{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T18:13:25Z","timestamp":1659204805914},"reference-count":0,"publisher":"CMB Association","issue":"2","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol (Noisy-le-grand)"],"abstract":"<jats:p>This study was developed to investigate the expression of TOLL2, TARC and MDC in placenta tissue\nof pregnant patients infected with syphilis and their clinical significance. For this aim, placenta samples\nwere collected from five pregnant patients co-infected with syphilis and five undergoing full-term\ndelivery before RT-PCR was performed to detect the mRNA expression of TLR2, TARC and MDC\ngenes. The protein expression of TLR2, TARC and MDC genes was examined by Western Blotting.\nResults showed that TLR2, TARC and MDC were expressed in placental syncytiotrophoblast cells of\npatients with pregnancy-associated syphilis infection. TLR2 level was found significantly higher in\nplacenta tissue of patients with pregnancy-associated syphilis infection compared with normal placenta\ntissue (P&lt;0.05), so were TARC (P&lt;0.05) and MDC genes (P&lt;0.05). It is concluded that TOLL2, TARC\nand MDC levels significantly increased in the placenta tissue of pregnant patients infected with syphilis,\nsuggesting that the three genes were involved in the molecular pathology of the patients.<\/jats:p>","DOI":"10.14715\/cmb\/2022.68.2.8","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T17:56:21Z","timestamp":1659203781000},"page":"54-59","source":"Crossref","is-referenced-by-count":0,"title":["Expression and significance of TOLL2, TARC and MDC in placenta tissue of\npregnant patients infected with syphilis"],"prefix":"10.14715","volume":"68","author":[{"family":"Juan  Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"An'er Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5752","published-online":{"date-parts":[[2022,2,28]]},"container-title":["Cellular and Molecular Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4274\/2045","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/download\/4274\/2045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T17:56:54Z","timestamp":1659203814000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6,8]]}},"URL":"https:\/\/doi.org\/10.14715\/cmb\/2022.68.2.8","relation":{},"ISSN":["1165-158X","0145-5680"],"issn-type":[{"value":"1165-158X","type":"electronic"},{"value":"0145-5680","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,28]]}}}