{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:04:55Z","timestamp":1760853895237,"version":"3.37.3"},"reference-count":51,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,9,4]],"date-time":"2016-09-04T00:00:00Z","timestamp":1472947200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL10880","HL122662","DK105160"],"award-info":[{"award-number":["HL10880","HL122662","DK105160"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["1-15-BS-172"],"award-info":[{"award-number":["1-15-BS-172"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16EIA26720006"],"award-info":[{"award-number":["16EIA26720006"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.14814\/phy2.12950","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T00:38:08Z","timestamp":1473122288000},"page":"e12950","source":"Crossref","is-referenced-by-count":8,"title":["Chronic cathepsin inhibition by E-64 in Dahl salt-sensitive rats"],"prefix":"10.14814","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4549-4281","authenticated-orcid":false,"given":"Gregory","family":"Blass","sequence":"first","affiliation":[{"name":"Department of Physiology; Medical College of Wisconsin; Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladislav","family":"Levchenko","sequence":"additional","affiliation":[{"name":"Department of Physiology; Medical College of Wisconsin; Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daria V.","family":"Ilatovskaya","sequence":"additional","affiliation":[{"name":"Department of Physiology; Medical College of Wisconsin; Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5190-8356","authenticated-orcid":false,"given":"Alexander","family":"Staruschenko","sequence":"additional","affiliation":[{"name":"Department of Physiology; Medical College of Wisconsin; Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,4]]},"reference":[{"key":"10.14814\/phy2.12950-BIB0001|phy212950-cit-0001","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1124\/mol.114.094508","article-title":"STAT3 regulates steady-state expression of synaptopodin in cultured mouse podocytes","volume":"87","author":"Abkhezr","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"10.14814\/phy2.12950-BIB0002|phy212950-cit-0002","doi-asserted-by":"crossref","first-page":"F1725","DOI":"10.1152\/ajprenal.90420.2008","article-title":"Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1","volume":"295","author":"Alcalay","year":"2008","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.14814\/phy2.12950-BIB0003|phy212950-cit-0003","doi-asserted-by":"crossref","first-page":"30073","DOI":"10.1074\/jbc.M111.338574","article-title":"Cathepsin B is secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel (ENaC) to increase its activity","volume":"287","author":"Alli","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.12950-BIB0004|phy212950-cit-0004","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.bbrc.2005.12.194","article-title":"Aldosterone-induced abnormal regulation of ENaC and SGK1 in Dahl salt-sensitive rat","volume":"341","author":"Aoi","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.14814\/phy2.12950-BIB0005|phy212950-cit-0005","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1161\/HYPERTENSIONAHA.110.157206","article-title":"Identification of cathepsin L as a potential sex-specific biomarker for renal damage","volume":"57","author":"Bauer","year":"2011","journal-title":"Hypertension"},{"key":"10.14814\/phy2.12950-BIB0006|phy212950-cit-0006","doi-asserted-by":"crossref","first-page":"6153","DOI":"10.1074\/jbc.M610636200","article-title":"Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit","volume":"282","author":"Bruns","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.12950-BIB0007|phy212950-cit-0007","doi-asserted-by":"crossref","first-page":"358","DOI":"10.2353\/ajpath.2008.071126","article-title":"Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment","volume":"173","author":"Cheng","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.14814\/phy2.12950-BIB0008|phy212950-cit-0008","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1152\/physiolgenomics.00097.2015","article-title":"Pappa2 is linked to salt-sensitive hypertension in Dahl S rats","volume":"48","author":"Cowley","year":"2016","journal-title":"Physiol. Genomics"},{"key":"10.14814\/phy2.12950-BIB0009|phy212950-cit-0009","doi-asserted-by":"crossref","first-page":"12817","DOI":"10.1073\/pnas.1410745111","article-title":"Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat","volume":"111","author":"Endres","year":"2014","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.14814\/phy2.12950-BIB0010|phy212950-cit-0010","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1165\/rcmb.2015-0090OC","article-title":"Glandular proteome identifies antiprotease cystatin C as a critical modulator of airway hydration and clearance","volume":"54","author":"Evans","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.14814\/phy2.12950-BIB0011|phy212950-cit-0011","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nm.1857","article-title":"The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A","volume":"14","author":"Faul","year":"2008","journal-title":"Nat. Med."},{"key":"10.14814\/phy2.12950-BIB0012|phy212950-cit-0012","doi-asserted-by":"crossref","first-page":"20101","DOI":"10.1038\/srep20101","article-title":"Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease","volume":"6","author":"Fox","year":"2016","journal-title":"Sci. Rep."},{"key":"10.14814\/phy2.12950-BIB0013|phy212950-cit-0013","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1097-2765(04)00209-6","article-title":"A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP\/Cux transcription factor","volume":"14","author":"Goulet","year":"2004","journal-title":"Mol. Cell"},{"key":"10.14814\/phy2.12950-BIB0014|phy212950-cit-0014","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00424-012-1138-3","article-title":"Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S","volume":"464","author":"Haerteis","year":"2012","journal-title":"Pfl\u00fcgers Arch. Eur. J. Physiol."