{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T08:05:33Z","timestamp":1772697933665,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["119513"],"award-info":[{"award-number":["119513"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role of interleukin\u20101 (IL\u20101), a pro\u2010inflammatory cytokine, in parturition is typically noted by changes in its concentrations. Studying the expression of its receptor family, IL\u20101 receptor (IL\u20101R) 1, IL\u20101R2, IL\u20101R accessory protein (IL\u20101RAcP), and its predominantly brain isoform, IL\u20101RAcPb, during late gestation in the uterus in the Long\u2010Evans rat is another. We assessed changes in their mRNA and protein relative abundance in the uterus and compared IL\u20101RAcP and IL\u20101RAcPb mRNA abundance in uterus, cervix, ovaries, placenta, and whole blood of Long\u2010Evans rats during late gestation or in RU486 and progesterone\u2010treated dams using quantitative real\u2010time PCR and western immunoblotting. IL\u20101R1, IL\u20101RAcP, and IL\u20101RAcPb mRNA abundance significantly increased in the uterus at delivery whereas IL\u20101R2 mRNA abundance significantly decreased. IL\u20101R1 protein increased at term and IL\u20101R2 protein decreased at term compared to nonpregnant uteri. IL1\u2010RAcPb mRNA abundance was less than IL\u20101RAcP, but in the lower uterine segment it was the highest of all tissues examined. RU486 stimulated preterm delivery and an increase in IL\u20101R1 mRNA abundance whereas progesterone administration extended pregnancy and suppressed the increase in IL\u20101R1. These data suggest that changes in uterine sensitivity to IL\u20101 occur during late gestation and suggest another level of regulation for the control of delivery. The roles for IL\u20101RAcP and IL\u20101RAcPb need to be determined, but may relate to different intracellular signaling pathways.<\/jats:p>","DOI":"10.14814\/phy2.12866","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T01:33:10Z","timestamp":1469064790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Interleukin (<scp>IL<\/scp>)\u20101 in rat parturition: <scp>IL<\/scp>\u20101 receptors 1 and 2 and accessory proteins abundance in pregnant rat uterus at term \u2013 regulation by progesterone"],"prefix":"10.14814","volume":"4","author":[{"given":"Tomohito","family":"Ishiguro","sequence":"first","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Physiology &amp; Pediatrics University of Alberta Edmonton Canada"},{"name":"Departments of Obstetrics and Gynecology Juntendo University Faculty of Medicine Tokyo Japan"},{"name":"Departments of Obstetrics and Gynecology Koshigaya Municipal Hospital Koshigaya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Takeda","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Physiology &amp; Pediatrics University of Alberta Edmonton Canada"},{"name":"Departments of Obstetrics and Gynecology Juntendo University Faculty of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Fang","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Physiology &amp; Pediatrics University of Alberta Edmonton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Bronson","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Physiology &amp; Pediatrics University of Alberta Edmonton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Olson","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Physiology &amp; Pediatrics University of Alberta Edmonton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00624.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.00399.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.106848"},{"key":"e_1_2_7_5_1","first-page":"e101","article-title":"Term labor is associated with a core inflammatory response in human fetal membranes, myometrium, and cervix","volume":"200","author":"Bollapragada S.","year":"2009","journal-title":"Am. 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