{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:05:25Z","timestamp":1782745525360,"version":"3.54.5"},"reference-count":0,"publisher":"CMB Association","issue":"2","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol (Noisy-le-grand)"],"abstract":"<jats:p>The study aimed to explore the effects of the ultrasound-guided thoracic paravertebral block (TPVB) on\nthe inflammatory response, stress response, hemodynamics and anesthesia resuscitation in gallbladder\ncarcinoma. Eighty gallbladder carcinoma patients undergoing open cholecystectomy in Heilongjiang\nProvincial Hospital from February 2016 to April 2019 were selected and divided into observation group\n(n=40) and control group (n=40) using a random number table. All patients underwent open\ncholecystectomy under general anesthesia and tracheal intubation. Patient-controlled intravenous\nanalgesia was adopted after the operation in the control group, while right TPVB was performed before\ngeneral anesthesia in the observation group. The changes in inflammatory factors and oxidative stress\nfactors were compared between the two groups, the anesthesia resuscitation indexes, and the changes in\nthe bispectral index (BIS) and Ramsay score during anesthesia resuscitation were recorded, and the\nchanges in the hemodynamic indexes in perianesthesia and anesthesia resuscitation-related\ncomplications were analyzed. At 15 min after anesthesia, the observation group had lower levels of\ninflammatory factors high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) (p&lt;0.05),\nmalondialdehyde (MDA) (p&lt;0.05) and a higher level of superoxide dismutase (SOD) (p&lt;0.05) than the\ncontrol group. The anesthesia resuscitation time was shorter in the observation group than that in the\ncontrol group (p&lt;0.05). At 10 min, 20 min and 30 min after anesthesia, both BIS and Ramsay scores\nwere significantly higher in the observation group than those in the control group (p&lt;0.05). Moreover,\nthe proportion of circulatory function-related complications and anesthesia resuscitation-related\ncomplications were lower in the observation group than that in the control group (p&lt;0.05). The NRS\nscore in the observation group was lower than that in the control group after anesthesia (p&lt;0.05). TPVB\nin perianesthesia for gallbladder carcinoma patients can effectively lower the body's inflammatory and\nstress responses, promote anesthesia resuscitation, reduce complications in perianesthesia, and relieve\npostoperative pain.<\/jats:p>","DOI":"10.14715\/cmb\/2022.68.2.24","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T16:51:37Z","timestamp":1659199897000},"page":"171-177","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Thoracic Paravertebral Block on Inflammatory Response, Stress Response,\nHemodynamics and Anesthesia Resuscitation in Gallbladder Carcinoma"],"prefix":"10.14715","volume":"68","author":[{"family":"Dunhua Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Haiyan Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Jun Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Bing Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5752","published-online":{"date-parts":[[2022,2,28]]},"container-title":["Cellular and Molecular Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4299\/2061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4299\/2061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T16:51:37Z","timestamp":1659199897000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6,8]]}},"URL":"https:\/\/doi.org\/10.14715\/cmb\/2022.68.2.24","relation":{},"ISSN":["1165-158X","0145-5680"],"issn-type":[{"value":"1165-158X","type":"electronic"},{"value":"0145-5680","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,28]]}}}