{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:20:55Z","timestamp":1785280855968,"version":"3.55.0"},"reference-count":0,"publisher":"CMB Association","issue":"2","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol (Noisy-le-grand)"],"abstract":"<jats:p>The aetiology of oral lichen planus (OLP) is multifactorial, having variable triggers. A role for vitamin\nD related to the immune system has been established. Vitamin D modulating effect is on the adaptive\nand innate immune responses. Our study aimed to compare serum levels of vitamin D in patients having\ndifferent clinical symptoms of OLP (symptomatic or asymptomatic) with healthy individuals. Also, in\nthis study, for further evaluation, the expression level of interleukin-17A and interleukin-6 (IL-17A and\nIL-6) was evaluated because the presence of active vitamin D reduces the expression of these proinflammatory\nfactors. This study was included three groups with 30 volunteers in each. The first group\nincluded asymptomatic oral lichen planus patients (reticular or plaque-like lesions). The second group\nconsisted of symptomatic oral lichen planus patients (atrophic or bullous-erosive lesions). In contrast,\nthe third group consisted of healthy control subjects. The serum 25-hydroxyvitamin D was measured\nbetween the three groups and then correlated with clinical manifestation of oral lichen planus, either\nsymptomatic or non-symptomatic. The Real-Time PCR technique was used to evaluate the expression\nof IL-17A and IL-6. Patients with symptomatic OLP (second group) had statistically significantly lower\nVitamin D levels than asymptomatic OLP patients (first group). Healthy Controls (third group)\nexhibited statistically significantly higher vitamin D levels than OLP groups. The results of IL-17A and\nIL-6 genes expression showed that the presence of vitamin D had a statistically significant effect on\nreducing the expression of these two pro-inflammatory cytokines among symptomatic and\nasymptomatic OLP patients. Also, the results showed that there was a statistically significant difference\nbetween OLP patients (group I and II) and the control group (group III). In general, the current study\nresults showed that lack of vitamin D had an important role in initiating or increasing the OLP's\nseverity.<\/jats:p>","DOI":"10.14715\/cmb\/2022.68.2.3","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T17:56:21Z","timestamp":1659203781000},"page":"19-25","source":"Crossref","is-referenced-by-count":8,"title":["Serum vitamin D level in healthy individuals versus patients with symptomatic and\nasymptomatic oral lichen planus"],"prefix":"10.14715","volume":"68","author":[{"family":"Marssafy Lama H.","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Fatma Hussein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Hesham Sadek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Wahdan Abdelghany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5752","published-online":{"date-parts":[[2022,2,28]]},"container-title":["Cellular and Molecular Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4285\/2040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4285\/2040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T17:56:40Z","timestamp":1659203800000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6,8]]}},"URL":"https:\/\/doi.org\/10.14715\/cmb\/2022.68.2.3","relation":{},"ISSN":["1165-158X","0145-5680"],"issn-type":[{"value":"1165-158X","type":"electronic"},{"value":"0145-5680","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,28]]}}}