},{"key":"10.14814\/phy2.12950-BIB0015|phy212950-cit-0015","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1093\/oxfordjournals.jbchem.a133825","article-title":"Inhibitions of cathepsin B and cathepsin L by E-64 in\u00a0vivo. II. Incorporation of [3H]E-64 into rat liver lysosomes in\u00a0vivo","volume":"91","author":"Hashida","year":"1982","journal-title":"J. Biochem."},{"key":"10.14814\/phy2.12950-BIB0016|phy212950-cit-0016","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1681\/ASN.2007030299","article-title":"Polycystic kidney disease","volume":"18","author":"Igarashi","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.12950-BIB0017|phy212950-cit-0017","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/978-1-62703-351-0_28","article-title":"Single-channel analysis of TRPC channels in the podocytes of freshly isolated glomeruli","volume":"998","author":"Ilatovskaya","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.14814\/phy2.12950-BIB0018|phy212950-cit-0018","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/ki.2014.71","article-title":"Angiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli","volume":"86","author":"Ilatovskaya","year":"2014","journal-title":"Kidney Int."},{"key":"10.14814\/phy2.12950-BIB0019|phy212950-cit-0019","doi-asserted-by":"crossref","first-page":"17637","DOI":"10.1038\/srep17637","article-title":"Podocyte injury in diabetic nephropathy: implications of angiotensin II-dependent activation of TRPC channels","volume":"5","author":"Ilatovskaya","year":"2015a","journal-title":"Sci. Rep."},{"key":"10.14814\/phy2.12950-BIB0020|phy212950-cit-0020","first-page":"e52850","article-title":"Single-channel analysis and calcium imaging in the podocytes of the freshly isolated glomeruli","volume":"100","author":"Ilatovskaya","year":"2015b","journal-title":"J. Vis. Exp."},{"key":"10.14814\/phy2.12950-BIB0021|phy212950-cit-0021","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1074\/jbc.272.2.1197","article-title":"Role of the occluding loop in cathepsin B activity","volume":"272","author":"Illy","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.12950-BIB0022|phy212950-cit-0022","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1083\/jcb.200208154","article-title":"Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells","volume":"159","author":"Jaiswal","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.14814\/phy2.12950-BIB0023|phy212950-cit-0023","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1097\/HJH.0b013e32832c7d23","article-title":"Aberrant ENaC activation in Dahl salt-sensitive rats","volume":"27","author":"Kakizoe","year":"2009","journal-title":"J. Hypertens."},{"key":"10.14814\/phy2.12950-BIB0024|phy212950-cit-0024","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/HYPERTENSIONAHA.110.157784","article-title":"Novel role of Rac1\/WAVE signaling mechanism in regulation of the epithelial Na+ channel","volume":"57","author":"Karpushev","year":"2011","journal-title":"Hypertension"},{"key":"10.14814\/phy2.12950-BIB0025|phy212950-cit-0025","doi-asserted-by":"crossref","first-page":"375345","DOI":"10.1155\/2010\/375345","article-title":"Posttranslational processing and modification of cathepsins and cystatins","volume":"2010","author":"Katunuma","year":"2010","journal-title":"J. Signal Transduct."},{"key":"10.14814\/phy2.12950-BIB0026|phy212950-cit-0026","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s00467-009-1425-1","article-title":"Enzymatic disease of the podocyte","volume":"25","author":"Kistler","year":"2010","journal-title":"Pediatr. Nephrol."},{"key":"10.14814\/phy2.12950-BIB0027|phy212950-cit-0027","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/oxfordjournals.jbchem.a135277","article-title":"Distribution of cathepsins B and H in rat tissues and peripheral blood cells","volume":"98","author":"Kominami","year":"1985","journal-title":"J. Biochem."},{"key":"10.14814\/phy2.12950-BIB0028|phy212950-cit-0028","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0006-291X(87)80028-1","article-title":"Autodegradation of lysosomal cysteine proteinases","volume":"144","author":"Kominami","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.14814\/phy2.12950-BIB0029|phy212950-cit-0029","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/jb\/mvj037","article-title":"Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B","volume":"139","author":"Laurent-Matha","year":"2006","journal-title":"J. Biochem."},{"key":"10.14814\/phy2.12950-BIB0030|phy212950-cit-0030","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1681\/ASN.2011060595","article-title":"TORCing up the importance of calcium signaling","volume":"22","author":"Lavin","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.12950-BIB0031|phy212950-cit-0031","doi-asserted-by":"crossref","first-page":"H1530","DOI":"10.1152\/ajpheart.01026.2010","article-title":"Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strains","volume":"300","author":"Moreno","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.14814\/phy2.12950-BIB0032|phy212950-cit-0032","doi-asserted-by":"crossref","first-page":"41012","DOI":"10.1074\/jbc.M405333200","article-title":"Exon skipping of cathepsin B: mitochondrial targeting of a lysosomal peptidase provokes cell death","volume":"279","author":"Muntener","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.12950-BIB0033|phy212950-cit-0033","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1002\/j.1460-2075.1991.tb07771.x","article-title":"The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity","volume":"10","author":"Musil","year":"1991","journal-title":"EMBO J."