{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:33:51Z","timestamp":1792424031658,"version":"4.5.0"},"reference-count":51,"publisher":"XMLink","issue":"3","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["btrt.org"],"crossmark-restriction":false},"short-container-title":["Brain Tumor Res Treat"],"published-print":{"date-parts":[[2025]]},"DOI":"10.14791\/btrt.2025.0017","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T05:43:39Z","timestamp":1754027019000},"page":"73","update-policy":"https:\/\/doi.org\/10.14791\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Therapeutic Targeting of DNA Damage Response Pathways in\n                    <i>TP53<\/i>\n                    - and\n                    <i>ATM<\/i>\n                    -Mutated Tumors"],"prefix":"10.14791","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5047-3493","authenticated-orcid":false,"given":"Ye Jee","family":"Shim","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea."},{"name":"Division of Pediatric Hematology\/Oncology, Kyungpook National University Children\u2019s Hospital, Daegu, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18617","reference":[{"key":"10.14791\/btrt.2025.0017_ref1","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"10.14791\/btrt.2025.0017_ref2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41568-022-00535-5","volume":"23","author":"Groelly","year":"2023","journal-title":"Nat Rev Cancer"},{"key":"10.14791\/btrt.2025.0017_ref3","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/s41419-022-05408-1","volume":"13","author":"Chen","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.14791\/btrt.2025.0017_ref4","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1158\/1535-7163.MCT-15-0945","volume":"15","author":"Choi","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"10.14791\/btrt.2025.0017_ref5","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.1038\/s41467-024-49316-8","volume":"15","author":"Laverty","year":"2024","journal-title":"Nat Commun"},{"key":"10.14791\/btrt.2025.0017_ref6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41573-024-01060-w","volume":"24","author":"Drew","year":"2025","journal-title":"Nat Rev Drug Discov"},{"key":"10.14791\/btrt.2025.0017_ref7","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.tips.2016.06.006","volume":"37","author":"Matheson","year":"2016","journal-title":"Trends Pharmacol Sci"},{"key":"10.14791\/btrt.2025.0017_ref8","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.radonc.2017.09.043","volume":"126","author":"Qiu","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.14791\/btrt.2025.0017_ref9","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1126\/science.aam7344","volume":"355","author":"Lord","year":"2017","journal-title":"Science"},{"key":"10.14791\/btrt.2025.0017_ref10","doi-asserted-by":"crossref","first-page":"1073797","DOI":"10.3389\/fmolb.2022.1073797","volume":"9","author":"Hunia","year":"2022","journal-title":"Front Mol Biosci"},{"key":"10.14791\/btrt.2025.0017_ref11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrm3546","volume":"14","author":"Shiloh","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.14791\/btrt.2025.0017_ref12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/cancers9050041","volume":"9","author":"Rundle","year":"2017","journal-title":"Cancers (Basel)"},{"key":"10.14791\/btrt.2025.0017_ref13","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nrm.2017.67","volume":"18","author":"Saldivar","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.14791\/btrt.2025.0017_ref14","doi-asserted-by":"crossref","first-page":"104710","DOI":"10.1016\/j.critrevonc.2025.104710","volume":"211","author":"Thangaretnam","year":"2025","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.14791\/btrt.2025.0017_ref15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11523-025-01136-6","volume":"20","author":"Ampolini","year":"2025","journal-title":"Target Oncol"},{"key":"10.14791\/btrt.2025.0017_ref16","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1021\/acs.jmedchem.3c02277","volume":"67","author":"Pike","year":"2024","journal-title":"J Med Chem"},{"key":"10.14791\/btrt.2025.0017_ref17","doi-asserted-by":"crossref","first-page":"eaat1719","DOI":"10.1126\/sciadv.aat1719","volume":"4","author":"Durant","year":"2018","journal-title":"Sci Adv"},{"key":"10.14791\/btrt.2025.0017_ref18","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1093\/neuonc\/noad064","volume":"25","author":"Xie","year":"2023","journal-title":"Neuro Oncol"},{"key":"10.14791\/btrt.2025.0017_ref19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1158\/1535-7163.MCT-18-1394","volume":"19","author":"Riches","year":"2020","journal-title":"Mol Cancer Ther"},{"key":"10.14791\/btrt.2025.0017_ref20","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1186\/s12885-022-10084-7","volume":"22","author":"Davis","year":"2022","journal-title":"BMC Cancer"},{"key":"10.14791\/btrt.2025.0017_ref21","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1158\/1535-7163.MCT-22-0685","volume":"22","author":"Turchick","year":"2023","journal-title":"Mol Cancer Ther"},{"key":"10.14791\/btrt.2025.0017_ref22","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2017.05.015","volume":"66","author":"Blackford","year":"2017","journal-title":"Mol Cell"},{"key":"10.14791\/btrt.2025.0017_ref23","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S1470-2045(20)30180-7","volume":"21","author":"Konstantinopoulos","year":"2020","journal-title":"Lancet Oncol"},{"key":"10.14791\/btrt.2025.0017_ref24","doi-asserted-by":"crossref","first-page":"e175369","DOI":"10.1172\/JCI175369","volume":"134","author":"Dillon","year":"2024","journal-title":"J Clin Invest"},{"key":"10.14791\/btrt.2025.0017_ref25","doi-asserted-by":"crossref","first-page":"e000340","DOI":"10.1136\/jitc-2019-000340","volume":"8","author":"Sheng","year":"2020","journal-title":"J Immunother Cancer"},{"key":"10.14791\/btrt.2025.0017_ref26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.annonc.2021.10.009","volume":"33","author":"Kim","year":"2022","journal-title":"Ann