{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:32:06Z","timestamp":1793147526432,"version":"4.5.0"},"reference-count":0,"publisher":"Kare Publishing","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Forum"],"abstract":"<jats:p>Background and Aim: Several studies have suggested that treatment with direct-acting antivirals (DAAs) in patients with chronic hepatitis C virus (HCV) may be associated with an increased risk of developing hepatocellular carcinoma (HCC). We investigated the incidence and risk factors of HCC in HCV patients who achieved a sustained virologic response (SVR) following DAA therapies.\r\nMaterials and Methods: The medical data of patients who were diagnosed with HCV and received DAA therapy in two tertiary centers in Turkey were retrospectively collected.\r\nResults: Among them, 75 patients (52.4%) were noncirrhotic and 68 patients (47.6%) were cirrhotic. The overall SVR rate was 97.2% (139\/143). It was 100% in noncirrhotic and 94.1% in cirrhotic patients. HCC was developed in 5 (7.4%) patients, all of whom had baseline cirrhosis. The annual rate of HCC occurrence was 2.94%, and the 5-year cumulative incidence of HCC was 7.3%. The mean Child-Pugh score (CPS) and Model for End-Stage Liver Disease (MELD) score significantly decreased after DAA treatment (CPS 7.0 vs 5.9, p=0.001; MELD 10.8 vs 9.5, p=0.003).\r\nConclusion: There was no significant increase in the rate of HCC in cirrhotic HCV patients treated with DAAs. This treatment led to a remarkably high SVR rate and lowered CPS and MELD scores in cirrhotic HCV patients.<\/jats:p>","DOI":"10.14744\/hf.2022.2022.0016","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T06:30:04Z","timestamp":1663741804000},"page":"82-87","source":"Crossref","is-referenced-by-count":2,"title":["Development of hepatocellular carcinoma in patients with chronic hepatitis C who had sustained viral response following direct-acting antiviral therapy"],"prefix":"10.14744","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0012-2505","authenticated-orcid":false,"given":"Berat","family":"Ebik","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, University of Health Sciences, Diyabakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1473-2926","authenticated-orcid":false,"given":"Mustafa","family":"Aygan","sequence":"additional","affiliation":[{"name":"Deparment of Internal Medicine, Dicle University School of Medicine, Diyarbakir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0908-1949","authenticated-orcid":false,"given":"Elif Tugba","family":"Tuncel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ministry of Health Manisa City Hospital, Manisa, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6788-3459","authenticated-orcid":false,"given":"Huseyin","family":"Kacmaz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Adiyaman Training Hospital, Adiyaman; Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5302-8953","authenticated-orcid":false,"given":"Naz\u0131m","family":"Ekin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Health Sciences, Diyabakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8321-4829","authenticated-orcid":false,"given":"Medeni","family":"Arpa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Recep Tayyip Erdogan University Schoool of Medicine, Rize, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2137-7934","authenticated-orcid":false,"given":"Kendal","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Deparment of Gastroenterology, Dicle University School of Medicine, Diyarbakir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5966","published-online":{"date-parts":[[2022]]},"container-title":["Hepatology Forum"],"original-title":[],"link":[{"URL":"https:\/\/file.paplino.com\/hepatologyforum\/pdfs\/1663749466-en.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/hepatologyforum.org\/storage\/upload\/pdfs\/1663749466-en.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:33:35Z","timestamp":1793144015000},"score":1,"resource":{"primary":{"URL":"https:\/\/hepatologyforum.org\/articles\/HF-33541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.14744\/hf.2022.2022.0016","relation":{},"ISSN":["1307-5888","2757-7392"],"issn-type":[{"value":"1307-5888","type":"print"},{"value":"2757-7392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}