{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:33:08Z","timestamp":1793143988262,"version":"4.5.0"},"reference-count":0,"publisher":"Kare Publishing","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Forum"],"abstract":"<jats:p>Background and Aim: Early detection, accurate evaluation, and proper follow-up of fibrosis in chronic liver disease are crucial for improving disease prognosis. Indirect biochemical fibrosis tests, such as the AST-to-Platelet Ratio Index (APRI) and Fibrosis-4 (FIB-4) score, have been developed, incorporating parameters like AST, ALT, and platelet count. However, the influence of factors such as Helicobacter pylori (H. pylori) on fibrosis tests such as APRI and FIB-4 remains unclear, and this study aimed to evaluate its impact.\r\nMaterials and Methods: This study included 190 patients (aged \u226518 years) who underwent gastric and liver biopsies at a tertiary center between 2006 and 2021. Patients were categorized into three groups based on liver histo-pathological findings: mild (F0-1), moderate (F2-3), and advanced (F4-6) fibrosis. Additionally, patients were grouped based on H. pylori presence as determined by gastric histopathology. Demographic, clinical, laboratory, imaging, and histopathological characteristics were analyzed and compared between groups.\r\nResults: Among the 190 patients, H. pylori was detected in 135 (71%) and was absent in 55 (29%). No significant differences were observed between H. pylori-positive and -negative groups in terms of AST, ALT, platelet count, INR, FIB-4, or APRI scores. For APRI, significant differences were found between mild-moderate and mild-advanced fibrosis groups (p0.05). For FIB-4, significant differences were observed across all fibrosis groups (p<\/jats:p>","DOI":"10.14744\/hf.2024.2024.0067","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T09:12:48Z","timestamp":1751879568000},"page":"105-110","source":"Crossref","is-referenced-by-count":0,"title":["Does Helicobacter pylori infection affect indirect hepatic fibrosis tests?"],"prefix":"10.14744","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7065-9730","authenticated-orcid":false,"given":"Ali Cagatay","family":"Bozkina","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7859-4094","authenticated-orcid":false,"given":"Goksel","family":"Bengi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7496-9493","authenticated-orcid":false,"given":"Suleyman","family":"Dolu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6183-6848","authenticated-orcid":false,"given":"Anil","family":"Aysal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dokuz Eylul University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-639X","authenticated-orcid":false,"given":"Mujde","family":"Soyturk","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5863-3298","authenticated-orcid":false,"given":"Ender Berat","family":"Ellidokuz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2699-021X","authenticated-orcid":false,"given":"Omer Selahattin","family":"Topalak","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8734-2518","authenticated-orcid":false,"given":"Hale","family":"Akp\u0131nar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9217-948X","authenticated-orcid":false,"given":"Mesut","family":"Akarsu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dokuz Eylul University School of Medicine, Izmir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5966","published-online":{"date-parts":[[2025]]},"container-title":["Hepatology Forum"],"original-title":[],"link":[{"URL":"https:\/\/file.paplino.com\/hepatologyforum\/pdfs\/1751890621-en.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/hepatologyforum.org\/storage\/upload\/pdfs\/1751890621-en.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:22:32Z","timestamp":1793143352000},"score":1,"resource":{"primary":{"URL":"https:\/\/hepatologyforum.org\/articles\/HF-45088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.14744\/hf.2024.2024.0067","relation":{},"ISSN":["1307-5888","2757-7392"],"issn-type":[{"value":"1307-5888","type":"print"},{"value":"2757-7392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}