{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:49:36Z","timestamp":1762325376859},"reference-count":0,"publisher":"CMB Association","issue":"2","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol (Noisy-le-grand)"],"abstract":"<jats:p>It was to investigate the diagnostic value of keratin 7 (KRT7) in malignant metastasis of epithelial\novarian cancer and benign epithelial ovarian tumors. From January 2018 to January 2019, 30 fresh\ntissues of benign epithelial ovarian tumors, 30 fresh tissues of borderline tumors, 30 fresh tissues of\nmetastatic ovarian were collected in The First Affiliated Hospital of Fujian Medical University, and 30\nfresh tissues of normal ovarian tissues were collected as the control group. Federation of gynecology\nand obstetrics (FIGO) staging criteria: 25 cases of stage I, 26 cases of stage II, 16 cases of stage III, and\n23 cases of stage IV. The relative expression of KRT7 was detected by real-time fluorescence\nquantitative PCR, and the relationship between KRT7 expression and epithelial ovarian cancer grading\nwas analyzed. The results showed that the positive expression rate of KRT7 was 12.1% in normal\novarian tissues, 28.4% in benign epithelial ovarian tumors, 53.5% in borderline tumors, and 24.2% in\nmetastatic ovarian cancer. With the increase of tumor stage malignancy, the relative expression of\nKRT7 decreased significantly, but there was no significant difference between stage I and stage II, stage\nIII and stage IV (P &gt; 0.05). The difference between stage I and stage III, and stage IV was significant (P\n&lt; 0.05). Patients with epithelial ovarian cancer had a significant difference compared with the control\ngroup (P &lt; 0.05). In summary, compared with the control group, the expression of KRT7 in patients\nwith benign epithelial ovarian tumors and borderline tumors was significantly decreased. The expression\nlevel of KRT7 in benign epithelial ovarian tumors was lower than that in borderline tumors. The\nexpression of KRT7 was related to the occurrence, development, and deterioration of ovarian cancer,\nwhich provided a basis for targeted therapy of tumors.<\/jats:p>","DOI":"10.14715\/cmb\/2022.68.2.22","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T16:51:37Z","timestamp":1659199897000},"page":"153-161","source":"Crossref","is-referenced-by-count":5,"title":["Expression Level of Keratin 7 in Epithelial Ovarian Cancer and Malignant\nMetastasis of Benign Epithelial Ovarian Tumors"],"prefix":"10.14715","volume":"68","author":[{"family":"Minghui Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jinhua Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Shaoyu Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Yuxiu Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5752","published-online":{"date-parts":[[2022,2,28]]},"container-title":["Cellular and Molecular Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4298\/2059","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4298\/2059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T16:51:40Z","timestamp":1659199900000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4298"}},"subtitle":[""],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6,8]]}},"URL":"https:\/\/doi.org\/10.14715\/cmb\/2022.68.2.22","relation":{},"ISSN":["1165-158X","0145-5680"],"issn-type":[{"value":"1165-158X","type":"electronic"},{"value":"0145-5680","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,28]]}}}