{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:32:15Z","timestamp":1793147535276,"version":"4.5.0"},"reference-count":0,"publisher":"Kare Publishing","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Forum"],"abstract":"<jats:p>Background and Aim: The aims of the present study were to evaluate the real-life efficacy and tolerability of glecaprevir (GLE)\/pibrentasvir (PIB) in the treatment of patients with chronic hepatitis C (CHC).\r\nMaterials and Methods: Between May 2019 and May 2022, 686 patients with CHC, treated with GLE\/PIB combination from 21 participating centers in Turkiye, were enrolled in the study.\r\nResults: All patients were Caucasian, and their median age was 56 years. At the start of GLE\/PIB treatment, the median serum Hepatitis C virus RNA and serum alanine amino transaminase (ALT) levels were 6.74 log10 IU\/mL and 47 U\/L, respectively. Fifty-three percent of the patients were infected with genotype 1b, followed by genotype 3 (17%). Diabetes was the more common concomitant disease. The sustained virological response (SVR12) was 91.4% with intent-to-treat analysis and 98.5% with per proto-col analysis. The SVR12 rates were statistically significant differences be-tween the patients who were i.v. drug users and non-user (88.0% vs. 98.8%,p=0.025). From the baseline to SVR12, the serum ALT levels and Model for End-Stage Liver Disease score were significantly improved (p<\/jats:p>","DOI":"10.14744\/hf.2023.2023.0001","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:58:47Z","timestamp":1792144727000},"page":"92-96","source":"Crossref","is-referenced-by-count":0,"title":["The efficacy and tolerability of glecaprevir\/pibrentasvir treatment in a real-world chronic hepatitis C patients cohort"],"prefix":"10.14744","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1404-7515","authenticated-orcid":false,"given":"Serkan","family":"Yaras","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Mersin University, Mersin, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-5179","authenticated-orcid":false,"given":"Mehmet","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0823-3215","authenticated-orcid":false,"given":"Sezgin","family":"Barutcu","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Faculty of Medicine Internal, Gaziantep University, Gaziantep, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4386-9297","authenticated-orcid":false,"given":"Abdullah Emre","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Memorial Bahcelievler Hospital, Istanbul, 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Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4624-2542","authenticated-orcid":false,"given":"Meral","family":"Akdogan Kayhan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Health Sciences, Clinic of Gastroenterology, Ankara City Hospital, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8413-5353","authenticated-orcid":false,"given":"Sezgin","family":"Vatansever","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Katip Celebi University, Ataturk Training and Research Hospital, \u0130zmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1899-5846","authenticated-orcid":false,"given":"Haydar","family":"Adanir","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Akdeniz University, Antalya, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3939-3089","authenticated-orcid":false,"given":"Nilay","family":"Danis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1171-213X","authenticated-orcid":false,"given":"Serkan","family":"Duman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Internal Medicine, Toros State Hospital, Mersin, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-1965","authenticated-orcid":false,"given":"Ilker","family":"Turan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine Ege University, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8024-781X","authenticated-orcid":false,"given":"Derya","family":"Ari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Health Sciences, Clinic of Gastroenterology, Ankara City Hospital, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4228-1213","authenticated-orcid":false,"given":"Sukran","family":"Kose","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7875-0627","authenticated-orcid":false,"given":"Huseyin","family":"Alkim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sisli Etfal Education and Research Hospital, Istanbul, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9415-147X","authenticated-orcid":false,"given":"Muhsin Murat","family":"Harputluoglu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Inonu University, Malatya, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2901-7044","authenticated-orcid":false,"given":"Feyza","family":"Dilber","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine Marmara University, Istanbul, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2080-7528","authenticated-orcid":false,"given":"Murat","family":"Akyildiz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine Koc University, Istanbul, 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Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1876-2586","authenticated-orcid":false,"given":"Ayse","family":"Kefeli","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Tokat Gaziosmanpasa University, Gaziantep, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5663-0683","authenticated-orcid":false,"given":"Hale","family":"Gokcan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Ankara University, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6905-4494","authenticated-orcid":false,"given":"Ufuk","family":"Avcioglu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, On Dokuz May\u0131s University, Samsun, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1075-7499","authenticated-orcid":false,"given":"Talat","family":"Ayyildiz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, On Dokuz May\u0131s University, Samsun, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6704-4716","authenticated-orcid":false,"given":"Orhan","family":"Sezgin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Mersin University, Mersin, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9217-948X","authenticated-orcid":false,"given":"Mesut","family":"Akarsu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Dokuz Eyl\u0131l, Izmir, 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