{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T03:57:41Z","timestamp":1769140661884,"version":"3.49.0"},"reference-count":0,"publisher":"Caleo","issue":"4","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Endod J."],"abstract":"<jats:p>This double-blinded randomised clinical trial aimed to compare the efficacy of lignocaine, diclofenac sodium and ketorolac tromethamine as supplemental intraligamentary injections for intra-appointment pain in normotensive and hypertensive patients with moderate to severe symptomatic irreversible pulpitis. Methodology: Ethical clearance was obtained, and the trial was registered on the Clinical Trial Registry India (CTRI\/2020\/09\/027635; Registered on 07\/09\/2020). A total of 198 patients were divided into two groups\u2014hypertensive group (Group 1; n=99) and normotensive (healthy) group (Group 2; n=99). After computerised randomisation and double blinding, participants were subdivided into three subgroups\u20141A\/2A: lignocaine (n=33), 1B\/2B: diclofenac sodium (n=33) and 1C\/2C: ketorolac tromethamine (n=33). The preoperative visual analogue scale (VAS) scores was recorded. For the hypertensive group, blood pressure was recorded, and inferior alveolar nerve block (IANB) comprising 1.8ml of 2% lignocaine without adrenaline was administered. For the normotensive group, IANB with 1.8ml of 2% lignocaine with adrenaline was administered. A supplemental intraligamentary injection comprising one of the experimental drugs was injected to both the groups. Endodontic access was gained, and the intraoperative VAS score was recorded. As part of the statistical analysis, paired t-tests, Tukey\u2019s post hoc test and ANOVA were performed using SPSS software version 20.Results: Supplemental intraligamentary injections of diclofenac sodium and ketorolac tromethamine showed a statistically significant difference (p<\/jats:p>","DOI":"10.14744\/eej.2024.71473","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T04:40:48Z","timestamp":1728448848000},"page":"278-284","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Anaesthetic Efficacies of Three Different Formulations of Intraligamentary Injections for Hypertensive Patients with Symptomatic Irreversible Pulpitis: A Randomised Controlled Trial"],"prefix":"10.65717","volume":"10","author":[{"given":"Meghna Anil","family":"Kothari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimisha Chinmay","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidambur Vasudev","family":"Ballal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lora","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay Singh","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"55248","published-online":{"date-parts":[[2025,7,16]]},"container-title":["European Endodontic Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.eurendodj.com\/index.php\/pub\/article\/download\/346\/346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurendodj.com\/index.php\/pub\/article\/download\/346\/346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:16:42Z","timestamp":1769084202000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurendodj.com\/index.php\/pub\/article\/view\/346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,16]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,7,16]]}},"URL":"https:\/\/doi.org\/10.14744\/eej.2024.71473","relation":{},"ISSN":["2548-0839"],"issn-type":[{"value":"2548-0839","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,16]]}}}