{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:44:34Z","timestamp":1787676274568,"version":"build-2784847793"},"reference-count":47,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T00:00:00Z","timestamp":1468281600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004046","name":"Karen Elise Jensens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Helen and Ejnar Bj\u00f8rnow Foundation"},{"name":"AP Moller Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.14814\/phy2.12865","type":"journal-article","created":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T01:03:54Z","timestamp":1468371834000},"page":"e12865","source":"Crossref","is-referenced-by-count":15,"title":["Remote ischemic perconditioning attenuates ischemia\/reperfusion-induced downregulation of AQP2 in rat kidney"],"prefix":"10.14814","volume":"4","author":[{"given":"Marie Louise V.","family":"Kristensen","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine; Aarhus University; Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper","family":"Kierulf-Lassen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine; Aarhus University; Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Mose","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine; Aarhus University; Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Krag","sequence":"additional","affiliation":[{"name":"Department of Pathology; Aarhus University; Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Birn","sequence":"additional","affiliation":[{"name":"Department of Biomedicine; Aarhus University; Aarhus Denmark"},{"name":"Department of Renal Medicine; Aarhus University; Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene N.","family":"Nejsum","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine; Aarhus University; Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke","family":"N\u00f8rregaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine; Aarhus University; Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,12]]},"reference":[{"key":"10.14814\/phy2.12865-BIB0001|phy212865-cit-0001","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1681\/ASN.2006070756","article-title":"Incidence and outcomes in acute kidney injury: a comprehensive population-based study","volume":"18","author":"Ali","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.12865-BIB0002|phy212865-cit-0002","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1681\/ASN.2013101040","article-title":"Akt Substrate of 160 kD Regulates Na+, K\u00a0+\u00a0-ATPase Trafficking in Response to Energy Depletion and Renal Ischemia","volume":"26","author":"Alves","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.12865-BIB0003|phy212865-cit-0003","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1203\/00006450-200206000-00010","article-title":"Ischemic conditioning prevents Na, K-ATPase dissociation from the cytoskeletal cellular fraction after repeat renal ischemia in rats","volume":"51","author":"Aufricht","year":"2002","journal-title":"Pediatr. Res."},{"key":"10.14814\/phy2.12865-BIB0004|phy212865-cit-0004","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1172\/JCI45161","article-title":"Cellular pathophysiology of ischemic acute kidney injury","volume":"121","author":"Bonventre","year":"2011","journal-title":"J Clin Invest"},{"key":"10.14814\/phy2.12865-BIB0005|phy212865-cit-0005","first-page":"479730","article-title":"Epidemiology of acute kidney injury in the intensive care unit","volume":"2013","author":"Case","year":"2013","journal-title":"Crit Care Res Pract"},{"key":"10.14814\/phy2.12865-BIB0006|phy212865-cit-0006","doi-asserted-by":"crossref","first-page":"F29","DOI":"10.1152\/ajprenal.2000.278.1.F29","article-title":"Localization and regulation of PKA-phosphorylated AQP2 in response to V2-receptor agonist\/antagonist treatment","volume":"278","author":"Christensen","year":"2000","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.14814\/phy2.12865-BIB0007|phy212865-cit-0007","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/ki.2011.379","article-title":"Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis","volume":"81","author":"Coca","year":"2012","journal-title":"Kidney Int."},{"key":"10.14814\/phy2.12865-BIB0008|phy212865-cit-0008","doi-asserted-by":"crossref","first-page":"8984","DOI":"10.1073\/pnas.91.19.8984","article-title":"Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat","volume":"91","author":"DiGiovanni","year":"1994","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.14814\/phy2.12865-BIB0009|phy212865-cit-0009","doi-asserted-by":"crossref","first-page":"F534","DOI":"10.1152\/ajprenal.00083.2008","article-title":"Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression","volume":"295","author":"El-Achkar","year":"2008","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.14814\/phy2.12865-BIB0010|phy212865-cit-0010","doi-asserted-by":"crossref","first-page":"F1066","DOI":"10.1152\/ajprenal.00543.2012","article-title":"Tamm-Horsfall protein translocates to the basolateral domain of thick ascending limbs, interstitium, and circulation during recovery from acute kidney injury","volume":"304","author":"El-Achkar","year":"2013","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.14814\/phy2.12865-BIB0011|phy212865-cit-0011","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1681\/ASN.V1081658","article-title":"Decreased abundance of collecting duct aquaporins in post-ischemic renal failure in rats","volume":"10","author":"Fern\u00e1ndez-Llama","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.12865-BIB0012|phy212865-cit-0012","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/361549a0","article-title":"Cloning and expression of apical membrane water