referenced-by-count":16,"title":["LncRNA-MALAT 1 regulates cardiomyocyte scorching in diabetic cardiomyopathy by targeting NLRP3"],"prefix":"10.14715","volume":"67","author":[{"given":"Chang","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5752","published-online":{"date-parts":[[2022,2,27]]},"container-title":["Cellular and Molecular Biology"],"original-title":[],"link":[{"URL":"http:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4171\/1990","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4171\/1990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T13:03:36Z","timestamp":1650546216000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,27]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,2,27]]}},"URL":"https:\/\/doi.org\/10.14715\/cmb\/2021.67.6.28","relation":{},"ISSN":["1165-158X","0145-5680"],"issn-type":[{"value":"1165-158X","type":"electronic"},{"value":"0145-5680","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,27]]}}}