{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:45:35Z","timestamp":1792802735189,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T00:00:00Z","timestamp":1473033600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Career Development Award","award":["1IK2CX000547"],"award-info":[{"award-number":["1IK2CX000547"]}],"id":[{"id":"https:\/\/ror.org\/02xjhr934","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Merit Review","award":["1I01CX001040"],"award-info":[{"award-number":["1I01CX001040"]}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DMC Foundation","id":[{"id":"https:\/\/ror.org\/00yd1h406","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.14814\/phy2.12948","type":"journal-article","created":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T20:38:08Z","timestamp":1473107888000},"page":"e12948","source":"Crossref","is-referenced-by-count":23,"title":["Spinal cord injury is associated with enhanced peripheral chemoreflex sensitivity"],"prefix":"10.14814","volume":"4","author":[{"given":"Amy T.","family":"Bascom","sequence":"first","affiliation":[{"name":"John D. Dingell VA Medical Center; Detroit Michigan"},{"name":"Department of Medicine; Wayne State University; Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulghani","family":"Sankari","sequence":"additional","affiliation":[{"name":"John D. Dingell VA Medical Center; Detroit Michigan"},{"name":"Department of Medicine; Wayne State University; Detroit Michigan"},{"name":"Cardiovascular Research Institute; Wayne State University; Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Safwan","family":"Badr","sequence":"additional","affiliation":[{"name":"John D. Dingell VA Medical Center; Detroit Michigan"},{"name":"Department of Medicine; Wayne State University; Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,5]]},"reference":[{"key":"10.14814\/phy2.12948-BIB0001|phy212948-cit-0001","doi-asserted-by":"crossref","first-page":"e12490","DOI":"10.14814\/phy2.12490","article-title":"Sleep onset hypoventilation in chronic spinal cord injury","volume":"3","author":"Bascom","year":"2015","journal-title":"Physiol. Rep."},{"key":"10.14814\/phy2.12948-BIB0002|phy212948-cit-0002","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.apmr.2015.07.026","article-title":"Simplified approach to diagnosing sleep-disordered breathing and nocturnal hypercapnia in individuals with spinal cord injury","volume":"97","author":"Bauman","year":"2016","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.14814\/phy2.12948-BIB0003|phy212948-cit-0003","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.apmr.2008.12.028","article-title":"Ventilatory response to hypercapnia in C 5-8 chronic tetraplegia: the effect of posture","volume":"90","author":"Ben-Dov","year":"2009","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.14814\/phy2.12948-BIB0004|phy212948-cit-0004","volume-title":"The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications, version 2.0","author":"Berry","year":"2012"},{"key":"10.14814\/phy2.12948-BIB0005|phy212948-cit-0005","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1113\/jphysiol.2010.187211","article-title":"Peripheral chemoreceptors determine the respiratory sensitivity of central chemoreceptors to CO2","volume":"588","author":"Blain","year":"2010","journal-title":"J. Physiol."},{"key":"10.14814\/phy2.12948-BIB0007|phy212948-cit-0007","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1152\/physrev.1962.42.3.335","article-title":"Chemoreflexes in breathing","volume":"42","author":"Dejours","year":"1962","journal-title":"Physiol. Rev."},{"key":"10.14814\/phy2.12948-BIB0008|phy212948-cit-0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.2004.072371","article-title":"The ventilatory responsiveness to CO2 below eupnoea as a determinant of ventilatory stability in sleep","volume":"560","author":"Dempsey","year":"2004","journal-title":"J. Physiol."},{"key":"10.14814\/phy2.12948-BIB0009|phy212948-cit-0009","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0034-5687(67)90065-5","article-title":"Effect of the rate of rise of carotid body P co 2, on the time course of ventilation","volume":"3","author":"Dutton","year":"1967","journal-title":"Respir. Physiol."},{"key":"10.14814\/phy2.12948-BIB0010|phy212948-cit-0010","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1378\/chest.06.2287","article-title":"Central sleep apnea: pathophysiology and treatment","volume":"131","author":"Eckert","year":"2007","journal-title":"CHEST J."},{"key":"10.14814\/phy2.12948-BIB0011|phy212948-cit-0011","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0034-5687(99)00115-2","article-title":"Important role of carotid chemoreceptor afferents in control of breathing of adult and neonatal mammals","volume":"119","author":"Forster","year":"2000","journal-title":"Respir. Physiol."},{"key":"10.14814\/phy2.12948-BIB0012|phy212948-cit-0012","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1152\/jappl.1973.35.6.903","article-title":"Dynamic respiratory response to abrupt change of inspired CO2 at normal and high PO2","volume":"35","author":"Gelfand","year":"1973","journal-title":"J. Appl. Physiol."},{"key":"10.14814\/phy2.12948-BIB0013|phy212948-cit-0013","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1113\/jphysiol.2003.052894","article-title":"Neonatal maternal separation and sex-specific plasticity of the hypoxic ventilatory response in awake rat","volume":"554","author":"Genest","year":"2004","journal-title":"J. Physiol."