{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:33:15Z","timestamp":1793143995239,"version":"4.5.0"},"reference-count":0,"publisher":"Kare Publishing","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Forum"],"abstract":"<jats:p>Background and Aim: The primary aim of this study was to investigate the concordance of Transient Elastography FibroScan\u00ae (FS) measurements, Fibrosis-4 (FIB-4), and the Aspartate Aminotransferase to Platelet Ratio Index (APRI) scores with each other and with liver biopsies in predicting histological fibrosis.\r\nMaterials and Methods: In this single-center, cross-sectional, retrospec-tive collected data cohort study spanning seven consecutive years, simultaneous FS measurements, FIB-4, and APRI scores of 778 patients with different diagnoses who had undergone liver biopsy were evaluated.\r\nResults: A total of 417 (53.6%) of the patients were female. The median age was 51 years. The diagnoses were HBV (n=228), metabolic dysfunction-associated steatotic liver disease (MASLD) (n=185), HCV (n=58), cryptogenic (n=53), primary biliary cholangitis (n=40), autoimmune hepatitis (AIH) (n=28), overlap syndrome (OS) (n=23), multiple diag-noses (n=42), and other diagnoses (n=83). All three methods showed a strong correlation with histological fibrosis, and FS demonstrated a statistically significantly superior relationship compared to FIB-4 and APRI. In AIH and OS, FIB-4 and APRI scores do not show a consistent increase with histological stage; however, FS does. In MASLD, all three methods correlate with histologic stage, but FS measurements appear significantly superior.\r\nConclusion: Although FIB-4, APRI, and FS correlate well with histological fibrosis, especially in MASLD, evaluation with FS, if available, should be preferred. In the evaluation of fibrosis in AIH and OS, laboratory-based indicators should be avoided.<\/jats:p>","DOI":"10.14744\/hf.2024.2024.0024","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T01:39:41Z","timestamp":1732844381000},"page":"16-21","source":"Crossref","is-referenced-by-count":4,"title":["Performance of non-invasive fibrosis markers in biopsy-proven liver disorders"],"prefix":"10.14744","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3939-3089","authenticated-orcid":false,"given":"Nilay","family":"Danis","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6002-4819","authenticated-orcid":false,"given":"Fulya","family":"Gunsar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1837-6498","authenticated-orcid":false,"given":"Funda","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Medical Pathology, Ege University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8100-6978","authenticated-orcid":false,"given":"Deniz","family":"Nart","sequence":"additional","affiliation":[{"name":"Department of Medical Pathology, Ege University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-1965","authenticated-orcid":false,"given":"Ilker","family":"Turan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4974-7944","authenticated-orcid":false,"given":"Zeki","family":"Karasu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2040-7524","authenticated-orcid":false,"given":"Galip","family":"Ersoz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7020-5816","authenticated-orcid":false,"given":"Ulus Salih","family":"Akarca","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6960-4043","authenticated-orcid":false,"given":"Omer","family":"Ozutemiz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5966","published-online":{"date-parts":[[2025]]},"container-title":["Hepatology Forum"],"original-title":[],"link":[{"URL":"https:\/\/file.paplino.com\/hepatologyforum\/pdfs\/1736517434-en.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/hepatologyforum.org\/storage\/upload\/pdfs\/1732862040-en.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:22:53Z","timestamp":1793143373000},"score":1,"resource":{"primary":{"URL":"https:\/\/hepatologyforum.org\/articles\/HF-68303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.14744\/hf.2024.2024.0024","relation":{},"ISSN":["1307-5888","2757-7392"],"issn-type":[{"value":"1307-5888","type":"print"},{"value":"2757-7392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}