{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T23:22:09Z","timestamp":1772061729802,"version":"3.50.1"},"reference-count":0,"publisher":"CMB Association","issue":"2","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol (Noisy-le-grand)"],"abstract":"<jats:p>Diabetes is associated with reproductive impairment in the male reproductive system and causes\ncomplications such as decreased libido, fertility, spermatogenesis, sperm motility, and morphology. High\nlevels of blood sugar may affect sperm quality and reduce the potential for male fertility. Increased levels\nof sperm DNA damage are often associated with reduced count and motility or abnormal morphology.\nThis experimental study was conducted at Mashhad University of Medical Sciences. In this work, 40 mice\n(C57BL\/6) were divided randomly into 4 groups: 1) Control, 2) Diabetic, 3) Diabetic + Insulin, and 4)\nSham. After 35 days, the right epididymis of all specimens was used for Real-Time PCR and the left\nepididymis for evaluation of sperm parameters using Aniline blue, Toluidine blue, Papanicolaou, and\nimmunohistochemical study. Also, testes were applied for immunohistochemical, TUNEL studies, and\nbiochemical assay. Results of this study showed that chromatin integrity, morphology, cation channels\nof sperm (Catsper) expression, and biochemical factors level were significantly changed in diabetic mice\nin comparison to other groups (P&lt;0.05) and treatment with insulin improved these parameters. Our\nfindings showed that the sperm parameters such as DNA integrity, morphology, and Catsper expression\nchange in diabetic mice.<\/jats:p>","DOI":"10.14715\/cmb\/2022.68.2.2","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T17:56:21Z","timestamp":1659203781000},"page":"8-18","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of sperm chromatin\/DNA integrity, morphology, and Catsper expression\non diabetic C57BL\/6 mice"],"prefix":"10.14715","volume":"68","author":[{"family":"Elnaz Khordad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Mohammad Reza  Nikravesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Mahdi  Jalali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Alireza  Fazel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Mojtaba  Sankian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Fatemeh Alipour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5752","published-online":{"date-parts":[[2022,2,28]]},"container-title":["Cellular and Molecular Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4286\/2039","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4286\/2039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T17:56:38Z","timestamp":1659203798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6,8]]}},"URL":"https:\/\/doi.org\/10.14715\/cmb\/2022.68.2.2","relation":{},"ISSN":["1165-158X","0145-5680"],"issn-type":[{"value":"1165-158X","type":"electronic"},{"value":"0145-5680","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,28]]}}}