{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:59:00Z","timestamp":1793980740272,"version":"4.8.0"},"reference-count":38,"publisher":"The Korean Movement Disorder Society","issue":"4","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-jmd.org"],"crossmark-restriction":true},"short-container-title":["JMD"],"published-print":{"date-parts":[[2024,10,31]]},"abstract":"<jats:p>Objective  Orthostatic hypotension (OH) is one of the most common autonomic dysfunctions in Parkinson\u2019s disease (PD) patients. However, many patients with OH are asymptomatic. Conversely, orthostatic dizziness (OD) is not always associated with OH. We investigated the effects of positional changes on cerebral perfusion in patients with PD and OH.Methods  We enrolled 42 patients, comprising 31 PD patients and 11 healthy controls. All the subjects underwent the following clinical assessments: the OH questionnaire, head-up tilt test (HUTT) with transcranial Doppler (TCD), near-infrared spectroscopy, measurement of the change in oxygenated hemoglobin (\u0394Hboxy) during the squat-to-stand test (SST), measurement of the time derivative of total hemoglobin (DHbtot), and time taken to reach the peak (peak time [PT]) of DHbtot after restanding.Results  The mean flow velocity change (\u0394MFV) in the TCD during the HUTT failed to differentiate between the PD-OH(+) and PD-OH(-) groups. The change in oxygenated hemoglobin \u0394Hboxy was greater in the PD-OH(+) group, which persisted for 9 min until the end of the HUTT only in the left hemisphere. During SST, PT was significantly delayed in the left hemisphere in PD-OH(+) patients.Conclusion  Although TCD demonstrated no significant difference in \u0394MFV, the parameters measured by near-infrared spectroscopy, such as \u0394Hboxy during HUTT and PT during the SST, significantly increased \u0394Hboxy or delayed PT in the left hemisphere of PD-OH(+). Positional changes have a detrimental effect on cerebral hemodynamics in patients with PD and OH, especially in the left hemisphere.<\/jats:p>","DOI":"10.14802\/jmd.24104","type":"journal-article","created":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T23:21:16Z","timestamp":1725837676000},"page":"408-415","update-policy":"https:\/\/doi.org\/10.14802\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Positional Changes on Cerebral Perfusion in Parkinson\u2019s Disease Patients With Orthostatic Hypotension"],"prefix":"10.14802","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2485-6105","authenticated-orcid":true,"given":"Jae Young","family":"Joo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-6118","authenticated-orcid":true,"given":"Dallah","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9538-9634","authenticated-orcid":true,"given":"Jae-Myoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4157-492X","authenticated-orcid":true,"given":"Chaewon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7315-6298","authenticated-orcid":true,"given":"Tae-Beom","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5803","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(16)30079-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.805887"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.811698"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.927009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/1179546820953415"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12236"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/s1353-8020(03)00069-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2010.06.016"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00724"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2016.03.004"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.11.019"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"ref13","first-page":"2129","volume-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results","author":"Goetz","year":"2008"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/bf02260863"},{"key":"ref15","first-page":"189","volume-title":"\u201cMini-mental state\u201d. 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