{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:33:20Z","timestamp":1793946800196,"version":"4.8.0"},"reference-count":0,"publisher":"Kare Publishing","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anatol J Cardiol"],"abstract":"<jats:p>Background: Although transcatheter aortic valve implantation (TAVI) outcomes are well-documented, predictors of mortality beyond conventional surgical risk scores and valve-related factors in real-world, high-risk cohorts require further elucidation. This study aimed to identify the key determinants of 30-day and 1-year mortality following TAVI, with a focus on both patient-specific and procedure-specific complications.\n\nMethods: The KOSUTAVI study is a single-center, retrospective cohort analysis of 859 consecutive high-risk individuals with severe aortic stenosis undergoing TAVI between 2020 and 2025. Primary endpoints were 30-day and 1-year all-cause mortality. Multivariate Cox regression and Kaplan\u2013Meier analyses were used to identify independent risk factors.\n\nResults: Mean age was 78.7 \u00b1 6.5 years, and mean Society of Thoracic Surgeons score was 7.4 \u00b1 2.2. The 30-day and 1-year mortality rates were 6.5% (n = 56) and 12.4% (n = 107), respectively. The 5-year all-cause mortality rate was 26.3%. In multiple Cox\u2019s analysis,  chronic renal failure (hazard ratio [HR] = 7.75, P = .008, 95% CI = 1.29-16.54), presentation with cardiogenic shock (HR = 5.83, P = .028, 95% CI = 1.19-15.41), major vascular injury (HR = 22.7, P = .019, 95% CI = 1.89-45.91), and cardiac tamponade (HR = 17.9, P = .012, 95% CI = 8.13-52.62) were independently associated with 30-day mortality. While these factors were all significant in univariate analysis for 1-year mortality, they did not retain independence in the multiple model. Valve type, access route, and sex were not associated with increased mortality.\n\nConclusion: In a high-risk TAVI population, early mortality is predominantly driven by pre-existing renal dysfunction and acute procedural complications (shock, vascular injury, and tamponade), rather than valve-specific factors. These findings underscore the critical importance of optimizing renal function before the procedure and implementing advanced vascular protection strategies to improve early survival after TAVI.<\/jats:p>","DOI":"10.14744\/anatoljcardiol.2026.6567","type":"journal-article","created":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:14:53Z","timestamp":1793945693000},"source":"Crossref","is-referenced-by-count":0,"title":["Early and Mid-Term Mortality After Transcatheter Aortic Valve Implantation: Five-Year Experience from the KOSUTAVI Study"],"prefix":"10.14744","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2729-884X","authenticated-orcid":false,"given":"Regayip","family":"Zehir","sequence":"first","affiliation":[{"name":"Department of Cardiology, Kartal Ko\u015fuyolu High Specialization Training and Research Hospital, University of Health Sciences, \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6952-7386","authenticated-orcid":false,"given":"Elnur","family":"Alizade","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kartal Ko\u015fuyolu High Specialization Training and Research Hospital, University of Health Sciences, \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9572-5431","authenticated-orcid":false,"given":"Song\u00fcl","family":"Usalp","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kartal Ko\u015fuyolu High Specialization Training and Research Hospital, University of Health Sciences, \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3873-8997","authenticated-orcid":false,"given":"Mehmet\u00a0Yunus","family":"Emiro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kartal Ko\u015fuyolu High Specialization Training and Research Hospital, University of Health Sciences, \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4231-7412","authenticated-orcid":false,"given":"Ramazan","family":"Karg\u0131n","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kartal Ko\u015fuyolu High Specialization Training and Research Hospital, University of Health Sciences, \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6337-7716","authenticated-orcid":false,"given":"Nihal","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kartal Ko\u015fuyolu High Specialization Training and Research Hospital, University of Health Sciences, \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9986-050X","authenticated-orcid":false,"given":"Cevat","family":"K\u0131rma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kartal Ko\u015fuyolu High Specialization Training and Research Hospital, University of Health Sciences, \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2627-9081","authenticated-orcid":false,"given":"Cihangir","family":"Kaymaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kartal Ko\u015fuyolu High Specialization Training and Research Hospital, University of Health Sciences, \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8588-4583","authenticated-orcid":false,"given":"Mehmet\u00a0Muhsin","family":"T\u00fcrkmen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kartal Ko\u015fuyolu High Specialization Training and Research Hospital, University of Health Sciences, \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3523-1573","authenticated-orcid":false,"given":"Sel\u00e7uk","family":"Pala","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kartal Ko\u015fuyolu High Specialization Training and Research Hospital, University of Health Sciences, \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6435-7821","authenticated-orcid":false,"given":"\u015eeyhmus","family":"K\u00fclah\u00e7\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kartal Ko\u015fuyolu High Specialization Training and Research Hospital, University of Health Sciences, \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0044-4691","authenticated-orcid":false,"given":"Mehmet\u00a0Kaan","family":"K\u0131rali","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Kartal Ko\u015fuyolu High Specialization Training and Research Hospital, University of Health Sciences, \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5966","published-online":{"date-parts":[[2026]]},"container-title":["The Anatolian Journal of Cardiology"],"original-title":[],"link":[{"URL":"https:\/\/file.paplino.com\/anatoljcardiol\/pdfs\/1792573797-en.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:14:53Z","timestamp":1793945693000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatoljcardiol.com\/article\/AJC-96614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"URL":"https:\/\/doi.org\/10.14744\/anatoljcardiol.2026.6567","relation":{},"ISSN":["2149-2271","2149-2263"],"issn-type":[{"value":"2149-2271","type":"print"},{"value":"2149-2263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}