Oncol"},{"key":"10.14791\/btrt.2025.0017_ref27","doi-asserted-by":"crossref","first-page":"e005041","DOI":"10.1136\/jitc-2022-005041","volume":"10","author":"Kwon","year":"2022","journal-title":"J Immunother Cancer"},{"key":"10.14791\/btrt.2025.0017_ref28","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1158\/1078-0432.CCR-23-1696","volume":"29","author":"Ring","year":"2023","journal-title":"Clin Cancer Res"},{"key":"10.14791\/btrt.2025.0017_ref29","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1158\/2159-8290.CD-20-0868","volume":"11","author":"Yap","year":"2021","journal-title":"Cancer Discov"},{"key":"10.14791\/btrt.2025.0017_ref30","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1021\/acs.jmedchem.3c01917","volume":"67","author":"Black","year":"2024","journal-title":"J Med Chem"},{"key":"10.14791\/btrt.2025.0017_ref31","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1158\/1078-0432.CCR-23-1763","volume":"30","author":"Pili\u00e9","year":"2024","journal-title":"Clin Cancer Res"},{"key":"10.14791\/btrt.2025.0017_ref32","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1158\/1078-0432.CCR-23-2409","volume":"30","author":"Yap","year":"2024","journal-title":"Clin Cancer Res"},{"key":"10.14791\/btrt.2025.0017_ref33","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1158\/1078-0432.CCR-17-3347","volume":"24","author":"Hong","year":"2018","journal-title":"Clin Cancer Res"},{"key":"10.14791\/btrt.2025.0017_ref34","doi-asserted-by":"crossref","first-page":"e29065","DOI":"10.1002\/pbc.29065","volume":"68","author":"Cash","year":"2021","journal-title":"Pediatr Blood Cancer"},{"key":"10.14791\/btrt.2025.0017_ref35","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00280-014-2380-5","volume":"73","author":"Sausville","year":"2014","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.14791\/btrt.2025.0017_ref36","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s10637-019-00873-6","volume":"38","author":"Bendell","year":"2020","journal-title":"Invest New Drugs"},{"key":"10.14791\/btrt.2025.0017_ref37","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1200\/JCO.2014.57.5027","volume":"33","author":"Daud","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.14791\/btrt.2025.0017_ref38","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1200\/JCO.19.00730","volume":"37","author":"Cuneo","year":"2019","journal-title":"J Clin Oncol"},{"key":"10.14791\/btrt.2025.0017_ref39","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1158\/1078-0432.CCR-21-0158","volume":"28","author":"Moore","year":"2022","journal-title":"Clin Cancer Res"},{"key":"10.14791\/btrt.2025.0017_ref40","first-page":"vdac073","volume":"4","author":"Mueller","year":"2022","journal-title":"Neurooncol Adv"},{"key":"10.14791\/btrt.2025.0017_ref41","doi-asserted-by":"crossref","first-page":"13004","DOI":"10.1021\/acs.jmedchem.1c01121","volume":"64","author":"Huang","year":"2021","journal-title":"J Med Chem"},{"key":"10.14791\/btrt.2025.0017_ref42","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.molonc.2011.07.001","volume":"5","author":"Helleday","year":"2011","journal-title":"Mol Oncol"},{"key":"10.14791\/btrt.2025.0017_ref43","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.1158\/1078-0432.CCR-24-1402","volume":"30","author":"Hussain","year":"2024","journal-title":"Clin Cancer Res"},{"key":"10.14791\/btrt.2025.0017_ref44","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41416-019-0565-8","volume":"121","author":"Jette","year":"2019","journal-title":"Br J Cancer"},{"key":"10.14791\/btrt.2025.0017_ref45","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/bjh.14793","volume":"182","author":"Pratt","year":"2018","journal-title":"Br J Haematol"},{"key":"10.14791\/btrt.2025.0017_ref46","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/S1470-2045(19)30396-1","volume":"20","author":"Friedlander","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.14791\/btrt.2025.0017_ref47","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1056\/NEJMoa1909707","volume":"381","author":"Coleman","year":"2019","journal-title":"N Engl J Med"},{"key":"10.14791\/btrt.2025.0017_ref48","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3389\/fonc.2015.00169","volume":"5","author":"VanderWeele","year":"2015","journal-title":"Front Oncol"},{"key":"10.14791\/btrt.2025.0017_ref49","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1001\/jamaoncol.2022.5218","volume":"9","author":"Schram","year":"2023","journal-title":"JAMA Oncol"},{"key":"10.14791\/btrt.2025.0017_ref50","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1007\/s12282-024-01603-4","volume":"31","author":"Telli","year":"2024","journal-title":"Breast Cancer"},{"key":"10.14791\/btrt.2025.0017_ref51","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1200\/JCO.19.02404","volume":"38","author":"Yap","year":"2020","journal-title":"J Clin Oncol"}],"container-title":["Brain Tumor Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/btrt.org\/pdf\/10.14791\/btrt.2025.0017","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/btrt.org\/DOIx.php?id=10.14791\/btrt.2025.0017","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/btrt.org\/DOIx.php?id=10.14791\/btrt.2025.0017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T05:49:31Z","timestamp":1754027371000},"score":1,"resource":{"primary":{"URL":"https:\/\/btrt.org\/DOIx.php?id=10.14791\/btrt.2025.0017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.14791\/btrt.2025.0017","relation":{},"ISSN":["2288-2405","2288-2413"],"issn-type":[{"value":"2288-2405","type":"print"},{"value":"2288-2413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"2025-06-12","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-13","name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-15","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-30","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"Copyright \u00a9 2025 The Korean Brain Tumor Society, The Korean Society for Neuro-Oncology, and The Korean Society for Pediatric Neuro-Oncology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}