{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:33:16Z","timestamp":1793143996648,"version":"4.5.0"},"reference-count":0,"publisher":"Kare Publishing","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Forum"],"abstract":"<jats:p>Background and Aim: It is reported that miRNAs play an important role in hepatocellular carcinogenesis and may serve as non-invasive biomarkers for hepatocellular carcinoma (HCC). MiR-4510 and miR-146b-5p expres-sion levels have been found to be associated with HCC. However, their associations with hepatitis B virus (HBV)-related HCC (HBV-HCC) are yet to be explored. We aimed to assess the predictive value of expression levels of serum miR-4510 and miR-146b-5p in patients with HBV-HCC and performed bioinformatics analyses based on the miRNA expression profile.\r\nMaterials and Methods: This cross-sectional study used the serum of 16 patients with Chronic Hepatitis B (CHB), 15 hepatitis B virus-related cirrhosis (HBV-cirrhosis), 15 HBV-HCC, and 16 healthy subjects. The total RNA was isolated from serum, and the expression of miRNAs was measured by qRT-PCR, calculated using the 2-\u0394\u0394Ct methods. MIENTURNET was used to predict miRNA-target gene interactions. The Network Analyst was used to build protein-protein interactions.\r\nResults: There was a significant difference in miR-146b-5p between study groups (p=0.009). MiR-146b-5p expression was found to be significantly reduced in HBV-HCC compared to the HBV-cirrhosis group and healthy controls (p=0.005 and p=0.006, respectively).\r\nConclusion: The serum miR-146b-5p levels might be a promising tool to be used as a non-invasive diagnostic biomarker for HCC. Our findings shed light on potential biomarkers for the diagnosis of HBV-HCC in terms of selected miRNAs. The target pathways of miR-146b-5p identified by our insilico analysis to reveal the functional mechanism are \u201cMAPK signaling pathways\u201d and \u201cPathways in cancer.\u201d<\/jats:p>","DOI":"10.14744\/hf.2023.2023.0054","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T08:02:30Z","timestamp":1705478550000},"page":"106-112","source":"Crossref","is-referenced-by-count":2,"title":["The preliminary data of gene expressions and bioinformatics analysis of miR-146b-5p and miR-4510 in the Turkish population in HBV-related hepatocellular carcinoma"],"prefix":"10.14744","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5956-9774","authenticated-orcid":false,"given":"Duygu Bircan","family":"Kadioglu","sequence":"first","affiliation":[{"name":"Department of Medical Biology, School of Medicine, Marmara University, Istanbul, Turkiye; Institute of Health Sciences, Marmara University, Istanbul, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0004-2740","authenticated-orcid":false,"given":"Coskun","family":"Ozer Demirtas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Marmara University, Istanbul, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0522-9432","authenticated-orcid":false,"given":"Dilek","family":"Pirim","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology & Genetics, Faculty of Arts and Sciences, Bursa Uludag University, Bursa, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2901-7044","authenticated-orcid":false,"given":"Feyza","family":"Dilber","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Marmara University, Istanbul, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8126-2413","authenticated-orcid":false,"given":"Fatih","family":"Eren","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, School of Medicine, Marmara University, Istanbul, Turkiye; Department of Medical Biology, School of Medicine, Recep Tayyip Erdo\u011fan University ,\u00a0 Rize, Turkiye; Institute of Gastroenterology, Marmara University, Istanbul, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5966","published-online":{"date-parts":[[2024]]},"container-title":["Hepatology Forum"],"original-title":[],"link":[{"URL":"https:\/\/file.paplino.com\/hepatologyforum\/pdfs\/1719999710-en.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/hepatologyforum.org\/storage\/upload\/pdfs\/1719999710-en.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:23:26Z","timestamp":1793143406000},"score":1,"resource":{"primary":{"URL":"https:\/\/hepatologyforum.org\/articles\/HF-34176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.14744\/hf.2023.2023.0054","relation":{},"ISSN":["1307-5888","2757-7392"],"issn-type":[{"value":"1307-5888","type":"print"},{"value":"2757-7392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}