{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:07:02Z","timestamp":1771952822990,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T00:00:00Z","timestamp":1471392000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2008-0062279"],"award-info":[{"award-number":["2008-0062279"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.14814\/phy2.12900","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T21:13:36Z","timestamp":1471468416000},"page":"e12900","source":"Crossref","is-referenced-by-count":8,"title":["Oxidative stress increases the risk of pancreatic <i>\u03b2<\/i>\n cell damage in chronic renal hypertensive rats"],"prefix":"10.14814","volume":"4","author":[{"given":"Shan","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Physiology; Chonbuk National University Medical School; Jeonju Korea"},{"name":"Department of Pharmacology; Taishan Medical University; Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung M.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physiology; Chonbuk National University Medical School; Jeonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung A.","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Physiology; Chonbuk National University Medical School; Jeonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ui J.","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Biochemistry; Research Institute for Endocrine Sciences; Chonbuk National University Medical School; Jeonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung H.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biochemistry; Research Institute for Endocrine Sciences; Chonbuk National University Medical School; Jeonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo H.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physiology; Chonbuk National University Medical School; Jeonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhn H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology; Chonbuk National University Medical School; Jeonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,17]]},"reference":[{"key":"10.14814\/phy2.12900-BIB0001|phy212900-cit-0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.regpep.2012.01.003","article-title":"Angiotensin II-induced JNK activation is mediated by NAD(P)H oxidase in isolated rat pancreatic islets","volume":"175","author":"Alves","year":"2012","journal-title":"Regul. Pept."},{"key":"10.14814\/phy2.12900-BIB0002|phy212900-cit-0002","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/oby.2009.203","article-title":"Acute effects of dietary glycemic index on antioxidant capacity in a nutrient-controlled feeding study","volume":"17","author":"Botero","year":"2009","journal-title":"Obesity"},{"key":"10.14814\/phy2.12900-BIB0003|phy212900-cit-0003","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s001250050880","article-title":"Angiotensin II and the endocrine pancreas: effects on islet blood flow and insulin secretion in rats","volume":"41","author":"Carlsson","year":"1998","journal-title":"Diabetologia"},{"key":"10.14814\/phy2.12900-BIB0004|phy212900-cit-0004","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/dmrr.634","article-title":"Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases","volume":"22","author":"Cersosimo","year":"2006","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.14814\/phy2.12900-BIB0005|phy212900-cit-0005","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1089\/ars.2011.4071","article-title":"The Renin-angiotensin system and reactive oxygen species: implications in pancreatitis","volume":"15","author":"Chan","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.14814\/phy2.12900-BIB0006|phy212900-cit-0006","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1093\/eurheartj\/ehm400","article-title":"Blood pressure and risk of developing type 2 diabetes mellitus: the Women's Health Study","volume":"28","author":"Conen","year":"2007","journal-title":"Eur. Heart J."},{"key":"10.14814\/phy2.12900-BIB0007|phy212900-cit-0007","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0140-6736(96)90013-6","article-title":"Oxidative damage to DNA in diabetes mellitus","volume":"347","author":"Dandona","year":"1996","journal-title":"Lancet"},{"key":"10.14814\/phy2.12900-BIB0008|phy212900-cit-0008","doi-asserted-by":"crossref","first-page":"406960","DOI":"10.1155\/2014\/406960","article-title":"Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension","volume":"2014","author":"Dinh","year":"2014","journal-title":"BioMed. Res. Int."},{"key":"10.14814\/phy2.12900-BIB0009|phy212900-cit-0009","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1161\/01.HYP.30.5.1156","article-title":"Angiotensin II affects basal, pulsatile, and glucose-stimulated insulin secretion in humans","volume":"30","author":"Fliser","year":"1997","journal-title":"Hypertension"},{"key":"10.14814\/phy2.12900-BIB0010|phy212900-cit-0010","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4330\/wjc.v6.i6.353","article-title":"Essential hypertension and oxidative stress: new insights","volume":"6","author":"Gonzalez","year":"2014","journal-title":"World J. Cardiol."},{"key":"10.14814\/phy2.12900-BIB0011|phy212900-cit-0011","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1530\/JOE-14-0527","article-title":"Myeloid SIRT1 regulates macrophage infiltration and insulin sensitivity in mice fed a high-fat diet","volume":"224","author":"Ka","year":"2015","journal-title":"J. Endocrinol."},{"key":"10.14814\/phy2.12900-BIB0012|phy212900-cit-0012","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0025-7125(16)30016-5","article-title":"An update on coronary risk factors","volume":"79","author":"Kannel","year":"1995","journal-title":"Med. Clin. North Am."},{"key":"10.14814\/phy2.12900-BIB0013|phy212900-cit-0013","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.biocel.2007.04.005","article-title":"Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway","volume":"39","author":"Kim","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.14814\/phy2.12900-BIB0014|phy212900-cit-0014","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/10715760802590400","article-title":"Dose-related cytoprotective effect of alpha-lipoic acid on hydrogen peroxide-induced oxidative stress to pancreatic beta cells","volume":"43","author":"Lee","year":"2009","journal-title":"Free Radic. Res."},{"key":"10.14814\/phy2.12900-BIB0015|phy212900-cit-0015","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.metabol.2007.08.020","article-title":"Glycated fetal calf serum affects the viability of an insulin-secreting cell line in\u00a0vitro","volume":"57","author":"Luciano Viviani","year":"2008","journal-title":"Metabolism"},{"key":"10.14814\/phy2.12900-BIB0016|phy212900-cit-0016","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0895-7061(02)03253-3","article-title":"Lipoic acid prevents hypertension, hyperglycemia, and the increase in heart mitochondrial superoxide production","volume":"16","author":"Midaoui","year":"2003","journal-title":"Am. J. Hypertens."