{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:59:12Z","timestamp":1791223152320,"version":"4.1.0"},"reference-count":0,"publisher":"Kare Publishing","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Forum"],"abstract":"<jats:p>Background and Aim: Despite advances in non-invasive methods, liver biopsy remains essential for diagnosis, prognosis, and treatment planning, and this study aimed to evaluate trends in its indications and pathological findings.\r\nMaterials and Methods: A total of 1533 adult liver biopsies at a tertiary referral hospital (2000\u20132022) were retrospectively reviewed for indications and diagnoses.\r\nResults: The annual number of liver biopsies performed remained stable over the last two decades (730 vs. 803; p=0.06). The mean patient age was 43\u00b115 years, with 52% being female. The leading indications were abnormal liver function tests (53.4%), fibrosis\/cirrhosis (40.9%), treatment follow-up (2.7%), hepatomegaly (1.6%), and fever of unknown origin (0.9%). Between 2000\u20132011 and 2012\u20132022, the indications for liver biopsy changed significantly: biopsies for fibrosis\/cirrhosis increased, whereas those for evaluation of treatment response and disease monitoring and for hepatomegaly decreased (p=0.01, p<\/jats:p>","DOI":"10.14744\/hf.2026.96331","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T07:29:48Z","timestamp":1785396588000},"page":"262-268","source":"Crossref","is-referenced-by-count":0,"title":["Shifts in liver biopsy indications and histopathological diagnoses: A report from a tertiary care center in T\u00fcrkiye"],"prefix":"10.14744","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6453-8957","authenticated-orcid":false,"given":"Yunus Emre","family":"Dalkilic","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Hacettepe University, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7349-8415","authenticated-orcid":false,"given":"Yavuz Emre","family":"Parlar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, School of Medicine, Hacettepe University, Ankara, Turkiye of Internal Medicine, Division of Gastroenterology, School of Medicine, Hacettepe University, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7037-5233","authenticated-orcid":false,"given":"Cem","family":"Simsek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, School of Medicine, Hacettepe University, Ankara, Turkiye of Internal Medicine, Division of Gastroenterology, School of Medicine, Hacettepe University, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3942-2572","authenticated-orcid":false,"given":"Zehranur","family":"Kiki","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Hacettepe University, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1750-8789","authenticated-orcid":false,"given":"Osman","family":"Dag","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Medicine, Hacettepe University, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7637-8745","authenticated-orcid":false,"given":"Cenk","family":"Sokmensuer","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Hacettepe University, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0901-9192","authenticated-orcid":false,"given":"Hatice Yasemin","family":"Balaban","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, School of Medicine, Hacettepe University, Ankara, Turkiye of Internal Medicine, Division of Gastroenterology, School of Medicine, Hacettepe University, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5966","published-online":{"date-parts":[[2026]]},"container-title":["Hepatology Forum"],"original-title":[],"link":[{"URL":"https:\/\/file.paplino.com\/hepatologyforum\/pdfs\/1785335849-en.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/hepatologyforum.org\/articles\/HF-96331\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:45:01Z","timestamp":1791222301000},"score":1,"resource":{"primary":{"URL":"https:\/\/hepatologyforum.org\/articles\/HF-96331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.14744\/hf.2026.96331","relation":{},"ISSN":["1307-5888","2757-7392"],"issn-type":[{"value":"1307-5888","type":"print"},{"value":"2757-7392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}