{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:32:05Z","timestamp":1793147525565,"version":"4.5.0"},"reference-count":0,"publisher":"Kare Publishing","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Forum"],"abstract":"<jats:p>Background and Aim: This study investigated the risk of the development of primary biliary cholangitis (PBC) in individuals who were incidentally identified as having positive antimitochondrial antibodies (AMA)-M2.\r\nMaterials and Methods: We retrospectively reviewed extractable nuclear antibody (ENA) panel test results to identify the incidental AMA-M2-positive patients. Patients who filled the diagnostic criteria for PBC were excluded. AMA-M2-positive patients were further evaluated by physical examination, liver biochemistry, liver ultrasonography, and transient elas-tography (TE) and were also closely followed.\r\nResults: We included 48 (n=45, 93% female) individuals with a median age of 49 (range: 20\u201369) years. The median follow-up duration was 27 months (range: 9\u201342) after the detection of AMA-M2. Thirty-three (69%) patients had concomitant autoimmune\/inflammatory disorders. Twenty-eight (58%) individuals showed seropositivity for ANA, and 21 had (43%) positive AMA. Fifteen (31%) patients developed typical PBC according to the international PBC diagnostic criteria during the follow-up, and five of them (18%) had significant fibrosis (\u22658.2 kPA) by TE at the time of PBC diagnosis.\r\nConclusion: Two-thirds of the incidental AMA-M2-positive patients devel-oped typical features of PBC after a median 27-month follow-up. Our re-sults suggest that AMA-M2 patients should be closely followed up to detect the late development of PBC.<\/jats:p>","DOI":"10.14744\/hf.2023.2023.0016","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T06:15:27Z","timestamp":1684390527000},"page":"69-73","source":"Crossref","is-referenced-by-count":5,"title":["The risk of development of primary biliary cholangitis among incidental antimitochondrial M2 antibody-positive patients"],"prefix":"10.14744","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1539-501X","authenticated-orcid":false,"given":"Ilkay","family":"Ergenc","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Marmara University, Istanbul, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4471-799X","authenticated-orcid":false,"given":"Busra","family":"Gozaydinoglu","sequence":"additional","affiliation":[{"name":"School of Medicine, Marmara University,, Istanbul, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6304-5554","authenticated-orcid":false,"given":"Caglayan","family":"Keklikkiran","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Rize Training and Research Hospital, Recep Tayyip Erdogan University; Rize, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4518-5283","authenticated-orcid":false,"given":"Yusuf","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Marmara University, Istanbul, Turkiye; Institute of Gastroenterology, Marmara University, Istanbul, Turkiye; Department of Gastroenterology, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5966","published-online":{"date-parts":[[2023]]},"container-title":["Hepatology Forum"],"original-title":[],"link":[{"URL":"https:\/\/file.paplino.com\/hepatologyforum\/pdfs\/1684400454-en.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/hepatologyforum.org\/storage\/upload\/pdfs\/1684400454-en.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:33:01Z","timestamp":1793143981000},"score":1,"resource":{"primary":{"URL":"https:\/\/hepatologyforum.org\/articles\/HF-18639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.14744\/hf.2023.2023.0016","relation":{},"ISSN":["1307-5888","2757-7392"],"issn-type":[{"value":"1307-5888","type":"print"},{"value":"2757-7392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}