{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:34:03Z","timestamp":1767598443895},"reference-count":0,"publisher":"CMB Association","issue":"2","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol (Noisy-le-grand)"],"abstract":"<jats:p>Streptococcus pneumoniae is a common cause of bacterial infections of the respiratory system, middle\near infection, bacteremia, meningitis, and pneumonia, especially in children. Due to the lack of\ninformation about the frequency and resistance of Streptococcus pneumoniae to antibiotics, the present\nstudy was performed to determine the frequency of carriers of Streptococcus pneumoniae and its\nmicrobial resistance in children. For this purpose, the current descriptive cross-sectional study was\nconducted from November to March 2020 on 554 children aged 2-12 years in kindergartens and\nschools. This study collected samples with a sterile swab from the nasopharyngeal region, transported\nthem to the laboratory by a transport medium, and then cultured them on an agar culture medium. After\nisolation, confirmatory tests and antibiotic susceptibility were performed. The results were analyzed\nusing SPSS16 software and interpreted according to Mann Whitney U and Chi-Square Tests.\nStreptococcus pneumoniae was found in 15% of samples, and the antibiotic resistance of the isolates to\nthe antibiotics azithromycin, amoxicillin, rifampicin, amoxicillin-clavulanic acid,\ntrimethoprim\/Sulfamethoxazole, and ceftriaxone were 63.9%, 56.6%, 41%, 37.3%, 37.3%, and 3.6%,\nrespectively. Also, 31.1% of the isolates were not resistant to any antibiotics. According to the results,\nexcessive use of antibiotics has led to high resistance to azithromycin, amoxicillin,\namoxicillin\/clavulanic acid, and trimethoprim\/Sulfamethoxazole, which indicates an increased risk of\nrefractory infectious diseases. For this reason, it is necessary to adequately educate physicians and the\ngeneral public about the overuse of antibiotics.<\/jats:p>","DOI":"10.14715\/cmb\/2022.68.2.29","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T17:56:21Z","timestamp":1659203781000},"page":"203-207","source":"Crossref","is-referenced-by-count":4,"title":["Determining the frequency of Streptococcus pneumoniae carriers and its microbial\nresistance in children"],"prefix":"10.14715","volume":"68","author":[{"family":"Langhuan  Lei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Xingyong Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5752","published-online":{"date-parts":[[2022,2,28]]},"container-title":["Cellular and Molecular Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4290\/2066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4290\/2066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T17:56:32Z","timestamp":1659203792000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6,8]]}},"URL":"https:\/\/doi.org\/10.14715\/cmb\/2022.68.2.29","relation":{},"ISSN":["1165-158X","0145-5680"],"issn-type":[{"value":"1165-158X","type":"electronic"},{"value":"0145-5680","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,28]]}}}