channel of rat kidney collecting tubule","volume":"361","author":"Fushimi","year":"1993","journal-title":"Nature"},{"key":"10.14814\/phy2.12865-BIB0013|phy212865-cit-0013","doi-asserted-by":"crossref","first-page":"14800","DOI":"10.1074\/jbc.272.23.14800","article-title":"Phosphorylation of serine 256 is required for cAMP-dependent regulatory exocytosis of the aquaporin-2 water channel","volume":"272","author":"Fushimi","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.12865-BIB0014|phy212865-cit-0014","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3892\/mmr.2013.1697","article-title":"Crosstalk between dopamine receptors and the Na+\/K\u00a0+\u00a0-ATPase (Review)","volume":"8","author":"Gao","year":"2013","journal-title":"Mol Med Rep"},{"key":"10.14814\/phy2.12865-BIB0015|phy212865-cit-0015","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1681\/ASN.2013070708","article-title":"Remote ischemic preconditioning and renoprotection: from myth to a novel therapeutic option?","volume":"25","author":"Gassanov","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.12865-BIB0016|phy212865-cit-0016","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1161\/01.CIR.94.9.2193","article-title":"Myocardial Protection by Brief Ischemia in Noncardiac Tissue","volume":"94","author":"Gho","year":"1996","journal-title":"Circulation"},{"key":"10.14814\/phy2.12865-BIB0017|phy212865-cit-0017","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1523-1755.2004.00791.x","article-title":"EPO and alpha-MSH prevent ischemia\/reperfusion-induced down-regulation of AQPs and sodium transporters in rat kidney","volume":"66","author":"Gong","year":"2004","journal-title":"Kidney Int."},{"key":"10.14814\/phy2.12865-BIB0018|phy212865-cit-0018","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.3892\/mmr.2014.2641","article-title":"Ischemic postconditioning prevents renal ischemia reperfusion injury through the induction of heat shock proteins in rats","volume":"10","author":"Guo","year":"2014","journal-title":"Mol Med Rep"},{"key":"10.14814\/phy2.12865-BIB0019|phy212865-cit-0019","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ab.2012.10.010","article-title":"Stain-Free technology as a normalization tool in Western blot analysis","volume":"433","author":"G\u00fcrtler","year":"2013","journal-title":"Anal. Biochem."},{"key":"10.14814\/phy2.12865-BIB0020|phy212865-cit-0020","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s11845-014-1227-8","article-title":"Protective effects of three remote ischemic conditioning procedures against renal ischemic\/reperfusion injury in rat kidneys: a comparative study","volume":"184","author":"Jiang","year":"2015","journal-title":"Irish J. Med. Sci."},{"key":"10.14814\/phy2.12865-BIB0021|phy212865-cit-0021","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0005-2736(74)90293-4","article-title":"Purification and characterization of (Na+ plus K+)-ATPase. IV. Estimation of the purity and of the molecular weight and polypeptide content per enzyme unit in preparations from the outer medulla of rabbit kidney","volume":"356","author":"Jorgensen","year":"1974","journal-title":"Biochim. Biophys. Acta"},{"key":"10.14814\/phy2.12865-BIB0022|phy212865-cit-0022","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1152\/physrev.1980.60.3.864","article-title":"Sodium and potassium ion pump in kidney tubules","volume":"60","author":"Jorgensen","year":"1980","journal-title":"Physiol. Rev."},{"key":"10.14814\/phy2.12865-BIB0023|phy212865-cit-0023","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/ki.1985.216","article-title":"Monoclonal antibody to Na, K-ATPase: immunocytochemical localization along nephron segments","volume":"28","author":"Kashgarian","year":"1985","journal-title":"Kidney Int."},{"key":"10.14814\/phy2.12865-BIB0024|phy212865-cit-0024","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000437352","article-title":"Molecular mechanisms of renal ischemic conditioning strategies","volume":"55","author":"Kierulf-Lassen","year":"2015","journal-title":"Eur. Surg. Res."},{"key":"10.14814\/phy2.12865-BIB0025|phy212865-cit-0025","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/ki.1972.97","article-title":"Countercurrent multiplication system without active transport in inner medulla","volume":"2","author":"Kokko","year":"1972","journal-title":"Kidney Int."},{"key":"10.14814\/phy2.12865-BIB0026|phy212865-cit-0026","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.bbagen.2013.12.002","article-title":"Renal aquaporins and water balance disorders","volume":"1840","author":"Kortenoeven","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.14814\/phy2.12865-BIB0027|phy212865-cit-0027","first-page":"F413","article-title":"Reduced abundance of aquaporins in rats with bilateral ischemia-induced acute renal failure: prevention by alpha-MSH","volume":"277","author":"Kwon","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.14814\/phy2.12865-BIB0028|phy212865-cit-0028","doi-asserted-by":"crossref","first-page":"F290","DOI":"10.1152\/ajprenal.00072.2008","article-title":"The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells","volume":"295","author":"Lu","year":"2008","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.14814\/phy2.12865-BIB0029|phy212865-cit-0029","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11010-005-9021-6","article-title":"Evolution of renal function and Na+, K\u00a0+\u00a0-ATPase expression during ischaemia-reperfusion injury in rat kidney","volume":"287","author":"Molinas","year":"2006","journal-title":"Mol. Cell. Biochem."