},{"key":"10.14814\/phy2.12948-BIB0014|phy212948-cit-0014","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1001\/jama.2015.6250","article-title":"TRaumatic spinal cord injury in the united states, 1993-2012","volume":"313","author":"Jain","year":"2015","journal-title":"JAMA"},{"key":"10.14814\/phy2.12948-BIB0015|phy212948-cit-0015","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1152\/jappl.1985.59.6.1752","article-title":"Respiratory responses to ventilatory loading following low cervical spinal cord injury","volume":"59","author":"Kelling","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"10.14814\/phy2.12948-BIB0016|phy212948-cit-0016","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1152\/jappl.1982.53.3.644","article-title":"Factors inducing periodic breathing in humans: a general model","volume":"53","author":"Khoo","year":"1982","journal-title":"J. Appl. Physiol."},{"key":"10.14814\/phy2.12948-BIB0017|phy212948-cit-0017","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1164\/ajrccm.164.5.2010124","article-title":"Cardiac autonomic control in obstructive sleep apnea: effects of long-term CPAP therapy","volume":"164","author":"Khoo","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.14814\/phy2.12948-BIB0018|phy212948-cit-0018","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0034-5687(82)90026-3","article-title":"Sleep apnea considered as a control system instability","volume":"50","author":"Longobardo","year":"1982","journal-title":"Respir. Physiol."},{"key":"10.14814\/phy2.12948-BIB0019|phy212948-cit-0019","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0034-5687(92)90074-7","article-title":"Ventilatory and P 0.1 response to hypercapnia in quadriplegia","volume":"89","author":"Manning","year":"1992","journal-title":"Respir. Physiol."},{"key":"10.14814\/phy2.12948-BIB0020|phy212948-cit-0020","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1378\/chest.97.6.1446","article-title":"Respiratory complications and management of spinal cord injuries","volume":"97","author":"Mansel","year":"1990","journal-title":"Chest"},{"key":"10.14814\/phy2.12948-BIB0021|phy212948-cit-0021","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1152\/jappl.1988.64.1.84","article-title":"Single breath of CO2 as a clinical test of the peripheral chemoreflex","volume":"64","author":"McClean","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"10.14814\/phy2.12948-BIB0022|phy212948-cit-0022","doi-asserted-by":"crossref","first-page":"10073","DOI":"10.1073\/pnas.1734109100","article-title":"Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas","volume":"100","author":"Peng","year":"2003","journal-title":"Proc. Natl Acad. Sci."},{"key":"10.14814\/phy2.12948-BIB0024|phy212948-cit-0024","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1164\/rccm.200810-1658OC","article-title":"Increased propensity for central apnea in patients with obstructive sleep apnea: effect of nasal continuous positive airway pressure","volume":"181","author":"Salloum","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.14814\/phy2.12948-BIB0025|phy212948-cit-0025","first-page":"A3902","article-title":"The role of central and peripheral chemoreflex sensitivity in the pathogenesis of sleep-disordered breathing in chronic spinal cord injury","volume":"189","author":"Sankari","year":"2014a","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.14814\/phy2.12948-BIB0027|phy212948-cit-0027","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5664\/jcsm.3362","article-title":"Sleep disordered breathing in chronic spinal cord injury","volume":"10","author":"Sankari","year":"2014d","journal-title":"J. Clin. Sleep Med."},{"key":"10.14814\/phy2.12948-BIB0028|phy212948-cit-0028","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1152\/japplphysiol.00731.2013","article-title":"Tetraplegia is a risk factor for central sleep apnea","volume":"116","author":"Sankari","year":"2014c","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.14814\/phy2.12948-BIB0029|phy212948-cit-0029","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/sc.2014.216","article-title":"Identification and treatment of sleep-disordered breathing in chronic spinal cord injury","volume":"53","author":"Sankari","year":"2015","journal-title":"Spinal Cord"},{"key":"10.14814\/phy2.12948-BIB0030|phy212948-cit-0030","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1152\/japplphysiol.00088.2015","article-title":"Tetraplegia is associated with enhanced peripheral chemoreflex sensitivity and ventilatory long-term facilitation","volume":"119","author":"Sankari","year":"2015","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.14814\/phy2.12948-BIB0031|phy212948-cit-0031","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.resp.2012.09.005","article-title":"Effects of clonidine on breathing during sleep and susceptibility to central apnoea","volume":"185","author":"Sankri-Tarbichi","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.14814\/phy2.12948-BIB0032|phy212948-cit-0032","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1569-9048(03)00111-3","article-title":"Lack of gender difference in ventilatory chemoresponsiveness and post-hypoxic ventilatory decline","volume":"137","author":"Tarbichi","year":"2003","journal-title":"Respir. Physiol. Neurobiol."}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.12948","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.14814\/phy2.12948\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T15:58:36Z","timestamp":1601049516000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.14814\/phy2.12948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":29,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2016,9]]}},"URL":"https:\/\/doi.org\/10.14814\/phy2.12948","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]}}}