{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:59:55Z","timestamp":1791223195083,"version":"4.1.0"},"reference-count":0,"publisher":"Kare Publishing","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Forum"],"abstract":"<jats:p>Background and Aim: Hepatic encephalopathy is an important cause of morbidity in cirrhosis patients. The presence of spontaneous portosystemic shunts (SPSS) is associated with an increased risk of recurrent\/refractory hepatic encephalopathy (HE). Embolization of SPSS has been shown to improve HE symptoms, but it may worsen portal hypertension and related complications. The aim of this study was to determine the efficacy of SPSS embolization for recurrent\/refractory HE.\r\nMaterials and Methods: Five databases were screened to identify studies assessing the efficacy of SPSS embolization for HE. The random-effects model was used to calculate the pooled rates, and I2% values were used to assess heterogeneity.\r\nResults: Twenty-one studies met the inclusion criteria, comprising a total of 331 patients with recurrent or refractory HE despite medical management. The etiology of cirrhosis included ethanol abuse, chronic viral hepatitis, MASH, and others. Following embolization, 82% of patients had HE-related clinical improvement, and 71% of patients became free from HE-related hospitalization. The mean difference in pre- and post-embolization serum ammonia levels was 104 [77-130], p<\/jats:p>","DOI":"10.14744\/hf.2025.59487","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T19:03:36Z","timestamp":1779131016000},"page":"91-100","source":"Crossref","is-referenced-by-count":0,"title":["Embolization of spontaneous portosystemic shunts for refractory hepatic encephalopathy in cirrhosis patients: A meta-analysis"],"prefix":"10.14744","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5481-5464","authenticated-orcid":false,"given":"Parth","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Saint Joseph Hospital, Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8809-5005","authenticated-orcid":false,"given":"Mohamad","family":"Ebrahim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Saint Joseph Hospital, Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1476-2009","authenticated-orcid":false,"given":"Eli","family":"Zaher","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Saint Joseph Hospital, Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7745-7277","authenticated-orcid":false,"given":"Himsikhar","family":"Khataniar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Allegheny General Hospital, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4247-2412","authenticated-orcid":false,"given":"Priyadarshini","family":"Loganathan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Texas Health Science Center San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3214-6285","authenticated-orcid":false,"given":"Douglas","family":"G. Adler","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Center for Advanced Therapeutic Endoscopy at Porter Adventist Hospital, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5966","published-online":{"date-parts":[[2026]]},"container-title":["Hepatology Forum"],"original-title":[],"link":[{"URL":"https:\/\/file.paplino.com\/hepatologyforum\/pdfs\/1779128331-en.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/hepatologyforum.org\/storage\/upload\/pdfs\/1779128331-en.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:46:53Z","timestamp":1791222413000},"score":1,"resource":{"primary":{"URL":"https:\/\/hepatologyforum.org\/articles\/HF-59487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.14744\/hf.2025.59487","relation":{},"ISSN":["1307-5888","2757-7392"],"issn-type":[{"value":"1307-5888","type":"print"},{"value":"2757-7392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}