{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:49:30Z","timestamp":1786121370330,"version":"build-2736575974"},"reference-count":46,"publisher":"The Korean Movement Disorder Society","issue":"3","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00245506"],"award-info":[{"award-number":["RS-2023-00245506"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-jmd.org"],"crossmark-restriction":true},"short-container-title":["JMD"],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:p>Objective Vestibulo-ocular reflex (VOR) impairment has been reported in Parkinson\u2019s disease (PD). However, its clinical implications, particularly with respect to cognition, remain unclear. We investigated canal-specific VOR changes and their associations with cognitive function, motor symptoms, gaits, and dopamine transporter (DAT) uptake in de novo PD patients.Methods We prospectively enrolled 127 patients with de novo PD who underwent video head-impulse tests (video-HITs), comprehensive neuropsychological assessments, gait analysis, and &lt;sup&gt;18&lt;\/sup&gt;F-N-(3-fluoropropyl)-2\u03b2-carbon ethoxy-3\u03b2-(4-iodophenyl) nortropane positron emission tomography. Associations between VOR gains and the clinical characteristics of PD were evaluated using general linear models adjusted for age, sex, and education level. Cognitive analyses were performed after the patients were stratified into PD with normal cognition (PD-NC) and PD with mild cognitive impairment (PD-MCI) groups. Partial correlation analyses were performed to assess the relationships between VOR gains and regional DAT uptake.Results Decreased VOR gain in at least one canal was observed in 22 patients (17.32%). Horizontal canal (HC) gain was positively associated with the Korean version of Montreal Cognitive Assessment score (&lt;i&gt;p&lt;\/i&gt;=0.040), and anterior canal (AC) gain was negatively associated with the base of support (&lt;i&gt;p&lt;\/i&gt;=0.018). The patterns of association between VOR gains and neuropsychological measures differed between the PD-NC and PD-MCI groups. In addition, VOR\u2013cognition relationships were canal-specific: HC gain was positively related to visuospatial function, whereas AC and posterior canal gains were negatively related to language and frontal\u2013executive functions. DAT uptake in the locus coeruleus was positively correlated with HC gain (&lt;i&gt;p&lt;\/i&gt;=0.020).Conclusion VOR integrity is associated with cognitive and gait function in patients with PD. Video-HITs may serve as potential biomarkers for disease monitoring in PD patients.<\/jats:p>","DOI":"10.14802\/jmd.25230","type":"journal-article","created":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T23:47:11Z","timestamp":1771804031000},"page":"275-283","update-policy":"https:\/\/doi.org\/10.14802\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between the Vestibulo-Ocular Reflex and Cognitive Function in de novo Parkinson\u2019s Disease"],"prefix":"10.14802","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2714-7494","authenticated-orcid":true,"given":"Mincheol","family":"Park","sequence":"first","affiliation":[{"name":"Department of Neurology, Chung-Ang University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6180-8551","authenticated-orcid":true,"given":"Hyun Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Korea University Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1285-4658","authenticated-orcid":true,"given":"Chan-Nyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Korea University Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6526-614X","authenticated-orcid":true,"given":"Kun-Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Korea University Medical Center, Seoul, Korea"},{"name":"Geriatric Health Clinic and Research Institute, Korea University Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8660-7759","authenticated-orcid":true,"given":"Sun-Uk","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Korea University Medical Center, Seoul, Korea"},{"name":"Neurotology and Neuro-Ophthalmology Laboratory, Korea University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7215-375X","authenticated-orcid":true,"given":"Kyoungwon","family":"Baik","sequence":"additional","affiliation":[{"name":"Department of Neurology, Korea University Medical Center, Seoul, 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