{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:16:47Z","timestamp":1792059407754,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AR-41802"],"award-info":[{"award-number":["AR-41802"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.14814\/phy2.12081","type":"journal-article","created":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T02:18:11Z","timestamp":1405649891000},"page":"e12081","source":"Crossref","is-referenced-by-count":32,"title":["Eccentric contractions disrupt FKBP12 content in mouse skeletal muscle"],"prefix":"10.14814","volume":"2","author":[{"given":"Cory W.","family":"Baumann","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Health; Muscle Biology Laboratory; Georgia State University; Atlanta Georgia 30302"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell G.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health; Muscle Biology Laboratory; Georgia State University; Atlanta Georgia 30302"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Gahlot","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health; Muscle Biology Laboratory; Georgia State University; Atlanta Georgia 30302"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7303-3167","authenticated-orcid":false,"given":"Christopher P.","family":"Ingalls","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health; Muscle Biology Laboratory; Georgia State University; Atlanta Georgia 30302"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,17]]},"reference":[{"key":"10.14814\/phy2.12081-BIB0001|phy212081-cit-0001","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0006-3495(97)78654-5","article-title":"Subconductance states in single-channel activity of skeletal muscle ryanodine receptors after removal of FKBP12","volume":"72","author":"Ahern","year":"1997","journal-title":"Biophys. J."},{"key":"10.14814\/phy2.12081-BIB0002|phy212081-cit-0002","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1113\/jphysiol.2005.091694","article-title":"Mechanisms of stretch-induced muscle damage in normal and dystrophic muscle: role of ionic changes","volume":"567","author":"Allen","year":"2005","journal-title":"J. Physiol."},{"key":"10.14814\/phy2.12081-BIB0003|phy212081-cit-0003","doi-asserted-by":"crossref","first-page":"22600","DOI":"10.1074\/jbc.M205866200","article-title":"FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes","volume":"278","author":"Avila","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.12081-BIB0004|phy212081-cit-0004","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1113\/jphysiol.1995.sp020943","article-title":"Intracellular calcium and force in single mouse muscle fibres following repeated contractions with stretch","volume":"488","author":"Balnave","year":"1995","journal-title":"J. Physiol."},{"key":"10.14814\/phy2.12081-BIB0005|phy212081-cit-0005","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1073\/pnas.0711074105","article-title":"Remodeling of ryanodine receptor complex causes \u201cleaky\u201d channels: a molecular mechanism for decreased exercise capacity","volume":"105","author":"Bellinger","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.14814\/phy2.12081-BIB0006|phy212081-cit-0006","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0092-8674(94)90214-3","article-title":"Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein","volume":"77","author":"Brillantes","year":"1994","journal-title":"Cell"},{"key":"10.14814\/phy2.12081-BIB0007|phy212081-cit-0007","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.tcm.2004.06.003","article-title":"Regulation of ryanodine receptors by FK506 binding proteins","volume":"14","author":"Chelu","year":"2004","journal-title":"Trends Cardiovasc. Med."},{"issue":"Suppl","key":"10.14814\/phy2.12081-BIB0008|phy212081-cit-0008","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1097\/00002060-200211001-00007","article-title":"Exercise-induced muscle damage in humans","volume":"81","author":"Clarkson","year":"2002","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"10.14814\/phy2.12081-BIB0009|phy212081-cit-0009","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/mus.23655","article-title":"Nitric oxide synthase inhibition increases immediate force loss after eccentric contractions","volume":"47","author":"Corona","year":"2013","journal-title":"Muscle Nerve"},{"key":"10.14814\/phy2.12081-BIB0010|phy212081-cit-0010","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1152\/japplphysiol.90926.2008","article-title":"Eccentric contractions do not induce rhabdomyolysis in malignant hyperthermia susceptible mice","volume":"105","author":"Corona","year":"2008a","journal-title":"J. Appl. Physiol."},{"key":"10.14814\/phy2.12081-BIB0011|phy212081-cit-0011","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1152\/japplphysiol.01145.2007","article-title":"FKBP12 deficiency reduces strength deficits after eccentric contraction-induced muscle injury","volume":"105","author":"Corona","year":"2008b","journal-title":"J. Appl. Physiol."