},{"key":"10.14814\/phy2.12900-BIB0017|phy212900-cit-0017","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00004872-199102000-00015","article-title":"Changes in gene expression of the renin-angiotensin system in two-kidney, one clip hypertensive rats","volume":"9","author":"Morishita","year":"1991","journal-title":"J. Hypertens."},{"key":"10.14814\/phy2.12900-BIB0018|phy212900-cit-0018","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1046\/j.1440-1681.1999.03055.x","article-title":"Increased oxidative DNA damage in stroke-prone spontaneously hypertensive rats","volume":"26","author":"Negishi","year":"1999","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.14814\/phy2.12900-BIB0019|phy212900-cit-0019","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1161\/hc0402.102619","article-title":"The AT1-type angiotensin receptor in oxidative stress and atherogenesis: part II: AT1 receptor regulation","volume":"105","author":"Nickenig","year":"2002","journal-title":"Circulation"},{"key":"10.14814\/phy2.12900-BIB0020|phy212900-cit-0020","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1161\/01.CIR.98.22.2453","article-title":"Insulin induces upregulation of vascular AT1 receptor gene expression by posttranscriptional mechanisms","volume":"98","author":"Nickenig","year":"1998","journal-title":"Circulation"},{"key":"10.14814\/phy2.12900-BIB0021|phy212900-cit-0021","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1161\/01.HYP.0000040262.48405.A8","article-title":"Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling","volume":"40","author":"Ogihara","year":"2002","journal-title":"Hypertension"},{"key":"10.14814\/phy2.12900-BIB0022|phy212900-cit-0022","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbrc.2010.03.152","article-title":"Advanced glycation end-products affect transcription factors regulating insulin gene expression","volume":"395","author":"Puddu","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.14814\/phy2.12900-BIB0023|phy212900-cit-0023","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.metabol.2005.10.009","article-title":"Angiotensin II infusion decreases plasma adiponectin level via its type 1 receptor in rats: an implication for hypertension-related insulin resistance","volume":"55","author":"Ran","year":"2006","journal-title":"Metabolism"},{"key":"10.14814\/phy2.12900-BIB0024|phy212900-cit-0024","first-page":"E920","article-title":"Angiotensin II induces insulin resistance independent of changes in interstitial insulin","volume":"277","author":"Richey","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.14814\/phy2.12900-BIB0025|phy212900-cit-0025","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/hr.2010.264","article-title":"The role of oxidative stress in the pathophysiology of hypertension","volume":"34","author":"Rodrigo","year":"2011","journal-title":"Hypertens. Res."},{"key":"10.14814\/phy2.12900-BIB0026|phy212900-cit-0026","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1590\/S0100-879X2000000600006","article-title":"Oxidative stress may explain how hypertension is maintained by normal levels of angiotensin II","volume":"33","author":"Romero","year":"2000","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.14814\/phy2.12900-BIB0027|phy212900-cit-0027","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3390\/ijms16010823","article-title":"Pathogenesis of target organ damage in hypertension: role of mitochondrial oxidative stress","volume":"16","author":"Rubattu","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.14814\/phy2.12900-BIB0028|phy212900-cit-0028","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1172\/JCI119180","article-title":"Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging","volume":"99","author":"Schleicher","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.14814\/phy2.12900-BIB0029|phy212900-cit-0029","doi-asserted-by":"crossref","first-page":"H2372","DOI":"10.1152\/ajpheart.00846.2011","article-title":"Angiotensin-(1-7) attenuates hypertension in exercise-trained renal hypertensive rats","volume":"302","author":"Shah","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.14814\/phy2.12900-BIB0030|phy212900-cit-0030","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2174\/1573402111666150529130922","article-title":"Oxidative stress and antioxidants in hypertension-a current review","volume":"11","author":"Sinha","year":"2015","journal-title":"Curr. Hypertens. Rev."},{"key":"10.14814\/phy2.12900-BIB0031|phy212900-cit-0031","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1056\/NEJMe020054","article-title":"Hypertension, angiotensin II, and oxidative stress","volume":"346","author":"Sowers","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.14814\/phy2.12900-BIB0032|phy212900-cit-0032","doi-asserted-by":"crossref","first-page":"H1597","DOI":"10.1152\/ajpheart.00026.2004","article-title":"Insulin resistance and hypertension","volume":"286","author":"Sowers","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.14814\/phy2.12900-BIB0033|phy212900-cit-0033","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2337\/diabetes.53.4.989","article-title":"Improved islet morphology after blockade of the renin- angiotensin system in the ZDF rat","volume":"53","author":"Tikellis","year":"2004","journal-title":"Diabetes"},{"key":"10.14814\/phy2.12900-BIB0034|phy212900-cit-0034","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/jcb.20578","article-title":"Mitochondrial mechanism of oxidative stress and systemic hypertension in hyperhomocysteinemia","volume":"96","author":"Tyagi","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"10.14814\/phy2.12900-BIB0035|phy212900-cit-0035","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3109\/0886022X.2012.691012","article-title":"Oxidative stress in 5\/6 nephrectomized rat model: effect of alpha-lipoic acid","volume":"34","author":"Yu","year":"2012","journal-title":"Ren. Fail."},{"key":"10.14814\/phy2.12900-BIB0036|phy212900-cit-0036","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.peptides.2008.02.011","article-title":"Different response of ANP secretion to adrenoceptor stimulation in renal hypertensive rat atria","volume":"29","author":"Yuan","year":"2008","journal-title":"Peptides"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.12900","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.14814\/phy2.12900\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T13:06:17Z","timestamp":1521205577000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.14814\/phy2.12900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":36,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2016,8]]}},"URL":"https:\/\/doi.org\/10.14814\/phy2.12900","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]}}}