{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:11:49Z","timestamp":1791515509117,"version":"4.3.4"},"reference-count":0,"publisher":"Kare Publishing","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Forum"],"abstract":"<jats:p>Background and Aim: The World Health Organization has a goal to eliminate the hepatitis C virus (HCV) by 2030. To achieve this, effective screening for HCV is essential. We evaluated the utility of the ELECSYS\u00ae HCV Duo immunoassay (Duo assay) for HCV screening.\r\nMaterials and Methods: This single-center retrospective study included 184 HCV patients from 2014 to 2017. We measured HCV antibody (Duo\/Ab) and HCV core antigen (Duo\/cAg) using the Duo assay in HCV RNA-positive samples obtained before DAA therapy. We compared Duo\/cAg positivity rates according to host and viral factors. We also performed logistic regression analysis and decision tree analysis to identify independent factors and profiles for Duo\/cAg false-negative results, respectively.\r\nResults: Duo\/Ab positivity rates were 100%, and Duo\/cAg positivity rates were 78% in all subjects. Duo\/cAg positivity rates were 40.0%, 78.6%, and 92.9% at HCV RNA levels \u22644.9, 5.0\u20135.9, and \u22656.0 log IU\/mL, respectively (p30 U\/L, and HCV genotype. In multivariate analysis, the HCV RNA level (Unit \u22121.0 log IU\/mL, OR 5.49, CI 3.12\u201310.56, p<\/jats:p>","DOI":"10.14744\/hf.2025.27743","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T19:03:36Z","timestamp":1779131016000},"page":"118-124","source":"Crossref","is-referenced-by-count":1,"title":["The usefulness of a simultaneous immunoassay for hepatitis C virus antigen-antibody using the ELECSYS HCV Duo assay"],"prefix":"10.14744","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-7973","authenticated-orcid":false,"given":"Keisuke","family":"Amano","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan; Fukuoka Consulting & Support Center for Liver Diseases, Kurume University Hospital, Kurume, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3229-3149","authenticated-orcid":false,"given":"Tomoya","family":"Sano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan; Fukuoka Consulting & Support Center for Liver Diseases, Kurume University Hospital, Kurume, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4106-6527","authenticated-orcid":false,"given":"Tatsuya","family":"Ide","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan; Fukuoka Consulting & Support Center for Liver Diseases, Kurume University Hospital, Kurume, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-1224","authenticated-orcid":false,"given":"Dan","family":"Nakano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3375-1372","authenticated-orcid":false,"given":"Shigemune","family":"Bekki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5264-237X","authenticated-orcid":false,"given":"Teruko","family":"Arinaga-Hino","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan; School of Medical Technology, Kurume University, Kurume, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7064-4325","authenticated-orcid":false,"given":"Takumi","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5966","published-online":{"date-parts":[[2026]]},"container-title":["Hepatology Forum"],"original-title":[],"link":[{"URL":"https:\/\/file.paplino.com\/hepatologyforum\/pdfs\/1779128579-en.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/hepatologyforum.org\/storage\/upload\/pdfs\/1779128579-en.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:46:54Z","timestamp":1791222414000},"score":1,"resource":{"primary":{"URL":"https:\/\/hepatologyforum.org\/articles\/HF-27743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.14744\/hf.2025.27743","relation":{},"ISSN":["1307-5888","2757-7392"],"issn-type":[{"value":"1307-5888","type":"print"},{"value":"2757-7392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}