},{"key":"10.14814\/phy2.12865-BIB0030|phy212865-cit-0030","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"key":"10.14814\/phy2.12865-BIB0031|phy212865-cit-0031","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1113\/jphysiol.2004.081463","article-title":"Differential expression of heat shock protein 27 and 70 in renal papillary collecting duct and interstitial cells - implications for urea resistance","volume":"564","author":"Neuhofer","year":"2005","journal-title":"J. Physiol."},{"key":"10.14814\/phy2.12865-BIB0032|phy212865-cit-0032","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1152\/physrev.00024.2001","article-title":"Aquaporins in the kidney: from molecules to medicine","volume":"82","author":"Nielsen","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.14814\/phy2.12865-BIB0033|phy212865-cit-0033","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1046\/j.1440-1681.2000.03378.x","article-title":"Ischaemic preconditioning ameliorates functional disturbance and impaired renal perfusion in rat ischaemia-reperfused kidneys","volume":"27","author":"Ogawa","year":"2000","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.14814\/phy2.12865-BIB0034|phy212865-cit-0034","doi-asserted-by":"crossref","first-page":"F958","DOI":"10.1152\/ajprenal.00469.2012","article-title":"The role of 70-kDa heat shock protein in dDAVP-induced AQP2 trafficking in kidney collecting\u00a0duct cells","volume":"304","author":"Park","year":"2013","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.14814\/phy2.12865-BIB0035|phy212865-cit-0035","article-title":"V3 stain-free workflow for a practical, convenient, and reliable total protein loading control in western blotting","volume":"50948","author":"Posch","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.14814\/phy2.12865-BIB0036|phy212865-cit-0036","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1515\/znc-2002-5-628","article-title":"A quick assay for Na+-K\u00a0+\u00a0-AtPase specific activity","volume":"57","author":"Sarkar","year":"2002","journal-title":"Zeitschrift f\u00fcr Naturforschung C, J Biosci"},{"key":"10.14814\/phy2.12865-BIB0037|phy212865-cit-0037","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25\u00a0years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.14814\/phy2.12865-BIB0038|phy212865-cit-0038","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s004240050399","article-title":"The response of heat shock proteins 25 and 72 to ischaemia in different kidney zones","volume":"434","author":"Schober","year":"1997","journal-title":"Pflugers Arch."},{"key":"10.14814\/phy2.12865-BIB0039|phy212865-cit-0039","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/1440-1681.12044","article-title":"Remote preconditioning reduces oxidative stress, downregulates cyclo-oxygenase-2 expression and attenuates ischaemia-reperfusion-induced acute kidney injury","volume":"40","author":"Sedaghat","year":"2013","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.14814\/phy2.12865-BIB0040|phy212865-cit-0040","first-page":"F414","article-title":"Long-term regulation of four renal aquaporins in rats","volume":"271","author":"Terris","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.14814\/phy2.12865-BIB0041|phy212865-cit-0041","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1046\/j.1523-1755.2002.00360.x","article-title":"Promising effects of ischemic preconditioning in renal transplantation","volume":"61","author":"Torras","year":"2002","journal-title":"Kidney Int."},{"key":"10.14814\/phy2.12865-BIB0042|phy212865-cit-0042","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ki.1978.87","article-title":"Ischemic damage and repair in the rat proximal tubule: differences among the S1, S2, and S3 segments","volume":"14","author":"Venkatachalam","year":"1978","journal-title":"Kidney Int."},{"key":"10.14814\/phy2.12865-BIB0043|phy212865-cit-0043","doi-asserted-by":"crossref","first-page":"F531","DOI":"10.1152\/ajprenal.2001.281.3.F531","article-title":"Immunocytochemical localization of Na-K-ATPase alpha- and gamma-subunits in rat kidney","volume":"281","author":"Wetzel","year":"2001","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.14814\/phy2.12865-BIB0044|phy212865-cit-0044","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s10157-013-0789-5","article-title":"Vasopressin and the regulation of aquaporin-2","volume":"17","author":"Wilson","year":"2013","journal-title":"Clin. Exp. Nephrol."},{"key":"10.14814\/phy2.12865-BIB0045|phy212865-cit-0045","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/00005344-200309000-00014","article-title":"Role of nitric oxide in the renal protective effects of ischemic preconditioning","volume":"42","author":"Yamashita","year":"2003","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.14814\/phy2.12865-BIB0046|phy212865-cit-0046","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1124\/jpet.104.074427","article-title":"Endothelial Nitric Oxide Contributes to the Renal Protective Effects of Ischemic Preconditioning","volume":"312","author":"Yamasowa","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.14814\/phy2.12865-BIB0047|phy212865-cit-0047","first-page":"57","article-title":"Heat shock protein expression is highly sensitive to ischemia-reperfusion injury in rat kidneys","volume":"38","author":"Zhang","year":"2008","journal-title":"Ann. Clin. Lab. Sci."}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.12865","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.14814\/phy2.12865\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T00:58:24Z","timestamp":1656809904000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.14814\/phy2.12865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":47,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2016,7]]}},"URL":"https:\/\/doi.org\/10.14814\/phy2.12865","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]}}}