},{"key":"10.14814\/phy2.12081-BIB0012|phy212081-cit-0012","doi-asserted-by":"crossref","first-page":"C365","DOI":"10.1152\/ajpcell.00365.2009","article-title":"Junctophilin damage contributes to early strength deficits and EC coupling failure after eccentric contractions","volume":"298","author":"Corona","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.14814\/phy2.12081-BIB0013|phy212081-cit-0013","doi-asserted-by":"crossref","first-page":"e49326","DOI":"10.1371\/journal.pone.0049326","article-title":"Intense resistance exercise induces early and transient increases in ryanodine receptor 1 phosphorylation in human skeletal muscle","volume":"7","author":"Gehlert","year":"2012","journal-title":"PLoS One"},{"key":"10.14814\/phy2.12081-BIB0014|phy212081-cit-0014","doi-asserted-by":"crossref","first-page":"20857","DOI":"10.1016\/S0021-9258(19)36767-5","article-title":"Calcium activated neutral protease effects upon skeletal muscle sarcoplasmic reticulum protein structure and calcium release","volume":"267","author":"Gilchrist","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.12081-BIB0015|phy212081-cit-0015","doi-asserted-by":"crossref","first-page":"43717","DOI":"10.1074\/jbc.M111.292755","article-title":"Junctophilin 1 and 2 proteins interact with the L-type Ca2+ channel dihydropyridine receptors (DHPRs) in skeletal muscle","volume":"286","author":"Golini","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.12081-BIB0016|phy212081-cit-0016","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1023\/A:1005496708505","article-title":"Caffeine and excitation-contraction coupling in skeletal muscle: a stimulating story","volume":"20","author":"Herrmann-Frank","year":"1999","journal-title":"J. Muscle Res. Cell. Motil."},{"key":"10.14814\/phy2.12081-BIB0017|phy212081-cit-0017","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1529\/biophysj.105.076570","article-title":"Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes","volume":"90","author":"Hirata","year":"2006","journal-title":"Biophys. J."},{"key":"10.14814\/phy2.12081-BIB0018|phy212081-cit-0018","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/mus.24077","article-title":"Lengthening our perspective: morphological, cellular, and molecular responses to eccentric exercise","volume":"49","author":"Hyldahl","year":"2013","journal-title":"Muscle Nerve"},{"key":"10.14814\/phy2.12081-BIB0019|phy212081-cit-0019","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1023\/A:1005368831198","article-title":"Dissociation of force production from MHC and actin contents in muscles injured by eccentric contractions","volume":"19","author":"Ingalls","year":"1998a","journal-title":"J. Muscle Res. Cell Motil."},{"key":"10.14814\/phy2.12081-BIB0020|phy212081-cit-0020","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1152\/jappl.1998.85.1.58","article-title":"E-C coupling failure in mouse EDL muscle after in vivo eccentric contractions","volume":"85","author":"Ingalls","year":"1998b","journal-title":"J. Appl. Physiol."},{"key":"10.14814\/phy2.12081-BIB0021|phy212081-cit-0021","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1152\/japplphysiol.00084.2003","article-title":"Dihydropyridine and ryanodine receptor binding after eccentric contractions in mouse skeletal muscle","volume":"96","author":"Ingalls","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"10.14814\/phy2.12081-BIB0022|phy212081-cit-0022","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1083\/jcb.200105040","article-title":"Deficiency of triad junction and contraction in mutant skeletal muscle lacking junctophilin type 1","volume":"154","author":"Ito","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.14814\/phy2.12081-BIB0023|phy212081-cit-0023","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0014-5793(02)03042-9","article-title":"Deficiency of triad formation in developing skeletal muscle cells lacking junctophilin type 1","volume":"524","author":"Komazaki","year":"2002","journal-title":"FEBS Lett."},{"key":"10.14814\/phy2.12081-BIB0024|phy212081-cit-0024","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1016\/j.febslet.2010.03.005","article-title":"Ryanodine receptor studies using genetically engineered mice","volume":"584","author":"Kushnir","year":"2010","journal-title":"FEBS Lett."},{"key":"10.14814\/phy2.12081-BIB0025|phy212081-cit-0025","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1469-7793.2001.0715h.x","article-title":"Different Ca2+ releasing action of caffeine and depolarisation in skeletal muscle fibres of the rat","volume":"531","author":"Lamb","year":"2001","journal-title":"J. Physiol."},{"key":"10.14814\/phy2.12081-BIB0026|phy212081-cit-0026","doi-asserted-by":"crossref","first-page":"a003996","DOI":"10.1101\/cshperspect.a003996","article-title":"Ryanodine receptors: structure, expression, molecular details, and function in calcium release","volume":"2","author":"Lanner","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.14814\/phy2.12081-BIB0027|phy212081-cit-0027","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1152\/jappl.1994.76.4.1445","article-title":"Eccentric contraction-induced injury of mouse soleus muscle: effect of varying [Ca2+]o","volume":"76","author":"Lowe","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"10.14814\/phy2.12081-BIB0028|phy212081-cit-0028","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1152\/jappl.1995.79.4.1260","article-title":"Muscle function and protein metabolism after initiation of eccentric contraction-induced injury","volume":"79","author":"Lowe","year":"1995","journal-title":"J. Appl. Physiol."