{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:48:58Z","timestamp":1786121338579,"version":"build-2736575974"},"reference-count":31,"publisher":"The Korean Movement Disorder Society","issue":"3","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["2024ER100202"],"award-info":[{"award-number":["2024ER100202"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1I1A1A01050492"],"award-info":[{"award-number":["2021R1I1A1A01050492"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00452428"],"award-info":[{"award-number":["RS-2024-00452428"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1D1A1B06028086"],"award-info":[{"award-number":["2017R1D1A1B06028086"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2021-NR065151"],"award-info":[{"award-number":["RS-2021-NR065151"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["RS-2017-NR027859"],"award-info":[{"award-number":["RS-2017-NR027859"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-jmd.org"],"crossmark-restriction":true},"short-container-title":["JMD"],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:p>Objective The thyroid gland receives sympathetic innervation. &lt;sup&gt;123&lt;\/sup&gt;I-meta-iodobenzylguanidine (&lt;sup&gt;123&lt;\/sup&gt;I-MIBG) is a noradrenaline analog taken up by adrenergic nerve terminals. Although thyroid uptake can be detected on &lt;sup&gt;123&lt;\/sup&gt;I-MIBG scintigraphy, its quantitative value is poorly understood. This study examined the clinical relevance of thyroid &lt;sup&gt;123&lt;\/sup&gt;I-MIBG uptake in Parkinson\u2019s disease (PD).Methods A total of 233 de novo patients were enrolled in a longitudinal cohort and underwent &lt;sup&gt;123&lt;\/sup&gt;I-MIBG scintigraphy. Early and late heart-to-mediastinum ratios (HMRs) and early thyroid-to-mediastinum ratios (TMRs) were calculated. Baseline TMRs were estimated using a mixed model after verifying the empirical linear decline over time. Observed and model-implied uptake ratios were analyzed in relation to adrenergic blood pressure (BP) control, motor and nonmotor burdens, and quality of life (QoL). Baseline thyroid uptake was further assessed for its influence on longitudinal disease progression.Results Patients were assessed for early PD (mean age, 68.7\u00b18.7 years; median disease duration, 1.0 years). The mean follow-up was 57.3\u00b122.1 months. A lower baseline HMR correlated with greater changes in orthostatic BP, greater autonomic symptom burden, and worse motor and nonmotor functions and QoL. Overall, the TMR was not significantly correlated; however, it was associated with a greater occurrence of supine hypertension, orthostatic hypotension, and nondipper or nocturnal hypertension. Thyroid uptake did not influence longitudinal changes in motor, nonmotor, cognitive, or QoL measures, although higher uptake tended to be associated with slower cognitive decline and better QoL.Conclusion Thyroid &lt;sup&gt;123&lt;\/sup&gt;I-MIBG uptake did not predict disease progression but may indicate early blood pressure dysregulation and could reflect nonmotor vulnerability in PD patients.<\/jats:p>","DOI":"10.14802\/jmd.26046","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T23:33:06Z","timestamp":1778023986000},"page":"295-303","update-policy":"https:\/\/doi.org\/10.14802\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Significance of Thyroid 123I- Meta-Iodobenzylguanidine Uptake in Parkinson\u2019s Disease"],"prefix":"10.14802","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7988-0228","authenticated-orcid":true,"given":"Sang-Won","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3390-4607","authenticated-orcid":true,"given":"Dong-Woo","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1566-6265","authenticated-orcid":true,"given":"Yoonsang","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-1373","authenticated-orcid":true,"given":"Seunggyun","family":"Ha","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8087-7977","authenticated-orcid":true,"given":"Joong-Seok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5803","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-015-0142-3","type":"journal-article"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-39-4-713","type":"journal-article"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-013-0204-z","type":"journal-article"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/bf02984609","type":"journal-article"},{"key":"ref5","first-page":"55","type":"journal-article","volume-title":"<sup>123<\/sup>I-metaiodobenzylguanidine myocardial scintigraphy in Lewy body-related disorders: a literature review","author":"Chung","year":"2015"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.25137","type":"journal-article"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(23)00404-0","type":"journal-article"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.01.001","type":"journal-article"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-021-00217-3","type":"journal-article"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-015-0168-6","type":"journal-article"},{"key":"ref11","first-page":"499","type":"journal-article","volume-title":"Profile for brain disease research infrastructure for data gathering and exploration (BRIDGE) 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Parkinson\u2019s disease-autonomic","author":"Kim","year":"2017"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-018-0529-8","type":"journal-article"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8375-x","type":"journal-article"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25834","type":"journal-article"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25170","type":"journal-article"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.14179","type":"journal-article"},{"key":"ref26","first-page":"639","type":"journal-article","volume-title":"Orthostatic hypotension in Parkinson disease: how much you fall or how low you go?","author":"Palma","year":"2015"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13652","type":"journal-article"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.11.001","type":"journal-article"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13206","type":"journal-article"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-011-0598-5","type":"journal-article"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3390\/ph17121563","type":"journal-article"}],"container-title":["Journal of Movement 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