{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:06:20Z","timestamp":1787022380172,"version":"build-2736575974"},"reference-count":44,"publisher":"The Korean Movement Disorder Society","issue":"1","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS-2023-KH134527"],"award-info":[{"award-number":["RS-2023-KH134527"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS-2023-00266948"],"award-info":[{"award-number":["RS-2023-00266948"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS-2025-02273192"],"award-info":[{"award-number":["RS-2025-02273192"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-jmd.org"],"crossmark-restriction":true},"short-container-title":["JMD"],"published-print":{"date-parts":[[2026,1,31]]},"abstract":"<jats:p>Objective This study aims to investigate the clinical relevance of occipital hypoperfusion in patients with Parkinson\u2019s disease (PD) with respect to clinical phenotype and the risk of dementia conversion.Methods We enrolled 349 patients with newly diagnosed PD and 48 healthy controls who underwent dual-phase &lt;sup&gt;18&lt;\/sup&gt;F-N-(3-fluoropropyl)-2\u03b2-carboxymethoxy-3\u03b2-(4-iodophenyl) nortropane (&lt;sup&gt;18&lt;\/sup&gt;F-FP-CIT) positron emission tomography (PET). Patients with PD were classified into three groups based on posterior cortical perfusion patterns on early-phase &lt;sup&gt;18&lt;\/sup&gt;F-FP-CIT PET images: PD with preserved posterior cortical perfusion (&lt;i&gt;n&lt;\/i&gt;=186), PD with parieto-temporal hypoperfusion (&lt;i&gt;n&lt;\/i&gt;=84), and PD with parieto-temporo-occipital hypoperfusion (&lt;i&gt;n&lt;\/i&gt;=79). Baseline clinical features and dementia conversion risk were compared across PD groups.Results Patients with preserved posterior cortical perfusion were younger than those in the other PD groups. Compared with the other groups, the parieto-temporo-occipital hypoperfusion group tended to have lower Cross-Cultural Smell Identification Test scores, a higher prevalence of rapid eye movement sleep behavior disorder, higher Unified PD Rating Scale motor scores, and more severe reductions in striatal dopamine transporter availability. The risk of dementia conversion was lower in patients with preserved posterior cortical perfusion than in those with posterior cortical hypoperfusion. However, the risk of dementia conversion did not differ between the parieto-temporal and parieto-temporo-occipital hypoperfusion groups.Conclusion Additional occipital hypoperfusion was not associated with an imminent risk of dementia conversion in patients with PD with posterior cortical hypoperfusion. Nonetheless, occipital involvement may serve as an indicator of the diffuse malignant subtype of PD.<\/jats:p>","DOI":"10.14802\/jmd.25231","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T05:36:28Z","timestamp":1762493788000},"page":"58-66","update-policy":"https:\/\/doi.org\/10.14802\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Additional Occipital Involvement in Parkinson\u2019s Disease With Posterior Cortical Hypoperfusion"],"prefix":"10.14802","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0208-5189","authenticated-orcid":true,"given":"Chan Wook","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2128-3524","authenticated-orcid":true,"given":"Su 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