},{"key":"10.14814\/phy2.12081-BIB0029|phy212081-cit-0029","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0143-4160(97)90022-1","article-title":"Quantitative measurement of resting skeletal muscle [Ca2+]i following acute and long-term downhill running exercise in mice","volume":"22","author":"Lynch","year":"1997","journal-title":"Cell Calcium"},{"key":"10.14814\/phy2.12081-BIB0030|phy212081-cit-0030","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1113\/jphysiol.2012.243279","article-title":"Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle","volume":"591","author":"Murphy","year":"2013","journal-title":"J. Physiol."},{"key":"10.14814\/phy2.12081-BIB0031|phy212081-cit-0031","doi-asserted-by":"crossref","first-page":"R1490","DOI":"10.1152\/ajpregu.00032.2003","article-title":"Importance of satellite cells in the strength recovery after eccentric contraction-induced muscle injury","volume":"285","author":"Rathbone","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.14814\/phy2.12081-BIB0032|phy212081-cit-0032","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1242\/jeb.01329","article-title":"Low-frequency fatigue, post-tetanic potentiation and their interaction at different muscle lengths following eccentric exercise","volume":"208","author":"Rijkelijkhuizen","year":"2005","journal-title":"J. Exp. Biol."},{"key":"10.14814\/phy2.12081-BIB0033|phy212081-cit-0033","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s002329900312","article-title":"Identification, characterization and partial purification of a thiol-protease which cleaves specifically the skeletal muscle ryanodine receptor\/Ca2+ release channel","volume":"161","author":"Shevchenko","year":"1998","journal-title":"J. Membr. Biol."},{"key":"10.14814\/phy2.12081-BIB0034|phy212081-cit-0034","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1469-7793.2001.0571a.x","article-title":"Eccentric exercise-induced morphological changes in the membrane systems involved in excitation-contraction coupling in rat skeletal muscle","volume":"533","author":"Takekura","year":"2001","journal-title":"J. Physiol."},{"key":"10.14814\/phy2.12081-BIB0035|phy212081-cit-0035","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1096\/fj.04-1587fje","article-title":"Altered excitation-contraction coupling with skeletal muscle specific FKBP12 deficiency","volume":"18","author":"Tang","year":"2004","journal-title":"FASEB J."},{"key":"10.14814\/phy2.12081-BIB0036|phy212081-cit-0036","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1113\/jphysiol.1993.sp019783","article-title":"Excitation failure in eccentric contraction-induced injury of mouse soleus muscle","volume":"468","author":"Warren","year":"1993","journal-title":"J. Physiol."},{"key":"10.14814\/phy2.12081-BIB0037|phy212081-cit-0037","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1152\/jappl.1994.77.3.1421","article-title":"Eccentric contraction-induced injury in normal and hindlimb-suspended mouse soleus and EDL muscles","volume":"77","author":"Warren","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"10.14814\/phy2.12081-BIB0038|phy212081-cit-0038","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/BF00319121","article-title":"Redistribution of cell membrane probes following contraction-induced injury of mouse soleus muscle","volume":"282","author":"Warren","year":"1995","journal-title":"Cell Tissue Res."},{"key":"10.14814\/phy2.12081-BIB0039|phy212081-cit-0039","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1469-7793.1999.609ac.x","article-title":"Uncoupling of in vivo torque production from EMG in muscles injured by eccentric contractions","volume":"515","author":"Warren","year":"1999","journal-title":"J. Physiol."},{"key":"10.14814\/phy2.12081-BIB0040|phy212081-cit-0040","doi-asserted-by":"crossref","first-page":"R1122","DOI":"10.1152\/ajpregu.00671.2001","article-title":"Temperature dependency of force loss and Ca2+ homeostasis in mouse EDL muscle after eccentric contractions","volume":"282","author":"Warren","year":"2002a","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.14814\/phy2.12081-BIB0041|phy212081-cit-0041","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2519\/jospt.2002.32.2.58","article-title":"What mechanisms contribute to the strength loss that occurs during and in the recovery from skeletal muscle injury?","volume":"32","author":"Warren","year":"2002b","journal-title":"J. Orthop. Sports Phys. Ther."},{"key":"10.14814\/phy2.12081-BIB0042|phy212081-cit-0042","doi-asserted-by":"crossref","first-page":"25051","DOI":"10.1074\/jbc.272.40.25051","article-title":"Functional interactions between cytoplasmic domains of the skeletal muscle Ca2+ release channel","volume":"272","author":"Wu","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.12081-BIB0043|phy212081-cit-0043","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1113\/jphysiol.2001.013839","article-title":"Development of T-tubular vacuoles in eccentrically damaged mouse muscle fibres","volume":"540","author":"Yeung","year":"2002","journal-title":"J. Physiol."}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.12081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.14814\/phy2.12081\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T13:16:09Z","timestamp":1649682969000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.14814\/phy2.12081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"URL":"https:\/\/doi.org\/10.14814\/phy2.12081","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}