{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:01:41Z","timestamp":1790233301730,"version":"4.1.0"},"reference-count":0,"publisher":"Kare Publishing","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/anatoljcardiol.com\/storage\/upload\/pdfs\/1790230444-en.pdf"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,24]]},"abstract":"<jats:p>Objective: The cardiovascular effects of sodium\u2013glucose cotransporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors have attracted increasing interest in patients with type 2 diabetes mellitus. This study aimed to compare the time-dependent effects of empagliflozin and linagliptin on left ventricular diastolic function and global longitudinal strain (GLS).\n\nMethods: This prospective longitudinal study included 350 patients with type 2 diabetes mellitus treated with empagliflozin (n = 200) or linagliptin (n = 150). Transthoracic echocardiography and speckle-tracking strain analysis were performed at baseline, 1 month, and 6 months. Diastolic function was evaluated using septal e\u2032 velocity, E\/e\u2032 ratio, isovolumetric relaxation time (IVRT), and mitral E-wave deceleration time. Longitudinal changes were analyzed using linear mixed-effects models including treatment group,\ntime, and group \u00d7 time interaction.\n\nResults: Diastolic function parameters improved significantly over time in both groups (all\nP &lt; .001). At follow-up, HbA1c levels decreased in both groups, with comparable glycemic control achieved at 6 months. Significant group \u00d7 time interactions were observed for septal e\u2032 velocity, E\/e\u2032 ratio, and IVRT (all P &lt; .001). These findings remained consistent after adjustment for baseline differences. At 6 months, empagliflozin was associated\nwith greater improvement in septal e\u2032 velocity and IVRT, whereas linagliptin resulted in a more pronounced reduction in the E\/e\u2032 ratio. Although GLS improved in both groups, its temporal pattern differed significantly between treatments (P &lt; .001).\n\nConclusion: Empagliflozin and linagliptin exert distinct effects on left ventricular diastolic function and myocardial deformation in type 2 diabetes mellitus. Empagliflozin appears to provide earlier improvement in diastolic relaxation and GLS, whereas linagliptin may have a greater effect on filling pressures. These findings should be interpreted cautiously and considered hypothesis-generating; confirmation in randomized controlled trials is required to determine their clinical relevance.<\/jats:p>","DOI":"10.14744\/anatoljcardiol.2026.6348","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:34:54Z","timestamp":1790231694000},"page":"700","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Assessment of Diastolic Function and Myocardial Strain in Type 2 Diabetes: A Comparison of Empagliflozin and Linagliptin"],"prefix":"10.14744","author":[{"given":"O\u011fuz Kaan","family":"Kaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"K\u00f6ker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5966","published-online":{"date-parts":[[2026,9,24]]},"container-title":["The Anatolian Journal of Cardiology"],"original-title":[],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:34:54Z","timestamp":1790231694000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatoljcardiol.com\/article\/AJC-57569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.14744\/anatoljcardiol.2026.6348","relation":{},"ISSN":["2149-2263","2149-2271"],"issn-type":[{"value":"2149-2263","type":"print"},{"value":"2149-2271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]}}}