},{"key":"10.14814\/phy2.12950-BIB0034|phy212950-cit-0034","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1161\/01.HYP.0000222003.28517.99","article-title":"Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker","volume":"47","author":"Nagase","year":"2006","journal-title":"Hypertension"},{"key":"10.14814\/phy2.12950-BIB0035|phy212950-cit-0035","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/physrev.00020.2002","article-title":"Cell biology of the glomerular podocyte","volume":"83","author":"Pavenstadt","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.14814\/phy2.12950-BIB0036|phy212950-cit-0036","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1681\/ASN.2012080839","article-title":"Deficiency of renal cortical EGF increases ENaC activity and contributes to salt-sensitive hypertension","volume":"24","author":"Pavlov","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.12950-BIB0037|phy212950-cit-0037","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1152\/physiolgenomics.00214.2005","article-title":"High-throughput identification of IMCD proteins using LC-MS\/MS","volume":"25","author":"Pisitkun","year":"2006","journal-title":"Physiol. Genomics"},{"key":"10.14814\/phy2.12950-BIB0038|phy212950-cit-0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1681\/ASN.2014060618","article-title":"Cutting it out: ENaC processing in the human nephron","volume":"26","author":"Ray","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.12950-BIB0039|phy212950-cit-0039","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0092-8674(01)00421-4","article-title":"Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes","volume":"106","author":"Reddy","year":"2001","journal-title":"Cell"},{"key":"10.14814\/phy2.12950-BIB0040|phy212950-cit-0040","doi-asserted-by":"crossref","first-page":"34827","DOI":"10.1074\/jbc.M401973200","article-title":"Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin","volume":"279","author":"Reiser","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.12950-BIB0041|phy212950-cit-0041","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1515\/BC.2004.040","article-title":"Comprehensive search for cysteine cathepsins in the human genome","volume":"385","author":"Rossi","year":"2004","journal-title":"Biol. Chem."},{"key":"10.14814\/phy2.12950-BIB0042|phy212950-cit-0042","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1172\/JCI32022","article-title":"Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease","volume":"117","author":"Sever","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.14814\/phy2.12950-BIB0043|phy212950-cit-0043","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.apsb.2015.08.001","article-title":"Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors","volume":"5","author":"Siklos","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.14814\/phy2.12950-BIB0044|phy212950-cit-0044","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/cphy.c110052","article-title":"Regulation of transport in the connecting tubule and cortical collecting duct","volume":"2","author":"Staruschenko","year":"2012","journal-title":"Compr. Physiol."},{"key":"10.14814\/phy2.12950-BIB0045|phy212950-cit-0045","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1681\/ASN.2008040364","article-title":"Plasmin in nephrotic urine activates the epithelial sodium channel","volume":"20","author":"Svenningsen","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.12950-BIB0046|phy212950-cit-0046","doi-asserted-by":"crossref","first-page":"5251","DOI":"10.1113\/jphysiol.2013.267286","article-title":"Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures","volume":"592","author":"Tan","year":"2014","journal-title":"J. Physiol."},{"key":"10.14814\/phy2.12950-BIB0047|phy212950-cit-0047","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbapap.2011.10.002","article-title":"Cysteine cathepsins: from structure, function and regulation to new frontiers","volume":"1824","author":"Turk","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.14814\/phy2.12950-BIB0048|phy212950-cit-0048","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1515\/BC.2004.082","article-title":"Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells","volume":"385","author":"Wille","year":"2004","journal-title":"Biol. Chem."},{"key":"10.14814\/phy2.12950-BIB0049|phy212950-cit-0049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1681\/ASN.2015040366","article-title":"Cathepsin D in podocytes is important in the pathogenesis of proteinuria and CKD","volume":"27","author":"Yamamoto-Nonaka","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.12950-BIB0050|phy212950-cit-0050","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1681\/ASN.2013111173","article-title":"The epithelial sodium channel \u03b3-subunit is processed proteolytically in human kidney","volume":"26","author":"Zachar","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.12950-BIB0051|phy212950-cit-0051","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1016\/j.bbamcr.2008.07.027","article-title":"Role of the proteolytic hierarchy between cathepsin L, cathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy","volume":"1783","author":"Zheng","year":"2008","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.12950","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.14814\/phy2.12950\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T20:02:31Z","timestamp":1657224151000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.14814\/phy2.12950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":51,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2016,9]]}},"URL":"https:\/\/doi.org\/10.14814\/phy2.12950","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"type":"print","value":"2051-817X"}],"subject":[],"published":{"date-parts":[[2016,9]]}}}