{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:42:20Z","timestamp":1784079740003,"version":"3.55.0"},"reference-count":0,"publisher":"CMB Association","issue":"2","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol (Noisy-le-grand)"],"abstract":"<jats:p>The purpose of this study was to investigate the effects of propofol anesthesia combined with\nremifentanil on inflammation, stress response, and immune function in children undergoing tonsil and\nadenoid surgery. For this aim, 126 children admitted to our hospital for elective temperature-controlled\nradio-frequency of tonsils and adenoids from October 2020 to September 2021 were randomly divided\ninto an observation group (n=63) and a control group (n=63). The observation group was anesthetized\nwith propofol in combination with remifentanil, while the control group underwent propofol combined\nwith ketamine. The mean arterial pressure (MAP), heart rate, serum C-reactive protein (CRP),\ninterleukin-6 (IL-6), tumour necrosis factor-\u03b1 (TNF-\u03b1), epinephrine, cortisol (Cor), CD3+ T\nlymphocytes, CD4+ helper T lymphocytes, CD8+ suppressor T lymphocytes and CD4+\/CD8+ ratio were\ncompared between the two groups before induction of anaesthesia (T1), upon intubation (T2), at the\nbeginning of surgery (T3), at the end of surgery (T4) and 5 min after extubation (T5). -(TNF-\u03b1). The\nrecovery time from anaesthesia and adverse reactions after extubation were observed in the two groups.\nResults showed that the MAP and heart rate in both groups increased significantly at T2 compared to T1,\nbut the observation group had lower values than the control group after the maintenance of anaesthesia\n(P&lt;0.05). Serum CRP, IL-6 and TNF-\u03b1 levels increased with time in both groups, and the increase was\nconsidered significant (P&lt;0.05). In addition, serum epinephrine and Cor levels gradually rose from T1 to\nT4 in both groups, and then decreased at T5. The difference was statistically significant (P&lt;0.05)\nbetween any two-time points. CRP, IL-6, TNF-\u03b1, epinephrine and Cor in the observation group were\nsignificantly lower than those in the control group from T3 to T5 (P&lt;0.05). CD3+, CD4+ and\nCD4+\/CD8+ ratio decreased whereas CD8+ went up in both groups at T4 and T5, and which were\nconsidered statistically significant when compared with data from T1 to T3 (P&lt;0.05). However, CD3+,\nCD4+, CD8+ and CD4+\/CD8+ ratios did not differ statistically significantly between the two groups at\neach time point (P&gt;0.05). In the observation group, the time to recovery of spontaneous respiration, the\ntime to resumption of limb movements and the span from discontinuation of anaesthetic to extubation\nwere all significantly shorter than those in the control group, and the incidence of agitation during the\nawakening period was lower than that in the control group (P&lt;0.05). Then propofol combined with\nremifentanil is more effective in inflammation, stress response and immune function in anesthetizing\nchildren undergoing tonsil and adenoid surgery. The observation group presented more stable\nhemodynamics, lower levels of inflammation and stress reactions, rapid awakening and fewer adverse\neffects, so the combination therapy was worthy of clinical promotion in pediatric surgery requiring\ngeneral anesthesia.<\/jats:p>","DOI":"10.14715\/cmb\/2022.68.2.13","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T17:56:21Z","timestamp":1659203781000},"page":"87-93","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Propofol anesthesia combined with remifentanil on inflammation, stress\nresponse and immune function in children undergoing tonsil and adenoid surgery"],"prefix":"10.14715","volume":"68","author":[{"family":"Xiaoqin Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Xuechun Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Bin Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Zaiping Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Xianlin Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Shaowu Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5752","published-online":{"date-parts":[[2022,2,28]]},"container-title":["Cellular and Molecular Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4278\/2050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4278\/2050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T17:56:49Z","timestamp":1659203809000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6,8]]}},"URL":"https:\/\/doi.org\/10.14715\/cmb\/2022.68.2.13","relation":{},"ISSN":["1165-158X","0145-5680"],"issn-type":[{"value":"1165-158X","type":"electronic"},{"value":"0145-5680","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,28]]}}}