{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:32:05Z","timestamp":1793147525159,"version":"4.5.0"},"reference-count":0,"publisher":"Kare Publishing","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Forum"],"abstract":"<jats:p>Background and Aim: In chronic hepatitis B infection, antiviral therapy significantly reduces the incidence of complications. This study aimed to present real-life 12-month effectiveness and safety data for TAF.\r\nMaterials and Methods: This Pythagoras Retrospective Cohort Study in-cluded patients from 14 centers in Turkiye. The study presents 12-month results of 480 patients treated with TAF as initial therapy or after switching from another antiviral drug.\r\nResults: The study shows treatment of about 78.1% patients with at least one antiviral agent (90.6% tenofovir disoproxil [TDF]). The rate of unde-tectable HBV DNA increased in both treatment-experienced and naive pa-tients. In TDF-experienced patients, the rate of alanine transaminase (ALT) normalization increased slightly (1.6%) within 12 months, but the change was not statistically significant (p=0.766). Younger age, low albumin, and high body mass index and cholesterol were identified as risk factors for abnormal ALT after 12 months, but no linear relationship was detected. In TDF-experienced patients, renal and bone function indicators showed sig-nificant improvement three months after the transition to TAF and remained stable for 12 months. \r\nConclusion: Real-life data demonstrated effective virological and bio-chemical responses with TAF therapy. After switching to TAF treat-ment, gains in kidney and bone functions were achieved in the early period<\/jats:p>","DOI":"10.14744\/hf.2022.2022.0043","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T06:15:27Z","timestamp":1684390527000},"page":"61-68","source":"Crossref","is-referenced-by-count":2,"title":["First year real life experience with tenofovir alafenamide fumarate: The pythagorean cohort"],"prefix":"10.14744","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4245-1534","authenticated-orcid":false,"given":"Omer","family":"Karasahin","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Erzurum Training and Research Hospital, Erzurum, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5136-9148","authenticated-orcid":false,"given":"Irem","family":"Akdemir Kalkan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara University School of Medicine, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7045-1462","authenticated-orcid":false,"given":"Tuba","family":"Dal","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Yildirim Beyazit University School of Medicine, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2915-4666","authenticated-orcid":false,"given":"Sibel","family":"Altunisik Toplu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Inonu University School of Medicine, Malatya, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9415-147X","authenticated-orcid":false,"given":"Murat","family":"Harputluoglu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Inonu University School of Medicine, Malatya, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0994-4465","authenticated-orcid":false,"given":"Ayse Ozlem","family":"Mete","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Gaziantep University School of Medicine, Gaziantep, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-559X","authenticated-orcid":false,"given":"Suheyla","family":"Komur","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Cukurova University School of Medicine, Adana, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8646-2203","authenticated-orcid":false,"given":"Figen","family":"Sarigul","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Antalya Training and Research Hospital, Antalya, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3006-4112","authenticated-orcid":false,"given":"Yesim","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Gazi University School of Medicine, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8512-5894","authenticated-orcid":false,"given":"Fatih","family":"Esmer","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Sanliurfa Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2602-5826","authenticated-orcid":false,"given":"Ozlem","family":"Kandemir","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Mersin University School of Medicine, Mersin, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0587-0104","authenticated-orcid":false,"given":"Selcuk","family":"Nazik","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Sutcu Imam University School of Medicine, Kahramanmaras, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7551-6728","authenticated-orcid":false,"given":"Dilara","family":"Inan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Akdeniz University School of Medicine, Antalya, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-4598","authenticated-orcid":false,"given":"Fethiye","family":"Akgul","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Batman Training and Research Hospital, Batman, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9912-7340","authenticated-orcid":false,"given":"Safak","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Gazi Yasargil Training and Research Hospital, Diyarbakir16Department of Gastroenterology, Turkiye; Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9723-4510","authenticated-orcid":false,"given":"Nurettin","family":"Tunc","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Turkiye; Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-774X","authenticated-orcid":false,"given":"Yasar","family":"Bayindir","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Inonu University School of Medicine, Malatya, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3722-4660","authenticated-orcid":false,"given":"Safak","family":"Ozer Balin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Firat University School of Medicine, Elazig, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5728-058X","authenticated-orcid":false,"given":"Yesim","family":"Tasova","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Cukurova University School of Medicine, Adana, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0760-5681","authenticated-orcid":false,"given":"Fesih","family":"Aktar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dicle University School of Medicine, Diyarbakir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3383-7830","authenticated-orcid":false,"given":"Meryem Merve","family":"Oner","sequence":"additional","affiliation":[{"name":"Department of Public Health, Istanbul University School of Medicine, Istanbul, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3145-4059","authenticated-orcid":false,"given":"Merve","family":"Ayhan","sequence":"additional","affiliation":[{"name":"Freelance Pharmacist, Batman, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2419-3436","authenticated-orcid":false,"given":"Yakup","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Dicle University School of Medicine, Diyarbakir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5876-2241","authenticated-orcid":false,"given":"Mustafa Kemal","family":"Celen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Dicle University School of Medicine, Diyarbakir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5966","published-online":{"date-parts":[[2023]]},"container-title":["Hepatology Forum"],"original-title":[],"link":[{"URL":"https:\/\/file.paplino.com\/hepatologyforum\/pdfs\/1684399387-en.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/hepatologyforum.org\/storage\/upload\/pdfs\/1684399387-en.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:33:01Z","timestamp":1793143981000},"score":1,"resource":{"primary":{"URL":"https:\/\/hepatologyforum.org\/articles\/HF-53394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.14744\/hf.2022.2022.0043","relation":{},"ISSN":["1307-5888","2757-7392"],"issn-type":[{"value":"1307-5888","type":"print"},{"value":"2757-7392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}